Archaeosome adjuvants: immunological capabilities and mechanism(s) of action (Q37111161)

18 August 2017

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title

Archaeosome adjuvants: immunological capabilities and mechanism(s) of action (English)

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18 August 2017

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Lakshmi Krishnan

1

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PubMed ID

18343538

18 August 2017

G Dennis Sprott

series ordinal

2

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PubMed ID

18343538

18 August 2017

language of work or name

English

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publication date

27 February 2008

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18 August 2017

13

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based on heuristic

inferred from page(s)

published in

Vaccine

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18 August 2017

26

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18 August 2017

17

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18 August 2017

2043-2055

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Memory T cells and vaccines

18 August 2017

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Recent advances in the discovery and delivery of vaccine adjuvants

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Archaeobacterial ether lipid liposomes as vaccine adjuvants

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

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Rapid clonal expansion and prolonged maintenance of memory CD8+ T cells of the effector (CD44highCD62Llow) and central (CD44highCD62Lhigh) phenotype by an archaeosome adjuvant independent of TLR2

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A structural comparison of the total polar lipids from the human archaea Methanobrevibacter smithii and Methanosphaera stadtmanae and its relevance to the adjuvant activities of their liposomes

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Archaeosome vaccine adjuvants induce strong humoral, cell-mediated, and memory responses: comparison to conventional liposomes and alum

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Archaeosomes varying in lipid composition differ in receptor-mediated endocytosis and differentially adjuvant immune responses to entrapped antigen

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Liposome adjuvants prepared from the total polar lipids of Haloferax volcanii, Planococcus spp. and Bacillus firmus differ in ability to elicit and sustain immune responses

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Archaeosomes as adjuvants for combination vaccines.

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Archaeosomes induce long-term CD8+ cytotoxic T cell response to entrapped soluble protein by the exogenous cytosolic pathway, in the absence of CD4+ T cell help.

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Phosphatidylserine receptor-mediated recognition of archaeosome adjuvant promotes endocytosis and MHC class I cross-presentation of the entrapped antigen by phagosome-to-cytosol transport and classical processing.

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Immunization of mice with lipopeptide antigens encapsulated in novel liposomes prepared from the polar lipids of various Archaeobacteria elicits rapid and prolonged specific protective immunity against infection with the facultative intracellular pa

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Archaeosomes as self-adjuvanting delivery systems for cancer vaccines

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Activation of dendritic cells by liposomes prepared from phosphatidylinositol mannosides from Mycobacterium bovis bacillus Calmette-Guerin and adjuvant activity in vivo.

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Phagosomes are competent organelles for antigen cross-presentation

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Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens

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Liposome-encapsulated CpG oligodeoxynucleotides as a potent adjuvant for inducing type 1 innate immunity

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Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells.

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Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro

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The potent adjuvant activity of archaeosomes correlates to the recruitment and activation of macrophages and dendritic cells in vivo

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Short-term repeated-dose toxicity profile of archaeosomes administered to mice via intravenous and oral routes

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Complete polar lipid composition of Thermoplasma acidophilum HO-62 determined by high-performance liquid chromatography with evaporative light-scattering detection.

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7 January 2021

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Identifiers

DOI

10.1016/J.VACCINE.2008.02.026

1 reference

18 August 2017

1 reference

PubMed ID

18343538