Alkyltransferase-mediated toxicity of 1,3-butadiene diepoxide (Q37037487)

17 August 2017

Alkyltransferase-mediated toxicity of 1,3-butadiene diepoxide (English)

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17 August 2017

Aley G Kalapila

1

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17 August 2017

Natalia A Loktionova

series ordinal

2

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17 August 2017

Anthony E Pegg

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3

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17 August 2017

20 August 2008

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Chemical Research in Toxicology

17 August 2017

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17 August 2017

21

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17 August 2017

9

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17 August 2017

1851-1861

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describes a project that uses

17 August 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2614079/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Cross-linking of the DNA repair protein Omicron6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards.

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Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations

29 September 2017

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DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy

29 September 2017

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Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane

29 September 2017

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Repair of DNA-polypeptide crosslinks by human excision nuclease

29 September 2017

1 reference

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Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase

29 September 2017

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Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophiles by conjugation

29 September 2017

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O6-alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromomethane and bromomethyl acetate.

29 September 2017

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Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.

29 September 2017

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Variability and regulation of O6-alkylguanine-DNA alkyltransferase

29 September 2017

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Use of the rpoB gene to determine the specificity of base substitution mutations on the Escherichia coli chromosome

29 September 2017

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DNA-binding mechanism of O6-alkylguanine-DNA alkyltransferase. Effects of protein and DNA alkylation on complex stability

29 September 2017

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Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase

29 September 2017

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O6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy

29 September 2017

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A review of the genetic and related effects of 1,3-butadiene in rodents and humans

29 September 2017

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Repair of O(6)-alkylguanine by alkyltransferases

29 September 2017

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Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding

29 September 2017

1 reference

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Mammalian cells expressing Escherichia coli O6-alkylguanine-DNA alkyltransferases are hypersensitive to dibromoalkanes.

29 September 2017

1 reference

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Isolation of human O6-alkylguanine-DNA alkyltransferase mutants highly resistant to inactivation by O6-benzylguanine

29 September 2017

1 reference

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Adenine adducts with diepoxybutane: isolation and analysis in exposed calf thymus DNA.

29 September 2017

1 reference

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Structure, Function, and Inhibition of O6-Alkylguanine-DNA Alkyltransferase

29 September 2017

1 reference

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1,3-Butadiene working group report.

29 September 2017

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Mutational specificity of depurination

29 September 2017

1 reference

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Site specific N6-(2-hydroxy-3,4-epoxybut-1-yl)adenine oligodeoxynucleotide adducts of 1,2,3,4-diepoxybutane: synthesis and stability at physiological pH.

29 September 2017

1 reference

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Overexpression of antizyme in the hearts of transgenic mice prevents the isoprenaline-induced increase in cardiac ornithine decarboxylase activity and polyamines, but does not prevent cardiac hypertrophy.

27 June 2018

1 reference

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Bacterial and mammalian DNA alkyltransferases sensitize Escherichia coli to the lethal and mutagenic effects of dibromoalkanes.

27 June 2018

1 reference

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Synthesis, Characterization, and in Vitro Quantitation of N-7-Guanine Adducts of Diepoxybutane

27 June 2018

1 reference

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Resistance of the human O6-alkylguanine-DNA alkyltransferase containing arginine at codon 160 to inactivation by O6-benzylguanine.

27 June 2018

1 reference

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Targeted A --> T and G --> T mutations induced by site-specific deoxyadenosine and deoxyguanosine adducts, respectively, from the (+)-anti-diol epoxide of dibenz[a,j]anthracene in M13mp7L2.

27 June 2018

1 reference

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Mutagenicity of butadiene and its epoxide metabolites: II. Mutational spectra of butadiene, 1,2-epoxybutene and diepoxybutane at the hprt locus in splenic T cells from exposed B6C3F1 mice.

27 June 2018

1 reference

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Mutagenicity of 1,3-butadiene and its epoxide metabolites in human TK6 cells and in splenic T cells isolated from exposed B6C3F1 mice

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2614079

Carcnogenicity of epoxides, lactones, and peroxy compounds. VI. Structure and carcinogenic activity

27 June 2018

1 reference

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Function of domains of human O6-alkylguanine-DNA alkyltransferase

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2614079

Initiation of repair of DNA-polypeptide cross-links by the UvrABC nuclease

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2614079

Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2614079

DNA binding and nucleotide flipping by the human DNA repair protein AGT.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2614079

Structural characterization of the major DNA-DNA cross-link of 1,2,3,4-diepoxybutane

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2614079

O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2614079

Mutations induced by 1,3-butadiene metabolites, butadiene diolepoxide, and 1,2,3,4-diepoxybutane at the Hprt locus in CHO-K1 cells

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2614079

Inactivation and degradation of O(6)-alkylguanine-DNA alkyltransferase after reaction with nitric oxide

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2614079

Synthesis and characterization of nucleosides and oligonucleotides bearing adducts of butadiene epoxides on adenine n(6) and guanine n(2).

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2614079

The role of human O(6)-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in Escherichia coli

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2614079

Expression of the inactive C145A mutant human O6-alkylguanine-DNA alkyltransferase in E.coli increases cell killing and mutations by N-methyl-N'-nitro-N-nitrosoguanidine.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2614079

Mammalian DNA repair methyltransferases shield O4MeT from nucleotide excision repair.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2614079

Amino acid residues affecting the activity and stability of human O6-alkylguanine-DNA alkyltransferase.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2614079

Mutagenicity of the racemic mixtures of butadiene monoepoxide and butadiene diepoxide at the Hprt locus of T-lymphocytes following inhalation exposures of female mice and rats

4 September 2018

1 reference

12 December 2020

Structural elucidation of a novel DNA-DNA cross-link of 1,2,3,4-diepoxybutane

1 reference

12 December 2020

Comparison of the mutations at Hprt exon 3 of T-lymphocytes from B6C3F1 mice and F344 rats exposed by inhalation to 1,3-butadiene or the racemic mixture of 1,2:3,4-diepoxybutane

1 reference

12 December 2020

Mutagenic potential of adenine N(6) adducts of monoepoxide and diolepoxide derivatives of butadiene

1 reference

12 December 2020

Insertion of nucleotides opposite apurinic/apyrimidinic sites in deoxyribonucleic acid during in vitro synthesis: uniqueness of adenine nucleotides

1 reference

12 December 2020

Expression and secretion of foreign proteins in Escherichia coli

1 reference

12 December 2020

Mutagenicity of butadiene and its epoxide metabolites: I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts

1 reference

12 December 2020

Alteration of arginine-128 to alanine abolishes the ability of human O6-alkylguanine-DNA alkyltransferase to repair methylated DNA but has no effect on its reaction with O6-benzylguanine

1 reference

12 December 2020

ogt alkyltransferase enhances dibromoalkane mutagenicity in excision repair–deficientescherichia coli K-12

1 reference

12 December 2020

Identifiers

DOI

10.1021/TX800178T

1 reference

17 August 2017

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17 August 2017

PubMed publication ID

18712882

1 reference