Parasite-derived arginase influences secondary anti-Leishmania immunity by regulating programmed cell death-1-mediated CD4+ T cell exhaustion. (Q37080079)

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scientific article published on 04 March 2013

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English	Parasite-derived arginase influences secondary anti-Leishmania immunity by regulating programmed cell death-1-mediated CD4+ T cell exhaustion.	scientific article published on 04 March 2013

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25 February 2020

Parasite-derived arginase influences secondary anti-Leishmania immunity by regulating programmed cell death-1-mediated CD4+ T cell exhaustion (English)

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25 February 2020

T cell exhaustion

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Stephen M. Beverley

7

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Jude E Uzonna

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Zhirong Mou

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Helen M Muleme

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Dong Liu

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Ping Jia

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25 February 2020

Shiby M Kuriakose

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4 March 2013

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25 February 2020

Journal of Immunology

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25 February 2020

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25 February 2020

3380-3389

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25 February 2020

Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection

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29 September 2017

T cell exhaustion

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29 September 2017

Sphingolipid degradation by Leishmania major is required for its resistance to acidic pH in the mammalian host

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CD8 cells of patients with diffuse cutaneous leishmaniasis display functional exhaustion: the latter is reversed, in vitro, by TLR2 agonists.

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Infection with arginase-deficient Leishmania major reveals a parasite number-dependent and cytokine-independent regulation of host cellular arginase activity and disease pathogenesis

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29 September 2017

Local suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasis

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29 September 2017

Recent advances in arginine metabolism: roles and regulation of the arginases

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Leishmania major phosphoglycans influence the host early immune response by modulating dendritic cell functions

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B7-H1 blockade increases survival of dysfunctional CD8(+) T cells and confers protection against Leishmania donovani infections

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29 September 2017

Programmed death (PD)-1:PD-ligand 1/PD-ligand 2 pathway inhibits T cell effector functions during human tuberculosis

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The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

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29 September 2017

L-arginine availability regulates T-lymphocyte cell-cycle progression

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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

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29 September 2017

Regulation of immune responses by L-arginine metabolism

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29 September 2017

The development of effector and memory T cells in cutaneous leishmaniasis: the implications for vaccine development.

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29 September 2017

Low dose Leishmania major promotes a transient T helper cell type 2 response that is down-regulated by interferon gamma-producing CD8+ T cells

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Arginase: marker, effector, or candidate gene for asthma?

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Arginase 1 overexpression in psoriasis: limitation of inducible nitric oxide synthase activity as a molecular mechanism for keratinocyte hyperproliferation

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29 September 2017

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

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29 September 2017

Genomic organisation and transcription characterisation of the gene encoding Leishmania (Leishmania) amazonensis arginase and its protein structure prediction.

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29 September 2017

The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure.

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29 September 2017

Arginase I: a limiting factor for nitric oxide and polyamine synthesis by activated macrophages?

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29 September 2017

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29 September 2017

Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells

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Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice

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29 September 2017

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27 June 2018

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27 June 2018

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3 September 2018

An effect of parasite-encoded arginase on the outcome of murine cutaneous leishmaniasis

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3 September 2018

Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo.

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3 September 2018

Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites.

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3 September 2018

Arginase plays a pivotal role in polyamine precursor metabolism in Leishmania. Characterization of gene deletion mutants

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3 September 2018

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3 September 2018

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3 September 2018

Persistence without pathology in phosphoglycan-deficient Leishmania major.

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3 September 2018

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3 September 2018

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3 September 2018

The inhibition of arginase by N(omega)-hydroxy-l-arginine controls the growth of Leishmania inside macrophages

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3 September 2018

Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype.

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3 September 2018

The role of IL-10 in promoting disease progression in leishmaniasis

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12 December 2020

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Atypical disseminated leishmaniasis similar to post-kala-azar dermal leishmaniasis in a Brazilian AIDS patient infected with Leishmania (Leishmania) infantum chagasi: a case report

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12 December 2020

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Arginase induction by suppressors of nitric oxide synthesis (IL-4, IL-10 and PGE2) in murine bone-marrow-derived macrophages

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12 December 2020

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N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase

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12 December 2020

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Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines

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12 December 2020

based on heuristic

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Requirement for CD44 in activated T cell extravasation into an inflammatory site

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12 December 2020

based on heuristic

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Determination of arginase activity in macrophages: a micromethod

1 reference

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12 December 2020

based on heuristic

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Repeated inoculation of killed Leishmania major induces durable immune response that protects mice against virulent challenge

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[CD8+ cytotoxic lymphocytes in cutaneous leishmaniasis]

1 reference

https://pubmed.ncbi.nlm.nih.gov/23460745

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis

1 reference

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12 December 2020

based on heuristic

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10.4049/JIMMUNOL.1202537

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25 February 2020

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25 February 2020

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25 February 2020

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