Discovering susceptibility genes for asthma and allergy (Q37095239)

18 August 2017

Discovering susceptibility genes for asthma and allergy (English)

1 reference

18 August 2017

0 references

1

Donata Vercelli

1 reference

18 August 2017

1 March 2008

1 reference

Nature Reviews Immunology

18 August 2017

1 reference

18 August 2017

8

1 reference

18 August 2017

3

1 reference

18 August 2017

169-182

1 reference

https://scigraph.springernature.com/pub.10.1038/nri2257

18 August 2017

0 references

cites work

Asthma genetics and intermediate phenotypes: a review from twin studies

1 reference

Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q

31 March 2020

1 reference

A genome-wide search for quantitative trait loci underlying asthma

31 March 2020

1 reference

Asthma genetics 2006: the long and winding road to gene discovery.

31 March 2020

1 reference

Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci

31 March 2020

1 reference

The future of genetic studies of complex human diseases

31 March 2020

1 reference

Mapping complex disease loci in whole-genome association studies

31 March 2020

1 reference

The immunogenetics of asthma and eczema: a new focus on the epithelium

31 March 2020

1 reference

Time to draw breath: asthma-susceptibility genes are identified

31 March 2020

1 reference

Toward a comprehensive set of asthma susceptibility genes

31 March 2020

1 reference

Asthma genetics: from linear to multifactorial approaches

31 March 2020

1 reference

The future of association studies: gene-based analysis and replication

31 March 2020

1 reference

A Polymorphism* in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E.

31 March 2020

1 reference

Toll-like receptor 2 as a major gene for asthma in children of European farmers

31 March 2020

1 reference

TLR4 gene variants modify endotoxin effects on asthma.

31 March 2020

1 reference

A TLR4 polymorphism is associated with asthma and reduced lipopolysaccharide-induced interleukin-12(p70) responses in Swedish children

31 March 2020

1 reference

Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma

31 March 2020

1 reference

Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease

31 March 2020

1 reference

NOD1 variation, immunoglobulin E and asthma.

31 March 2020

1 reference

Association between polymorphisms in caspase recruitment domain containing protein 15 and allergy in two German populations

31 March 2020

1 reference

NOD-like receptors and human diseases.

31 March 2020

1 reference

TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort

31 March 2020

1 reference

CD14 and toll-like receptor 4: a link between infection and acute coronary events?

31 March 2020

1 reference

Interleukin-10 and transforming growth factor-beta promoter polymorphisms in allergies and asthma

31 March 2020

1 reference

Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma

31 March 2020

1 reference

Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma

31 March 2020

1 reference

An update of the HLA genomic region, locus information and disease associations: 2004.

31 March 2020

1 reference

Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach

31 March 2020

1 reference

Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarization

31 March 2020

1 reference

T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

31 March 2020

1 reference

Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes

31 March 2020

1 reference

TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids

31 March 2020

1 reference

A complete screening of the IL4 gene

31 March 2020

1 reference

A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects

31 March 2020

1 reference

Association between Q551R IL4R genetic variants and atopic asthma risk demonstrated by meta-analysis

31 March 2020

1 reference

A signal transducer and activator of transcription 6 haplotype influences the regulation of serum IgE levels

31 March 2020

1 reference

Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children.

31 March 2020

1 reference

Interleukin-13: central mediator of allergic asthma

31 March 2020

1 reference

Requirement for IL-13 independently of IL-4 in experimental asthma

31 March 2020

1 reference

IL-13 mRNA and immunoreactivity in allergen-induced rhinitis: comparison with IL-4 expression and modulation by topical glucocorticoid therapy

31 March 2020

1 reference

Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells

31 March 2020

1 reference

Expression and localization of the Th2-type cytokine interleukin-13 and its receptor in the placenta during human pregnancy

31 March 2020

1 reference

High IL-13 production by human neonatal T cells: neonate immune system regulator?

31 March 2020

1 reference

Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies

31 March 2020

1 reference

A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children

31 March 2020

1 reference

An IL13 coding region variant is associated with a high total serum IgE level and atopic dermatitis in the German multicenter atopy study (MAS-90)

31 March 2020

1 reference

A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis

31 March 2020

1 reference

Association study of the IL13 variant Arg110Gln in atopic diseases and juvenile idiopathic arthritis

31 March 2020

1 reference

Genetic variants of IL-13 signalling and human asthma and atopy

31 March 2020

1 reference

Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children.

