The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines (Q37049023)

17 August 2017

1 reference

title

The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines (English)

1 reference

17 August 2017

0 references

1 reference

Robin L Thurmond

1

0 references

Erwin W. Gelfand

series ordinal

2

object named as

Erwin W Gelfand

1 reference

17 August 2017

Paul J Dunford

3

1 reference

17 August 2017

1 January 2008

1 reference

Nature Reviews Drug Discovery

17 August 2017

1 reference

17 August 2017

7

1 reference

17 August 2017

1

1 reference

17 August 2017

41-53

1 reference

https://scigraph.springernature.com/pub.10.1038/nrd2465

17 August 2017

0 references

cites work

Developments in the inhibition of gastric acid secretion

1 reference

The role of histamine and the tuberomamillary nucleus in the nervous system

31 March 2020

1 reference

Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway

31 March 2020

1 reference

Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with methacholine bronchial hyperresponsiveness

31 March 2020

1 reference

Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with increased airway obstruction

31 March 2020

1 reference

Evidence for elevated levels of histamine, prostaglandin D2, and other bronchoconstricting prostaglandins in the airways of subjects with mild asthma

31 March 2020

1 reference

Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity.

31 March 2020

1 reference

Activation of pulmonary mast cells by bronchoalveolar allergen challenge. In vivo release of histamine and tryptase in atopic subjects with and without asthma

31 March 2020

1 reference

Skin histamine levels in chronic atopic dermatitis

31 March 2020

1 reference

Assessment of tissue fluid histamine levels in patients with urticaria

31 March 2020

1 reference

Histamine and histamine-N-methyltransferase in the CSF of patients with multiple sclerosis

31 March 2020

1 reference

Studies on mast cells and histamine release in psoriasis: the effect of ranitidine.

31 March 2020

1 reference

Studies of histamine in the rheumatoid joint

31 March 2020

1 reference

cDNA cloning and characterization of porcine histamine H4 receptor

31 March 2020

1 reference

Molecular cloning of monkey histamine H4 receptor

31 March 2020

1 reference

The histamine H3 receptor: from gene cloning to H3 receptor drugs

31 March 2020

1 reference

Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells

31 March 2020

1 reference

Receptors mediating some actions of histamine

31 March 2020

1 reference

Definition and antagonism of histamine H 2 -receptors

31 March 2020

1 reference

Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor

31 March 2020

1 reference

Cloning and functional expression of the human histamine H3 receptor

31 March 2020

1 reference

Histamine H3 receptor ligands break ground in a remarkable plethora of therapeutic areas

31 March 2020

1 reference

Central histamine H3 receptor signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS.

31 March 2020

1 reference

Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes

31 March 2020

1 reference

Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow

31 March 2020

2 references

31 March 2020

inferred from DOI database lookup

7 January 2021

based on heuristic

The selective eosinophil chemotactic activity of histamine

1 reference

Pharmacologic characterization of a novel histamine receptor on human eosinophils

31 March 2020

1 reference

Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist

31 March 2020

1 reference

Discovery of a novel member of the histamine receptor family

31 March 2020

1 reference

Genomics meets histamine receptors: new subtypes, new receptors.

31 March 2020

1 reference

Liver-expressed chemokine/CC chemokine ligand 16 attracts eosinophils by interacting with histamine H4 receptor

31 March 2020

1 reference

A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties

31 March 2020

1 reference

Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat.

31 March 2020

1 reference

The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells.

31 March 2020

1 reference

Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus

31 March 2020

1 reference

Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation

31 March 2020

1 reference

Critical Role of Histamine H4Receptor in Leukotriene B4Production and Mast Cell-Dependent Neutrophil Recruitment Induced by Zymosan in Vivo

31 March 2020

1 reference

Differentiation of monocytes into macrophages induces the upregulation of histamine H1 receptor

31 March 2020

1 reference

Histamine downregulates monocyte CCL2 production through the histamine H4 receptor

31 March 2020

1 reference

Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells

31 March 2020

1 reference

Human skin mast cells express H2 and H4, but not H3 receptors

31 March 2020

1 reference

H4 histamine receptor mediates optimal migration of mast cell precursors to CXCL12

31 March 2020

1 reference

Dynamics of mast cells in the nasal mucosa of patients with allergic rhinitis and non-allergic controls: a biopsy study

31 March 2020

1 reference

Increase in epithelial mast cell numbers in the nasal mucosa of patients with perennial allergic rhinitis

31 March 2020

1 reference

Severity of ulcerative colitis is associated with a polymorphism at diamine oxidase gene but not at histamine N-methyltransferase gene

31 March 2020

1 reference

Inhibition of cytokine secretion from human leukemic mast cells and basophils by H1- and H2-receptor antagonists

31 March 2020

1 reference

Histamine inhibits tumor necrosis factor alpha release by mast cells through H2 and H3 receptors

31 March 2020

1 reference

Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation

31 March 2020

1 reference

Histamine induces cytoskeletal changes in human eosinophils via the H4 receptor

31 March 2020

1 reference

In vitro effects of histamine on eosinophil migration

31 March 2020

1 reference

Superoxide Production by Eosinophils: Activation by Histamine

31 March 2020

1 reference

Expression and function of histamine receptors in human monocyte-derived dendritic cells

31 March 2020

1 reference

Expression and function of histamine receptors 1 and 2 on human monocyte-derived dendritic cells

31 March 2020

1 reference

Cutting edge: histamine inhibits IFN-alpha release from plasmacytoid dendritic cells

31 March 2020

1 reference

Histamine induces CD86 expression and chemokine production by human immature dendritic cells

31 March 2020

1 reference

The mast cell mediator PGD2 suppresses IL-12 release by dendritic cells leading to Th2 polarized immune responses in vivo

31 March 2020

1 reference

Histamine polarizes human dendritic cells into Th2 cell-promoting effector dendritic cells

31 March 2020

1 reference

Histamine and prostaglandin E up-regulate the production of Th2-attracting chemokines (CCL17 and CCL22) and down-regulate IFN-gamma-induced CXCL10 production by immature human dendritic cells.

31 March 2020

1 reference

Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors

31 March 2020

1 reference

The H1 histamine receptor regulates allergic lung responses.

31 March 2020

1 reference

Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model.

31 March 2020

1 reference

Augmentation of antigen receptor-mediated responses by histamine H1 receptor signaling

31 March 2020

1 reference

H1 histamine receptor antagonist inhibits constitutive growth of Jurkat T cells and antigen-specific proliferation of ovalbumin-specific murine T cells

31 March 2020

1 reference

Histamine: its novel role as an endogenous regulator of Con A-dependent T cell proliferation

31 March 2020

1 reference

Histamine blocks interleukin 2 (IL-2) gene expression and regulates IL-2 receptor expression

31 March 2020

1 reference

Histamine enhances TGF-beta1-mediated suppression of Th2 responses.

31 March 2020

1 reference

Inhibitory effects of histamine on interleukin 2 and gamma interferon production of different human T helper cell subsets

31 March 2020

1 reference

Histamine acts directly on human T cells to inhibit interleukin-2 and interferon-gamma production

31 March 2020

1 reference

Histamine inhibits interferon-gamma production via suppression of interleukin 2 synthesis

31 March 2020

1 reference

Different modulation by histamine of IL-4 and interferon-gamma (IFN-gamma) release according to the phenotype of human Th0, Th1 and Th2 clones

31 March 2020

1 reference

Regulation of interleukin-10 secretion by histamine in TH2 cells and splenocytes

31 March 2020

1 reference

Regulation of IL-4 and IL-5 secretion by histamine and PGE2

31 March 2020

1 reference

Histamine modulates the production of interferon-gamma and interleukin-2 by mitogen-activated human mononuclear blood cells

31 March 2020

1 reference

Histamine affects interleukin-4, interleukin-5, and interferon-gamma production by human T cell clones from the airways and blood

31 March 2020

1 reference

Involvement of protein kinase A in histamine-mediated inhibition of IL-2 mRNA expression in mouse splenocytes

31 March 2020

1 reference

Histamine increases anti-CD3 induced IL-5 production of TH2-type T cells via histamine H2-receptors

31 March 2020

1 reference

Regulation of Con A-dependent cytokine production from CD4+ and CD8+ T lymphocytes by autosecretion of histamine

31 March 2020

1 reference

Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells

31 March 2020

1 reference

Histamine inhibits the production of interleukin-12 through interaction with H2 receptors

31 March 2020

1 reference

Histamine inhibits interleukin 1 production by lipopolysaccharide-stimulated human peripheral blood monocytes

31 March 2020

1 reference

Effect of histamine on tumor necrosis factor production by human monocytes.

