Lipoprotein-associated phospholipase A2 (Lp-PLA2) as a therapeutic target to prevent retinal vasopermeability during diabetes. (Q37065040)

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13 March 2020

title

Lipoprotein-associated phospholipase A2 (Lp-PLA2) as a therapeutic target to prevent retinal vasopermeability during diabetes (English)

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13 March 2020

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1

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13 March 2020

Philip J. Luthert

10

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13 March 2020

Alan W Stitt

13

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13 March 2020

author name string

Bridget-Ann Kenny

2

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13 March 2020

Vivien Prise

3

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13 March 2020

Josephine Glenn

4

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13 March 2020

Mosharraf H Sarker

5

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13 March 2020

Natalie Hudson

6

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13 March 2020

Martin Brandt

7

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13 March 2020

Francisco J Lopez

8

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13 March 2020

David Gale

9

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13 March 2020

Peter Adamson

11

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13 March 2020

Patric Turowski

12

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13 March 2020

language of work or name

English

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publication date

13 June 2016

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Proceedings of the National Academy of Sciences of the United States of America

13 March 2020

published in

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13 March 2020

volume

113

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13 March 2020

issue

26

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13 March 2020

page(s)

7213-7218

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The progress in understanding and treatment of diabetic retinopathy.

13 March 2020

cites work

1 reference

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Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions

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Antioxidant and inflammatory aspects of lipoprotein-associated phospholipase A₂ (Lp-PLA₂): a review

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Inhibition of lipoprotein-associated phospholipase A2 ameliorates inflammation and decreases atherosclerotic plaque formation in ApoE-deficient mice

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Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies

29 September 2017

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Lipoprotein-associated phospholipase A(2) and atherosclerosis

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LOX-1 augments oxLDL uptake by lysoPC-stimulated murine macrophages but is not required for oxLDL clearance from plasma

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Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development

29 September 2017

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The proangiogenic phenotype of tumor-derived endothelial cells is reverted by the overexpression of platelet-activating factor acetylhydrolase

29 September 2017

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Lysophosphatidylcholine contents in plasma LDL in patients with type 2 diabetes mellitus: relation with lipoprotein-associated phospholipase A2 and effects of simvastatin treatment

29 September 2017

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Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4

29 September 2017

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Transactivation of fetal liver kinase-1/kinase-insert domain-containing receptor by lysophosphatidylcholine induces vascular endothelial cell proliferation

29 September 2017

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Lysophosphatidylcholine increases endothelial permeability: role of PKCalpha and RhoA cross talk

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Genetic difference in susceptibility to the blood-retina barrier breakdown in diabetes and oxygen-induced retinopathy

29 September 2017

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SV40 large T immortalised cell lines of the rat blood-brain and blood-retinal barriers retain their phenotypic and immunological characteristics.

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29 September 2017

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Diabetes and hypercholesterolemia increase blood-brain barrier permeability and brain amyloid deposition: beneficial effects of the LpPLA2 inhibitor darapladib

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The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2.

4 September 2018

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The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man.

4 September 2018

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4 September 2018

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4 September 2018

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RANIBIZUMAB FOR DIABETIC MACULAR EDEMA REFRACTORY TO MULTIPLE PRIOR TREATMENTS.

4 September 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1514213113

Three-Year Outcomes of Individualized Ranibizumab Treatment in Patients with Diabetic Macular Edema

21 January 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1514213113

Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group

21 January 2018

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12 December 2020

Local production of lipoprotein-associated phospholipase A2 and lysophosphatidylcholine in the coronary circulation: association with early coronary atherosclerosis and endothelial dysfunction in humans

1 reference

12 December 2020

Darapladib, a lipoprotein-associated phospholipase A2 inhibitor, in diabetic macular edema: a 3-month placebo-controlled study

1 reference

12 December 2020

Discovery of Potent and Orally Active Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors as a Potential Therapy for Diabetic Macular Edema

1 reference

12 December 2020

Coronary artery disease: Darapladib fails to improve the STABILITY of CAD

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1514213113

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27298369%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27298369%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

PubMed publication ID

27298369

1 reference