Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis (Q37069537)

18 August 2017

5 references

31 July 2019

4 August 2019

15 December 2019

26 August 2020

3 May 2021

Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis (English)

1 reference

18 August 2017

1 reference

3 May 2021

0 references

cell surface receptor

1 reference

31 July 2019

1 reference

4 August 2019

1 reference

15 December 2019

1 reference

26 August 2020

1 reference

3 May 2021

5

Peter P Nawroth

1 reference

18 August 2017

2

Angelika Bierhaus

1 reference

18 August 2017

Christian Bopp

1

1 reference

18 August 2017

Stefan Hofer

3

1 reference

18 August 2017

Axel Bouchon

4

1 reference

18 August 2017

Eike Martin

6

1 reference

18 August 2017

Markus A Weigand

7

1 reference

18 August 2017

language of work or name

1 reference

9 January 2008

6 references

18 August 2017

31 July 2019

4 August 2019

15 December 2019

26 August 2020

3 May 2021

6 references

18 August 2017

31 July 2019

4 August 2019

15 December 2019

26 August 2020

3 May 2021

12

1 reference

18 August 2017

1

1 reference

18 August 2017

201

1 reference

https://scigraph.springernature.com/pub.10.1186/cc6164

18 August 2017

0 references

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The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism

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The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

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RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages

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RAGE: a new pleiotropic antagonistic gene?

29 September 2017

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Expression of receptor for advanced glycation end products (RAGE) and MMP-9 in human pancreatic cancer cells

29 September 2017

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Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response

29 September 2017

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Amphoterin stimulates myogenesis and counteracts the antimyogenic factors basic fibroblast growth factor and S100B via RAGE binding

29 September 2017

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Regulation of monocyte migration by amphoterin (HMGB1).

29 September 2017

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Reversing established sepsis with antagonists of endogenous high-mobility group box 1.

29 September 2017

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Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein

29 September 2017

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S100P stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE)

29 September 2017

1 reference

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Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

29 September 2017

1 reference

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Molecular identification of a danger signal that alerts the immune system to dying cells

29 September 2017

1 reference

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The receptor for advanced glycation end-products (RAGE) directly binds to ERK by a D-domain-like docking site

29 September 2017

1 reference

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TREMs in the immune system and beyond

29 September 2017

1 reference

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Novel strategies for the treatment of sepsis

29 September 2017

1 reference

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The epidemiology of sepsis in the United States from 1979 through 2000

29 September 2017

1 reference

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Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous system

29 September 2017

1 reference

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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.

29 September 2017

1 reference

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Role of Escherichia coli curli operons in directing amyloid fiber formation

29 September 2017

1 reference

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HMGB1 as a late mediator of lethal systemic inflammation

29 September 2017

1 reference

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Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB

29 September 2017

1 reference

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S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles

29 September 2017

1 reference

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The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells

29 September 2017

1 reference

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Role of receptor for advanced glycation end-product (RAGE) and the JAK/STAT-signaling pathway in AGE-induced collagen production in NRK-49F cells

29 September 2017

1 reference

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Toll-like receptors in the induction of the innate immune response

29 September 2017

1 reference

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High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes

29 September 2017

1 reference

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Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

cDNA cloning of a novel secreted isoform of the human receptor for advanced glycation end products and characterization of cells co-expressing cell-surface scavenger receptors and Swedish mutant amyloid precursor protein.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

HMG-1 as a late mediator of endotoxin lethality in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

The myeloperoxidase system of human phagocytes generates Nepsilon-(carboxymethyl)lysine on proteins: a mechanism for producing advanced glycation end products at sites of inflammation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Cell activation by glycated proteins. AGE receptors, receptor recognition factors and functional classification of AGEs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

The S100 family of EF-hand calcium-binding proteins: functions and pathology

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Isolation and some characteristics of an adhesive factor of brain that enhances neurite outgrowth in central neurons

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

RAGE limits regeneration after massive liver injury by coordinated suppression of TNF-alpha and NF-kappaB

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Characterization of allelic and nucleotide variation between the RAGE gene on chromosome 6 and a homologous pseudogene sequence to its 5' regulatory region on chromosome 3: implications for polymorphic studies in diabetes.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Conservation of structural features reveals the existence of a large family of inhibitory cell surface receptors and noninhibitory/activatory counterparts.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation end products

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

The adhesive and neurite-promoting molecule p30: analysis of the amino-terminal sequence and production of antipeptide antibodies that detect p30 at the surface of neuroblastoma cells and of brain neurons

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Contributions of high mobility group box protein in experimental and clinical acute lung injury.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Enhanced expression of receptor for advanced glycation end products in chronic kidney disease

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Receptor for advanced glycation end-products is a marker of type I lung alveolar cells.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Blockade of receptor for advanced glycation end product (RAGE) attenuates ischemia and reperfusion injury to the liver in mice

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Tissue-specific expression patterns of the RAGE receptor and its soluble forms—a result of regulated alternative splicing?

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

ATP gradients inhibit the migratory capacity of specific human dendritic cell types: implications for P2Y11 receptor signaling.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

RAGE and arthritis: the G82S polymorphism amplifies the inflammatory response

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Advanced glycation end products (AGE) and their receptor (RAGE) in the brain of patients with Creutzfeldt-Jakob disease with prion plaques.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Polymorphisms 1704G/T and 2184A/G in the RAGE gene are associated with antioxidant status

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Glutathione-dependent detoxification of alpha-oxoaldehydes by the glyoxalase system: involvement in disease mechanisms and antiproliferative activity of glyoxalase I inhibitors.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2374592

Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface

20 October 2018

1 reference

12 December 2020

Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells

1 reference

12 December 2020

Type II alveolar epithelial cells in lung express receptor for advanced glycation end products (RAGE) gene

1 reference

12 December 2020

Neuron-specific enolase as a marker of fatal outcome in patients with severe sepsis or septic shock

1 reference

12 December 2020

Blockade of RAGE–amphoterin signalling suppresses tumour growth and metastases

1 reference

12 December 2020

Interaction of the receptor for advanced glycation end products (RAGE) with transthyretin triggers nuclear transcription factor kB (NF-kB) activation

1 reference

12 December 2020

HMG-1 as a mediator of acute lung inflammation

1 reference

12 December 2020

Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation

1 reference

12 December 2020

Identifiers

DOI

10.1186/CC6164

1 reference

Dimensions Publication ID

18 August 2017

0 references

1 reference

18 August 2017

1 reference