31 March 2020

1 reference

Histamine downregulates CD14 expression via H2 receptors on human monocytes

31 March 2020

1 reference

Histamine inhibits lipopolysaccharide-induced interleukin (IL)-18 production in human monocytes

31 March 2020

1 reference

Histamine-induced activation of human lung macrophages

31 March 2020

1 reference

Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors.

31 March 2020

1 reference

Histamine type I receptor occupancy increases endothelial cytosolic calcium, reduces F-actin, and promotes albumin diffusion across cultured endothelial monolayers

31 March 2020

1 reference

Histamine alters E-cadherin cell adhesion to increase human airway epithelial permeability.

31 March 2020

1 reference

Histamine alters gene expression in cultured human nasal epithelial cells

31 March 2020

1 reference

Inhibitory activity of loratadine and descarboxyethoxyloratadine on histamine-induced activation of endothelial cells

31 March 2020

1 reference

Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a juxtacrine system for adhesion and activation of neutrophils

31 March 2020

1 reference

Interleukin 4 or oncostatin M induces a prolonged increase in P-selectin mRNA and protein in human endothelial cells

31 March 2020

1 reference

Rapid neutrophil adhesion to activated endothelium mediated by GMP-140.

31 March 2020

1 reference

P-selectin mediates neutrophil rolling on histamine-stimulated endothelial cells

31 March 2020

1 reference

Histamine induces IL-6 production by human endothelial cells

31 March 2020

1 reference

Rapid secretion of prestored interleukin 8 from Weibel-Palade bodies of microvascular endothelial cells

31 March 2020

1 reference

Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate

31 March 2020

1 reference

Histamine induces Toll-like receptor 2 and 4 expression in endothelial cells and enhances sensitivity to Gram-positive and Gram-negative bacterial cell wall components

31 March 2020

1 reference

Histamine Activates Bronchial Epithelial Cells to Release Inflammatory Cytokines in vitro

31 March 2020

1 reference

The response of a human bronchial epithelial cell line to histamine: intracellular calcium changes and extracellular release of inflammatory mediators

31 March 2020

1 reference

Inhibition of cell differentiation by G alpha q in the renal epithelial cell line LLC-PK1.

31 March 2020

1 reference

Histamine H1 receptor-stimulated interleukin 8 and granulocyte macrophage colony-stimulating factor production by bronchial epithelial cells requires extracellular signal-regulated kinase signaling via protein kinase C.

31 March 2020

1 reference

Inhibitory activity of loratadine and descarboethoxyloratadine on expression of ICAM-1 and HLA-DR by nasal epithelial cells

31 March 2020

1 reference

The global burden of asthma

31 March 2020

1 reference

31 March 2020

1 reference

31 March 2020

Asthma and inflammation

1 reference

Immunological aspects of allergic asthma

31 March 2020

1 reference

Asthma. From bronchoconstriction to airways inflammation and remodeling

31 March 2020

1 reference

Airway remodeling contributes to the progressive loss of lung function in asthma: an overview

31 March 2020

1 reference

Current therapies for asthma. Promise and limitations

31 March 2020

1 reference

Pharmacological management of mild or moderate persistent asthma

31 March 2020

1 reference

Bronchodilating activity of an H blocker, chlorpheniramine

31 March 2020

1 reference

Effect of an H1 blocker, chlorpheniramine, on inhalation tests with histamine and allergen in allergic asthma

31 March 2020

1 reference

Effects of oral H1 and H2 receptor antagonists in asthma

31 March 2020

1 reference

Effects of antihistamines in adult asthma: a meta-analysis of clinical trials

31 March 2020

1 reference

The inhibitory effect of terfenadine and flurbiprofen on early and late-phase bronchoconstriction following allergen challenge in atopic asthma

31 March 2020

1 reference

Treatment of bronchial asthma with terfenadine; a randomized controlled trial

31 March 2020

1 reference

Efficacy and safety of loratadine plus pseudoephedrine in patients with seasonal allergic rhinitis and mild asthma

31 March 2020

1 reference

Montelukast, a leukotriene receptor antagonist, in combination with loratadine, a histamine receptor antagonist, in the treatment of chronic asthma

31 March 2020

1 reference

The relationship between plasma histamine concentrations and bronchial obstruction to antigen challenge in allergic rhinitis

31 March 2020

1 reference

Histamine H2 receptor-mediated airway goblet cell secretion and its modulation by histamine-degrading enzymes.

