Current management and challenges of malignant disease in the CNS in paediatric leukaemia (Q37097413)

18 August 2017

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title

Current management and challenges of malignant disease in the CNS in paediatric leukaemia (English)

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18 August 2017

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1

Ching-Hon Pui

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18 August 2017

Scott C Howard

2

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18 August 2017

1 March 2008

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Lancet Oncology Commission

18 August 2017

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18 August 2017

9

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18 August 2017

257-268

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18 August 2017

3

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Treatment of acute lymphoblastic leukemia

18 August 2017

1 reference

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7 January 2021

Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) acute lymphoblastic leukemia studies, 1982-1995.

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7 January 2021

Diagnostic cerebrospinal fluid examination in children with acute lymphoblastic leukemia: significance of low leukocyte counts with blasts or traumatic lumbar puncture

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7 January 2021

Children's Cancer Group trials in childhood acute lymphoblastic leukemia: 1983-1995.

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7 January 2021

Thioguanine offers no advantage over mercaptopurine in maintenance treatment of childhood ALL: results of the randomized trial COALL-92.

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7 January 2021

BFM-oriented treatment for children with acute lymphoblastic leukemia without cranial irradiation and treatment reduction for standard risk patients: results of DCLSG protocol ALL-8 (1991-1996).

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7 January 2021

Results of the Dana-Farber Cancer Institute ALL Consortium Protocol 95-01 for children with acute lymphoblastic leukemia

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7 January 2021

Long-term results of three randomized trials (58831, 58832, 58881) in childhood acute lymphoblastic leukemia: a CLCG-EORTC report. Children Leukemia Cooperative Group.

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7 January 2021

Improving outcome through two decades in childhood ALL in the Nordic countries: the impact of high-dose methotrexate in the reduction of CNS irradiation. Nordic Society of Pediatric Haematology and Oncology (NOPHO).

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7 January 2021

Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children's Research Hospital

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7 January 2021

Benefit of dexamethasone compared with prednisolone for childhood acute lymphoblastic leukaemia: results of the UK Medical Research Council ALL97 randomized trial

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7 January 2021

Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial

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7 January 2021

Treatment and long-term results in children with acute myeloid leukaemia treated according to the AIEOP AML protocols.

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7 January 2021

Treatment strategies and long-term results in paediatric patients treated in four consecutive AML-BFM trials

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7 January 2021

Long-term results of children with acute myeloid leukemia: a report of three consecutive Phase III trials by the Children's Cancer Group: CCG 251, CCG 213 and CCG 2891.

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https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Treatment strategy and results in children treated on three Dutch Childhood Oncology Group acute myeloid leukemia trials.

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7 January 2021

Results of 58872 and 58921 trials in acute myeloblastic leukemia and relative value of chemotherapy vs allogeneic bone marrow transplantation in first complete remission: the EORTC Children Leukemia Group report

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https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Treatment strategy and long-term results in pediatric patients treated in two consecutive AML-GATLA trials

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7 January 2021

Treatment of childhood acute myeloblastic leukemia: dose intensification improves outcome and maintenance therapy is of no benefit--multicenter studies of the French LAME (Leucémie Aiguë Myéloblastique Enfant) Cooperative Group

1 reference

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7 January 2021

Long-term results in children with AML: NOPHO-AML Study Group--report of three consecutive trials

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7 January 2021

Acute myelogenous leukemia in Chile PINDA protocols 87 and 92 results

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7 January 2021

Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): a review of four consecutive childhood AML trials conducted between 1981 and 2000.

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7 January 2021

Twenty years of Polish experience with three consecutive protocols for treatment of childhood acute myelogenous leukemia.

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7 January 2021

Successive clinical trials for childhood acute myeloid leukemia at St Jude Children's Research Hospital, from 1980 to 2000.

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7 January 2021

Repetitive cycles of high-dose cytarabine are effective for childhood acute myeloid leukemia: long-term outcome of the children with AML treated on two consecutive trials of Tokyo Children's Cancer Study Group.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Improved treatment results for childhood acute myeloid leukemia in Taiwan.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Treatment strategy and long-term results in paediatric patients treated in consecutive UK AML trials

1 reference

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7 January 2021

Double-delayed intensification improves event-free survival for children with intermediate-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Intensification of Therapy for Children With Lower-Risk Acute Lymphoblastic Leukemia: Long-Term Follow-Up of Patients Treated on Children’s Cancer Group Trial 1881

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Isolated CNS relapse of acute lymphoblastic leukemia treated with intensive systemic chemotherapy and delayed CNS radiation: a pediatric oncology group study.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Central nervous system disease in acute lymphoblastic leukemia: prophylaxis and treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Analysis of prognostic factors of acute lymphoblastic leukemia in infants: report on CCG 1953 from the Children's Oncology Group

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Low leukocyte counts with blast cells in cerebrospinal fluid of children with newly diagnosed acute lymphoblastic leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Low numbers of CSF blasts at diagnosis do not predict for the development of CNS leukemia in children with intermediate-risk acute lymphoblastic leukemia: a Childrens Cancer Group report

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Prognostic significance of blasts in the cerebrospinal fluid without pleiocytosis or a traumatic lumbar puncture in children with acute lymphoblastic leukemia: experience of the Dutch Childhood Oncology Group.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

CSF flow cytometry greatly improves diagnostic accuracy in CNS hematologic malignancies

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Risk factors for traumatic and bloody lumbar puncture in children with acute lymphoblastic leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Safety of lumbar puncture for children with acute lymphoblastic leukemia and thrombocytopenia.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Role of cranial radiotherapy for childhood T-cell acute lymphoblastic leukemia with high WBC count and good response to prednisone. Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Münster groups.

1 reference

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7 January 2021

Pharmacogenetics of outcome in children with acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

High interleukin-15 expression characterizes childhood acute lymphoblastic leukemia with involvement of the CNS

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Risk factors and therapy for isolated central nervous system relapse of pediatric acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Clinical significance of central nervous system involvement at diagnosis of pediatric acute myeloid leukemia: a single institution's experience

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Extended follow-up of long-term survivors of childhood acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Cumulative incidence of secondary neoplasms as a first event after childhood acute lymphoblastic leukemia

1 reference

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7 January 2021

Medical assessment of adverse health outcomes in long-term survivors of childhood cancer

1 reference

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7 January 2021

Neuropsychological outcomes from a randomized trial of triple intrathecal chemotherapy compared with 18 Gy cranial radiation as CNS treatment in acute lymphoblastic leukemia: findings from Dana-Farber Cancer Institute ALL Consortium Protocol 95-01.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Tumors of the brain and nervous system after radiotherapy in childhood

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Outcomes of a randomized trial of hyperfractionated cranial radiation therapy for treatment of high-risk acute lymphoblastic leukemia: therapeutic efficacy and neurotoxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Pilot studies of species-specific chemotherapy of childhood acute lymphoblastic leukemia using genotype and immunophenotype

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https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

An intensive re-treatment protocol for children with an isolated CNS relapse of acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Improved survival of children with isolated CNS relapse of acute lymphoblastic leukemia: a pediatric oncology group study .

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Does cranial irradiation reduce the risk for bone marrow relapse in acute myelogenous leukemia? Unexpected results of the Childhood Acute Myelogenous Leukemia Study BFM-87.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Effect of body position on ventricular CSF methotrexate concentration following intralumbar administration

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Effect of probenecid on ventricular cerebrospinal fluid methotrexate pharmacokinetics after intralumbar administration in nonhuman primates

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Schedule-dependent synergism and antagonism between methotrexate and cytarabine against human leukemia cell lines in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Intrathecal triple therapy decreases central nervous system relapse but fails to improve event-free survival when compared with intrathecal methotrexate: results of the Children's Cancer Group (CCG) 1952 study for standard-risk acute lymphoblastic l

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Phase I trial of intrathecal liposomal cytarabine in children with neoplastic meningitis

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https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

A pharmacokinetic study of intra-CSF administered encapsulated cytarabine (DepoCyt) for the treatment of neoplastic meningitis in patients with leukemia, lymphoma, or solid tumors as part of a phase III study

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Feasibility and toxicity of intrathecal liposomal cytarabine in 5 children and young adults with refractory neoplastic meningitis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Comparison of the force required for dural puncture with different spinal needles and subsequent leakage of cerebrospinal fluid.

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https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Complications after LP related to needle type: pencil-point versus Quincke

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https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Thrombosis of the cerebral veins and sinuses

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https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Childhood central nervous system leukemia: historical perspectives, current therapy, and acute neurological sequelae

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https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

CNS-Directed Therapy for Childhood Acute Lymphoblastic Leukemia: Childhood ALL Collaborative Group Overview of 43 Randomized Trials

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https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Is mega dose of methotrexate beneficial to patients with acute lymphoblastic leukemia?

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

No advantage of dexamethasone over prednisolone for the outcome of standard- and intermediate-risk childhood acute lymphoblastic leukemia in the Tokyo Children's Cancer Study Group L95-14 protocol

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Substitution of oral and intravenous thioguanine for mercaptopurine in a treatment regimen for children with standard risk acute lymphoblastic leukemia: a collaborative Children's Oncology Group/National Cancer Institute pilot trial (CCG-1942).

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Submicroscopic bone marrow involvement in isolated extramedullary relapses in childhood acute lymphoblastic leukemia: a more precise definition of "isolated" and its possible clinical implications, a collaborative study of the Resistant Disease Comm

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

Comparison of maintenance treatment regimens for first central nervous system relapse in children with acute lymphocytic leukemia. A Pediatric Oncology Group study

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7 January 2021

Survival outcome after the first central nervous system relapse in children with acute lymphoblastic leukemia: a retrospective analysis of 79 patients in a joint program involving the experience of three Japanese study groups

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2808%2970070-6

7 January 2021

10.1016/S1470-2045(08)70070-6

Identifiers

DOI

1 reference

18 August 2017

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PubMed ID

18308251