31 March 2020

1 reference

Interleukin-13 gene polymorphism G4257A is associated with atopic dermatitis in Japanese patients

31 March 2020

1 reference

Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program.

31 March 2020

1 reference

An IL-13 promoter polymorphism associated with increased risk of allergic asthma

31 March 2020

1 reference

Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population

31 March 2020

1 reference

Association between an interleukin-13 promoter polymorphism and atopy.

31 March 2020

1 reference

Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study.

31 March 2020

1 reference

Th2 cell-selective enhancement of human IL13 transcription by IL13-1112C>T, a polymorphism associated with allergic inflammation

31 March 2020

1 reference

Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor

31 March 2020

1 reference

Competing Functions Encoded in the Allergy-Associated FcϵRIβ Gene

31 March 2020

1 reference

Polymorphisms in eosinophil pathway genes, asthma and atopy

31 March 2020

1 reference

IL-5 and IL-5 receptor alpha polymorphisms are associated with atopic dermatitis in Koreans

31 March 2020

1 reference

Clara cell 16-kd protein downregulates TH2 differentiation of human naive neonatal T cells

31 March 2020

1 reference

Atopic dermatitis is associated with a functional mutation in the promoter of the C-C chemokine RANTES.

31 March 2020

1 reference

Association of defensin beta-1 gene polymorphisms with asthma

31 March 2020

1 reference

Clara cell protein 16 (CC16) gene polymorphism influences the degree of airway responsiveness in asthmatic children

31 March 2020

1 reference

Variant eotaxin: its effects on the asthma phenotype

31 March 2020

1 reference

Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome

31 March 2020

1 reference

Gene polymorphism in Netherton and common atopic disease

31 March 2020

1 reference

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

31 March 2020

1 reference

Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march.

31 March 2020

1 reference

Filaggrin null mutations are associated with increased asthma severity in children and young adults

31 March 2020

1 reference

Filaggrin mutations in children with severe atopic dermatitis

31 March 2020

1 reference

Lack of filaggrin expression in the human bronchial mucosa

31 March 2020

1 reference

Skin barrier function and allergic risk

31 March 2020

1 reference

Toward a major risk factor for atopic eczema: meta-analysis of filaggrin polymorphism data

31 March 2020

1 reference

Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris.

31 March 2020

1 reference

Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness

31 March 2020

1 reference

Tumour necrosis factor haplotypes and asthma

31 March 2020

1 reference

Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma

31 March 2020

1 reference

Polymorphism at the glutathione S-transferase GSTP1 locus. A new marker for bronchial hyperresponsiveness and asthma

31 March 2020

1 reference

Glutathione S transferase deficiency and passive smoking increase childhood asthma

31 March 2020

1 reference

Association of thromboxane A2 receptor (TBXA2R) with atopy and asthma

31 March 2020

1 reference

Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment

31 March 2020

1 reference

Coding SNP in tenascin-C Fn-III-D domain associates with adult asthma.

31 March 2020

1 reference

Variants of NOS1, NOS2, and NOS3 genes in asthmatics

31 March 2020

1 reference

Pharmacogenetics and asthma: false hope or new dawn?

31 March 2020

1 reference

Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness

31 March 2020

1 reference

Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms.

31 March 2020

1 reference

Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma

31 March 2020

1 reference

It takes a PHD to read the histone code

31 March 2020

1 reference

Positional cloning of a novel gene influencing asthma from chromosome 2q14.

31 March 2020

1 reference

Characterization of a common susceptibility locus for asthma-related traits

31 March 2020

1 reference

Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21

31 March 2020

1 reference

Allele-specific targeting of microRNAs to HLA-G and risk of asthma

31 March 2020

1 reference

Positional identification of an asthma susceptibility gene on human chromosome 5q33.

31 March 2020

1 reference

IRAK-M is involved in the pathogenesis of early-onset persistent asthma

31 March 2020

1 reference

Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis

31 March 2020

1 reference

Framework for a fully powered risk engine

31 March 2020

1 reference

Genetic association studies in Thorax

31 March 2020

1 reference

Replicating genotype-phenotype associations

31 March 2020

1 reference

Comprehensive testing of positionally cloned asthma genes in two populations

31 March 2020

1 reference

Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes

31 March 2020

1 reference

Genetic and environmental effects on complex traits in mice

31 March 2020

1 reference

Gene-environment interactions in asthma and allergies: a new paradigm to understand disease causation

31 March 2020

1 reference

CD14: chaperone or matchmaker?

