Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases (Q37079718)

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scientific article published on 06 June 2016

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English	Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases	scientific article published on 06 June 2016

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scholarly article

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Europe PubMed Central

18 August 2017

Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases (English)

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18 August 2017

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Daniel G. Stover

5

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Eric P Winer

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Nancy U Lin

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Jean J Zhao

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Shom Goel

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Shaozhen Xie

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Ian E Krop

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author name string

Jing Ni

1

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7 June 2020

Shakti H Ramkissoon

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7 June 2020

Hanbing Guo

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Victor Luu

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Eugenio Marco

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7 June 2020

Lori A Ramkissoon

9

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Yun Jee Kang

10

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Marika Hayashi

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Quang-De Nguyen

12

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Azra H Ligon

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Elizabeth B Claus

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Brian M Alexander

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Zhigang C Wang

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J Dirk Iglehart

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Thomas M Roberts

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Keith L Ligon

24

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7 June 2020

language of work or name

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6 June 2016

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18 August 2017

Nature Medicine

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7 June 2020

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723-726

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7 June 2020

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Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

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Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets

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Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

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PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting

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Pten loss in Olig2 expressing neural progenitor cells and oligodendrocytes leads to interneuron dysplasia and leukodystrophy

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Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities

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29 September 2017

mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK3CA-mutant breast cancer

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Relevance of PTEN loss in brain metastasis formation in breast cancer patients

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Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis

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Correlative Analysis of Genetic Alterations and Everolimus Benefit in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: Results From BOLERO-2.

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7 January 2021

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Identifiers

10.1038/NM.4120

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7 June 2020

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7 June 2020

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7 June 2020

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