Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models (Q37112122)

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19 January 2020

title

Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models (English)

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19 January 2020

0 references

1

1 reference

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19 January 2020

Miriam A Hickey

series ordinal

2

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19 January 2020

5

Karen Reue

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19 January 2020

author name string

Peixiang Zhang

series ordinal

3

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19 January 2020

Marie-Francoise Chesselet

series ordinal

4

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19 January 2020

publication date

5 January 2009

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19 January 2020

published in

Human Molecular Genetics

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19 January 2020

volume

18

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19 January 2020

issue

6

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19 January 2020

page(s)

1006-1016

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Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice

19 January 2020

cites work

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Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies.

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Adipose tissue hormones and the regulation of food intake

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Peroxisome Proliferator-Activated Receptor-gamma in Amyotrophic Lateral Sclerosis and Huntington's Disease

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Adipokines and the peripheral and neural control of energy balance

14 September 2017

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Obesity and lipodystrophy--where do the circles intersect?

14 September 2017

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Increased metabolism in the R6/2 mouse model of Huntington's disease.

14 September 2017

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Transcriptional signatures in Huntington's disease

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14 September 2017

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14 September 2017

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Central nervous system control of food intake and body weight

14 September 2017

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Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway

14 September 2017

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Mechanisms of disease: Histone modifications in Huntington's disease

14 September 2017

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Hypothalamic-endocrine aspects in Huntington's disease.

14 September 2017

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Metabolic consequences of lipodystrophy in mouse models.

14 September 2017

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Adipose tissue: from lipid storage compartment to endocrine organ

14 September 2017

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The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies

14 September 2017

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Metabolic control through the PGC-1 family of transcription coactivators

14 September 2017

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Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease.

14 September 2017

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Adipose tissue, inflammation, and cardiovascular disease

14 September 2017

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PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

14 September 2017

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Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

14 September 2017

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A cell-based screen for drugs to treat Huntington's disease

14 September 2017

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Acquired and inherited lipodystrophies

14 September 2017

1 reference

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Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats

14 September 2017

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Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes

14 September 2017

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

14 September 2017

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

14 September 2017

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Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

14 September 2017

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Rosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtin-expressing cells: possible role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in the pathogenesis of Huntington disease

14 September 2017

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In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets

27 June 2018

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The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis

27 June 2018

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Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro.

27 June 2018

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Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease

27 June 2018

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Safety testing of tebufenozide, a new molt-inducing insecticide, for effects on nontarget forest soil invertebrates

27 June 2018

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Body weight and dietary factors in Huntington's disease patients compared with matched controls

27 June 2018

1 reference

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An anthropometric assessment of Huntington's disease patients and families

27 June 2018

1 reference

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Nutritional evaluation of Huntington disease patients

27 June 2018

1 reference

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Factors associated with slow progression in Huntington's disease

27 June 2018

1 reference

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Glucose homeostasis in Huntington disease: abnormalities in insulin sensitivity and early-phase insulin secretion

27 June 2018

1 reference

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The metabolic profile of early Huntington's disease--a combined human and transgenic mouse study

3 September 2018

1 reference

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The ratio of leptin to adiponectin can be used as an index of insulin resistance

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2649017

Impaired glucose tolerance in the R6/1 transgenic mouse model of Huntington's disease.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2649017

Leptin-to-adiponectin ratio as independent predictor of insulin sensitivity during growth in overweight Hispanic youth.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2649017

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2649017

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

3 September 2018

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Early behavioral deficits in R6/2 mice suitable for use in preclinical drug testing

3 September 2018

1 reference

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Gene expression in Huntington's disease skeletal muscle: a potential biomarker

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2649017

Mutant huntingtin affects the rate of transcription of striatum-specific isoforms of phosphodiesterase 10A.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2649017

Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic mice

3 September 2018

1 reference

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Progressive abnormalities in skeletal muscle and neuromuscular junctions of transgenic mice expressing the Huntington's disease mutation

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2649017

Circulating and cerebrospinal fluid ghrelin and leptin: potential role in altered body weight in Huntington's disease

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2649017

Assessment of the nutrition status of patients with Huntington's disease.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2649017

Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2649017

Weight loss in early stage of Huntington's disease

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2649017

Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2649017

Weight loss in Huntington's disease

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2649017

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2649017

Adipose tissue as an endocrine organ

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19124532

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Abnormalities in the functioning of adipocytes from R6/2 mice that are transgenic for the Huntington's disease mutation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19124532

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Leptin:adiponectin ratio is an independent predictor of intima media thickness of the common carotid artery

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19124532

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDN428

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19124532%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19124532%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference