Strategies for the synthesis of the novel antitumor agent peloruside A. (Q37088098)

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3 January 2020

review article

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title

Strategies for the synthesis of the novel antitumor agent peloruside A (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18283613%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

David R Williams

1

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author name string

Partha P Nag

series ordinal

2

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3 January 2020

Nicolas Zorn

series ordinal

3

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3 January 2020

David R Williams

series ordinal

1

1 reference

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3 January 2020

publication date

1 March 2008

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Current Opinion in Drug Discovery and Development

3 January 2020

published in

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3 January 2020

volume

11

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3 January 2020

issue

2

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3 January 2020

page(s)

251-271

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Peloruside A synergizes with other microtubule stabilizing agents in cultured cancer cell lines

3 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693484

Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents

29 September 2017

1 reference

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Natural products as sources of new drugs over the last 25 years

29 September 2017

1 reference

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NMR determination of the bioactive conformation of peloruside A bound to microtubules.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693484

Spatial and temporal variability of cytotoxic metabolites in populations of the New Zealand sponge Mycale hentscheli

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693484

The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693484

Marine natural products as anticancer drugs

29 September 2017

1 reference

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Peloruside A enhances apoptosis in H-ras-transformed cells and is cytotoxic to proliferating T cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693484

Computational comparison of microtubule-stabilising agents laulimalide and peloruside with taxol and colchicine

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693484

Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693484

The immunopharmacology of paclitaxel (Taxol), docetaxel (Taxotere), and related agents

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693484

Synthetic approaches to the microtubule stabilizing agent (-)-laulimalide.

29 September 2017

1 reference

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The chemistry and biology of the bryostatin antitumour macrolides

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693484

The novel cytotoxic sponge metabolite peloruside A, structurally similar to bryostatin-1, has unique bioactivity independent of protein kinase C.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693484

Proline-catalyzed asymmetric aldol reactions between ketones and alpha-unsubstituted aldehydes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693484

The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693484

Peloruside A, an antimitotic agent, specifically decreases tumor necrosis factor-alpha production by lipopolysaccharide-stimulated murine macrophages.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693484

Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693484

Amino acid catalyzed direct asymmetric aldol reactions: a bioorganic approach to catalytic asymmetric carbon-carbon bond-forming reactions

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693484

Peloruside A: a potent cytotoxic macrolide isolated from the new zealand marine sponge Mycale sp

3 September 2018

1 reference

12 December 2020

Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activity

1 reference

12 December 2020

Toward the synthesis of peloruside a: fragment synthesis and coupling studies

1 reference

12 December 2020

Total Synthesis and Absolute Configuration of the Novel Microtubule‐Stabilizing Agent Peloruside A

1 reference

12 December 2020

Toward a total synthesis of peloruside A: enantioselective preparation of the C8-C19 region

1 reference

12 December 2020

Toward the total synthesis of natural peloruside a: stereoselective synthesis of the backbone of the core

1 reference

12 December 2020

Synthesis of the C(1)-C(12) segment of peloruside A by an alpha-benzyloxymethyl ketone aldol strategy

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12 December 2020

Total synthesis of (+)-peloruside A

1 reference

12 December 2020

Synthesis of the C12-C19 fragment of (+)-peloruside A through a diastereomer-discriminating RCM reaction

1 reference

12 December 2020

Stereoselective synthesis of the C(1)-C(11) fragment of peloruside A

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12 December 2020

Shared actions of endotoxin and taxol on TNF receptors and TNF release

1 reference

12 December 2020

Reduction of Carbonyl Compounds with Chiral Oxazaborolidine Catalysts: A New Paradigm for Enantioselective Catalysis and a Powerful New Synthetic Method

1 reference

12 December 2020

An enantioselective synthesis of the C1-C9 segment of antitumor macrolide peloruside A

1 reference

12 December 2020

Synthetic studies of microtubule stabilizing agent peloruside A: an asymmetric synthesis of C10-C24 segment.

1 reference

12 December 2020

Identifiers

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18283613%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

PubMed publication ID

18283613

1 reference