31 March 2020

1 reference

Capsaicin and histamine antagonist-sensitive mechanisms in the immediate allergic reaction of pig airways.

31 March 2020

1 reference

H2-receptor blockade and exercise-induced asthma

31 March 2020

1 reference

Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma

31 March 2020

1 reference

Oral administration of desloratadine prior to sensitization prevents allergen-induced airway inflammation and hyper-reactivity in mice

31 March 2020

1 reference

Histamine type 1 receptor deficiency reduces airway inflammation in a murine asthma model

31 March 2020

1 reference

Fexofenadine modulates T-cell function, preventing allergen-induced airway inflammation and hyperresponsiveness

31 March 2020

1 reference

Effects of fexofenadine on T-cell function in a murine model of allergen-induced airway inflammation and hyperresponsiveness

31 March 2020

1 reference

Neutrophil histamine contributes to inflammation in mycoplasma pneumonia

31 March 2020

1 reference

Skin histamine in chronic urticaria

31 March 2020

1 reference

Specific C-receptors for itch in human skin.

31 March 2020

1 reference

Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch

31 March 2020

1 reference

Phospholipase Cbeta 3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons

31 March 2020

1 reference

Characterisation of the calcium responses to histamine in capsaicin-sensitive and capsaicin-insensitive sensory neurones.

31 March 2020

1 reference

Immunohistochemical localization of histamine receptor subtypes in human inferior turbinates

31 March 2020

1 reference

Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors

31 March 2020

1 reference

Frontiers in pruritus research: scratching the brain for more effective itch therapy

31 March 2020

1 reference

Skin nerve fibres and their contacts with mast cells in patients with palmoplantar pustulosis

31 March 2020

1 reference

Quantitative analysis of tryptase- and chymase-containing mast cells in atopic dermatitis and nummular eczema

31 March 2020

1 reference

Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin.

31 March 2020

1 reference

Chronic urticaria: pathogenesis and treatment

31 March 2020

1 reference

The antipruritic effect of a sedative and a non-sedative antihistamine in atopic dermatitis

31 March 2020

1 reference

The physiological and pathophysiological roles of neuronal histamine: an insight from human positron emission tomography studies

31 March 2020

1 reference

Intrathecal histamine induces spinally mediated behavioral responses through tachykinin NK1 receptors

31 March 2020

1 reference

Histamine, antihistamines and atopic eczema

31 March 2020

1 reference

Mechanism of action of antipruritic drugs

31 March 2020

1 reference

Chlorpheniramine is no more effective than placebo in relieving the symptoms of childhood atopic dermatitis with a nocturnal itching and scratching component

31 March 2020

1 reference

Treatment of itching in atopic eczema with antihistamines with a low sedative profile

31 March 2020

1 reference

Effective treatment of pruritus in atopic dermatitis using H1 antihistamines (second-generation antihistamines): changes in blood histamine and tryptase levels

31 March 2020

1 reference

Failure of terfenadine in relieving the pruritus of atopic dermatitis

31 March 2020

1 reference

An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis

31 March 2020

1 reference

In dermographic urticaria H2 receptor antagonists have a small but therapeutically irrelevant additional effect compared with H1 antagonists alone.

31 March 2020

1 reference

Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb C mice

31 March 2020

1 reference

Participation of histamine H1 and H2 receptors in passive cutaneous anaphylaxis-induced scratching behavior in ICR mice

31 March 2020

1 reference

Evaluation of the effects of anti-pruritic drugs on scratch responses using histamine H1 receptor-deficient mice

31 March 2020

1 reference

The effect of fexofenadine on pruritus in a mouse model (HR-ADf) of atopic dermatitis

31 March 2020

1 reference

Effect of loratadine on mouse models of atopic dermatitis associated pruritus

31 March 2020

1 reference

Beyond the histamine receptor: effect of antihistamines on mast cells

31 March 2020

1 reference

Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses

31 March 2020

1 reference

Molecular cloning of the human histamine H2 receptor

31 March 2020

1 reference

Peripheral and central mediators of itch

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD2465

1 reference

PubMed ID

18172439

Dimensions Publication ID

17 August 2017

0 references

1 reference

PubMed ID

18172439