Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal (Q37034948)

17 August 2017

Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal (English)

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17 August 2017

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mesenchymal stem cell

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Buer Sen

1

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17 August 2017

Zhihui Xie

2

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17 August 2017

Natasha Case

3

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17 August 2017

Meiyun Ma

4

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17 August 2017

Clinton Rubin

5

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17 August 2017

Janet Rubin

6

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17 August 2017

language of work or name

English

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publication date

7 August 2008

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17 August 2017

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17 August 2017

149

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17 August 2017

12

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17 August 2017

6065-6075

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describes a project that uses

17 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2613068/fullTextXML

inferred from PubMed Central ID database lookup

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Transient down-regulation of cbfa1/Runx2 by RNA interference in murine C3H10T1/2 mesenchymal stromal cells delays in vitro and in vivo osteogenesis, but does not overtly affect chondrogenesis.

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Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals

29 September 2017

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Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells

29 September 2017

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29 September 2017

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Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis

29 September 2017

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Response to mechanical strain in an immortalized pre-osteoblast cell is dependent on ERK1/2.

29 September 2017

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29 September 2017

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29 September 2017

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Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation

29 September 2017

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PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors

29 September 2017

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29 September 2017

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Multilineage potential of adult human mesenchymal stem cells

29 September 2017

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Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

29 September 2017

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29 September 2017

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29 September 2017

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Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures

29 September 2017

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Simulation of cell differentiation in fracture healing: mechanically loaded composite scaffolds in a novel bioreactor system.

27 June 2018

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Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shear

4 September 2018

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Stretch-induced PTH-related protein gene expression in osteoblasts

4 September 2018

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Akt mediates mechanical strain-induced collagen production by mesangial cells

4 September 2018

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Modeled microgravity inhibits osteogenic differentiation of human mesenchymal stem cells and increases adipogenesis

4 September 2018

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Wnt signaling controls the phosphorylation status of beta-catenin.

4 September 2018

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Activation of the Wnt signaling pathway: a molecular mechanism for lithium action

4 September 2018

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Interconversion potential of cloned human marrow adipocytes in vitro

4 September 2018

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12 December 2020

The pathway of bone fluid flow as defined by in vivo intramedullary pressure and streaming potential measurements

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12 December 2020

Activation of extracellular signal-regulated kinase is involved in mechanical strain inhibition of RANKL expression in bone stromal cells

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12 December 2020

Marrow changes in paraplegic patients

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12 December 2020

Strain gradients correlate with sites of exercise-induced bone-forming surfaces in the adult skeleton

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12 December 2020

Strain amplification in the bone mechanosensory system

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12 December 2020

Increased muscle mass with myostatin deficiency improves gains in bone strength with exercise

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12 December 2020

Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells

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12 December 2020

Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone

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12 December 2020

Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma

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12 December 2020

Angiogenesis is induced by airway smooth muscle strain

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12 December 2020

Identifiers

DOI

10.1210/EN.2008-0687

1 reference

17 August 2017

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17 August 2017

PubMed publication ID

18687779

1 reference