Pathway analysis tools and toxicogenomics reference databases for risk assessment (Q37043499)

17 August 2017

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title

Pathway analysis tools and toxicogenomics reference databases for risk assessment (English)

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17 August 2017

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Brigitte Ganter

1

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17 August 2017

Nadine Zidek

2

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17 August 2017

Philip R Hewitt

3

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17 August 2017

Dieter Müller

4

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17 August 2017

Antoaneta Vladimirova

5

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17 August 2017

1 January 2008

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17 August 2017

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17 August 2017

9

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17 August 2017

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17 August 2017

35-54

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Toxicogenomics and systems toxicology: aims and prospects

17 August 2017

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Toxicoproteomics: proteomics applied to toxicology and pathology

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Microarrays and toxicology: the advent of toxicogenomics

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Clofibrate-induced gene expression changes in rat liver: a cross-laboratory analysis using membrane cDNA arrays

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Functional discovery via a compendium of expression profiles

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Toxicogenomics in drug discovery and development: mechanistic analysis of compound/class-dependent effects using the DrugMatrix database

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Support vector machine classification and validation of cancer tissue samples using microarray expression data

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Classification of a large microarray data set: algorithm comparison and analysis of drug signatures

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Can the pharmaceutical industry reduce attrition rates?

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Gene expression profiling of rat livers reveals indicators of potential adverse effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

The need to decide if all estrogens are intrinsically similar

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Mechanistic toxicogenomic analysis of WAY-144122 administration in Sprague-Dawley rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

A gene expression signature that predicts the future onset of drug-induced renal tubular toxicity

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Assessment of hepatotoxic liabilities by transcript profiling

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Toxicogenomics: a new revolution in drug safety

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

NSAID-induced acute phase response is due to increased intestinal permeability and characterized by early and consistent alterations in hepatic gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Oncogenic pathway signatures in human cancers as a guide to targeted therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Evaluation of DNA microarray results with quantitative gene expression platforms

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Rat toxicogenomic study reveals analytical consistency across microarray platforms

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Differential display in rat livers treated for 13 weeks with phenobarbital implicates a role for metabolic and oxidative stress in nongenotoxic carcinogenicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Microarray analysis in human hepatocytes suggests a mechanism for hepatotoxicity induced by trovafloxacin.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

21 January 2018

The digital code of DNA.

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Systems biology, metabolic modelling and metabolomics in drug discovery and development

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Pathway analysis for design of promiscuous drugs and selective drug mixtures

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

MINT: a Molecular INTeraction database

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

HomoMINT: an inferred human network based on orthology mapping of protein interactions discovered in model organisms

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Functional organization of the yeast proteome by systematic analysis of protein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

The protein-protein interaction map of Helicobacter pylori

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

A protein interaction map of Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

A map of the interactome network of the metazoan C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

On the Interpretation of χ 2 from Contingency Tables, and the Calculation of P

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Systematic determination of genetic network architecture

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

STRING 7--recent developments in the integration and prediction of protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

From biological databases to platforms for biomedical discovery.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Development of human protein reference database as an initial platform for approaching systems biology in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

VisANT 3.0: new modules for pathway visualization, editing, prediction and construction

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

MedScan, a natural language processing engine for MEDLINE abstracts.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Systems biology markup language: Level 2 and beyond

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Next generation simulation tools: the Systems Biology Workbench and BioSPICE integration

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

CEBS object model for systems biology data, SysBio-OM.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Development of public toxicogenomics software for microarray data management and analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

ArrayExpress--a public repository for microarray gene expression data at the EBI

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Annotation transfer between genomes: protein-protein interologs and protein-DNA regulogs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Precision-cut tissue slices: applications in pharmacology and toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Morphology and cytochrome P450 isoforms expression in precision-cut rat liver slices

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Initial responses to endotoxins and Gram-negative bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Modeling cellular machinery through biological network comparison

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Towards zoomable multidimensional maps of the cell

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Identification of in vitro protein biomarkers of idiosyncratic liver toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Applications of microarrays with toxicologically relevant genes (tox genes) for the evaluation of chemical toxicants in Sprague Dawley rats in vivo and human hepatocytes in vitro

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.1.35

Human and animal hepatocytes in vitro with extrapolation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.1.35

21 January 2018

Identifiers

DOI

10.2217/14622416.9.1.35

1 reference

17 August 2017

1 reference