31 March 2020

1 reference

Double-stranded RNA-mediated TLR3 activation is enhanced by CD14.

31 March 2020

1 reference

A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity

31 March 2020

1 reference

Reduced soluble CD14 levels in amniotic fluid and breast milk are associated with the subsequent development of atopy, eczema, or both.

31 March 2020

1 reference

Association between farm exposure and atopy, according to the CD14 C-159T polymorphism

31 March 2020

1 reference

The -159 C-->T polymorphism of CD14 is associated with nonatopic asthma and food allergy

31 March 2020

1 reference

Evaluation of the CD14 C-159 T polymorphism in the German Multicenter Allergy Study cohort

31 March 2020

1 reference

A promoter polymorphism in the CD14 gene is associated with elevated levels of soluble CD14 but not with IgE or atopic diseases

31 March 2020

1 reference

The CD14 C-159T polymorphism is not associated with asthma or asthma severity in an Australian adult population.

31 March 2020

1 reference

Genetics, epigenetics, and the environment: switching, buffering, releasing

31 March 2020

1 reference

Opposite effects of CD 14/-260 on serum IgE levels in children raised in different environments.

31 March 2020

1 reference

Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study

31 March 2020

1 reference

Effects of dog ownership and genotype on immune development and atopy in infancy

31 March 2020

1 reference

Endotoxin Exposure, CD14, and Allergic Disease

31 March 2020

1 reference

Genome screen for asthma and bronchial hyperresponsiveness: interactions with passive smoke exposure.

31 March 2020

1 reference

The sex-specific genetic architecture of quantitative traits in humans

31 March 2020

1 reference

Learning from discrepancies: CD14 polymorphisms, atopy and the endotoxin switch.

31 March 2020

1 reference

IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma

31 March 2020

1 reference

Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma

31 March 2020

1 reference

Gene-gene interactions for asthma and plasma total IgE concentration in Chinese children

31 March 2020

1 reference

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

31 March 2020

1 reference

Genome-wide association studies for common diseases and complex traits

31 March 2020

1 reference

A haplotype map of the human genome

31 March 2020

1 reference

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

31 March 2020

1 reference

The Faustian bargain of genetic association studies: bigger might not be better, or at least it might not be good enough

31 March 2020

1 reference

What Genome-wide Association Studies Can Do for Medicine

31 March 2020

1 reference

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

31 March 2020

1 reference

Quantitative genetic variation: a post-modern view

31 March 2020

1 reference

Toward Asthma Prevention — Does All That Really Matters Happen before We Learn to Read?

31 March 2020

1 reference

Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children

31 March 2020

1 reference

Age-specific relationship between CD14 and atopy in a cohort assessed from age 8 to 25 years

31 March 2020

1 reference

Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation

31 March 2020

1 reference

Hsp90 as a capacitor for morphological evolution

31 March 2020

1 reference

Hsp90 as a capacitor of phenotypic variation

31 March 2020

1 reference

Transgenerational response to nutrition, early life circumstances and longevity.

31 March 2020

1 reference

The human IL-13 locus in neonatal CD4+ T cells is refractory to the acquisition of a repressive chromatin architecture.

31 March 2020

1 reference

DNA methylation changes at human Th2 cytokine genes coincide with DNase I hypersensitive site formation during CD4(+) T cell differentiation.

31 March 2020

1 reference

Histone acetylation and deacetylation: importance in inflammatory lung diseases

31 March 2020

1 reference

Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy.

31 March 2020

1 reference

Identifying novel genes contributing to asthma pathogenesis

31 March 2020

1 reference

A polymorphism in the coding region of interleukin-13 gene is associated with atopy but not asthma in Chinese children

31 March 2020

1 reference

Functional effect of the R110Q IL13 genetic variant alone and in combination with IL4RA genetic variants

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI2257

1 reference

PubMed ID

18301422

Dimensions Publication ID

18 August 2017

0 references

1 reference

PubMed ID

18301422