Protein kinase inhibitors: probes for the functions of protein phosphorylation (Q37115205)

18 August 2017

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title

Protein kinase inhibitors: probes for the functions of protein phosphorylation (English)

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18 August 2017

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Casnellie JE

1

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18 August 2017

publication date

1 January 1991

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18 August 2017

published in

Advances in Pharmacology

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18 August 2017

volume

22

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18 August 2017

page(s)

167-205

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A protein kinase C pseudosubstrate peptide inhibits phosphorylation of the CD3 antigen in streptolysin-O-permeabilized human T lymphocytes

18 August 2017

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Protein kinase C inhibitor H-7 alters the actin cytoskeleton of cultured cells

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Alkyl-linked diglycerides inhibit protein kinase C activation by diacylglycerols

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Effects of the tyrosine-kinase inhibitor genistein on DNA synthesis and phospholipid-derived second messenger generation in mouse 10T1/2 fibroblasts and rat liver T51B cells

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Isolation and properties of the rabbit skeletal muscle protein inhibitor of adenosine 3',5'-monophosphate dependent protein kinases

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Interaction of cAMP Derivatives with the 'Stable' CAMP-Binding Site in the CAMP-Dependent Protein Kinase Type I

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Staurosporine stimulates expression of the urokinase-type (u-PA) plasminogen activator in LLC-PK1 cells

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A pseudosubstrate peptide inhibits protein kinase C-mediated phosphorylation in permeabilized Rat-1 cells

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K252a is a potent and selective inhibitor of phosphorylase kinase

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7 January 2021

Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships

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Tyrosine phosphorylation is an early and specific event involved in primary keratinocyte differentiation

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Characterization of receptor tyrosine-specific protein kinases by the use of inhibitors. Staurosporine is a 100-times more potent inhibitor of insulin receptor than IGF-I receptor.

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Effects of herbimycin A and various SH-reagents on p60v-src kinase activity in vitro

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7 January 2021

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors

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7 January 2021

Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor

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Inhibition of protein-tyrosine kinase activity by flavanoids and related compounds

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7 January 2021

Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor

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7 January 2021

Tyrosine phosphorylation in human neutrophil

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7 January 2021

The effect of quercetin on the phosphorylatio activity of the Rous sarcoma virus transforming gene product in vitro and in vivo

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7 January 2021

Characterization of specific [3H]dimethylstaurosporine binding to protein kinase C.

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7 January 2021

Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin

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7 January 2021

Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases.

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The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

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Functions of sphingolipids and sphingolipid breakdown products in cellular regulation

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Suramin, an anti-cancer drug, inhibits protein kinase C and induces differentiation in neuroblastoma cell clone NB2A

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7 January 2021

Characterization of specific binding sites for [3H]-staurosporine on various protein kinases

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Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

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7 January 2021

Molecular pharmacology of protein kinases

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PDGF-induced activation of phospholipase C is not required for induction of DNA synthesis

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Protein kinase C contains a pseudosubstrate prototope in its regulatory domain

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Protein tyrosine phosphorylation in rabbit peritoneal neutrophils

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7 January 2021

A thousand and one protein kinases

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Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities

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7 January 2021

Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures

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7 January 2021

Kinetic studies of tyrosine kinase inhibition by erbstatin

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7 January 2021

Effective synthesis of erbstatin and its analogs

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7 January 2021

Inhibition of tyrosine protein kinase by synthetic erbstatin analogs

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7 January 2021

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction

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7 January 2021

K-252a, a potent inhibitor of protein kinase C from microbial origin

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7 January 2021

K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

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7 January 2021

Inhibition by adriamycin of calmodulin-sensitive and phospholipid-sensitive calcium-dependent phosphorylation of endogenous proteins from heart

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7 January 2021

Inhibition by melittin of phospholipid-sensitive and calmodulin-sensitive Ca2+-dependent protein kinases

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7 January 2021

Active site-directed inhibition of Ca2+/calmodulin-dependent protein kinase type II by a bifunctional calmodulin-binding peptide

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7 January 2021

Genistein-induced cell differentiation and protein-linked DNA strand breakage in human melanoma cells

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7 January 2021

The protein kinase C family: heterogeneity and its implications

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Staurosporine, a potent protein kinase C inhibitor, fails to inhibit 12-O-tetradecanoylphorbol-13-acetate-caused ornithine decarboxylase induction in isolated mouse epidermal cells

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7 January 2021

UCN-1028A, a novel and specific inhibitor of protein kinase C, from Cladosporium

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7 January 2021

Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities

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Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

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Historical perspectives on protein phosphorylation and a classification system for protein kinases

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Synthesis and evaluation of multisubstrate inhibitors of an oncogene-encoded tyrosine-specific protein kinase. 1.

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Phospholipid/calcium-dependent protein kinase (protein kinase C) system: a major site of bioregulation

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Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor tyrosine kinase activity

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Effects of H-7 are not exclusively mediated through protein kinase C or the cyclic nucleotide-dependent kinases

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7 January 2021

Polymyxin B is a more selective inhibitor for phospholipid-sensitive Ca2+-dependent protein kinase than for calmodulin-sensitive Ca2+-dependent protein kinase

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7 January 2021

Phospholipid-sensitive Ca2+-dependent protein kinase inhibition by R-24571, a calmodulin antagonist

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7 January 2021

Ribofuranosyl-benzimidazole derivatives as inhibitors of casein kinase-2 and casein kinase-1.

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A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity

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Interleukin-2 induces proliferation of T lymphocyte mutants lacking protein kinase C

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T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation

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7 January 2021

Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action

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7 January 2021

The structure of an epidermal growth factor-receptor kinase inhibitor, erbstatin

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7 January 2021

Phorbol diester receptor copurifies with protein kinase C

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7 January 2021

Studies and perspectives of protein kinase C.

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7 January 2021

Modulation of cellular processes by H7, a non-selective inhibitor of protein kinases

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7 January 2021

A kinetic study of interactions of (RP)- and (SP)-adenosine cyclic 3',5'-phosphorothioates with type II bovine cardiac muscle adenosine cyclic 3',5'-phosphate dependent protein kinase

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7 January 2021

Binding of protein kinase C to napthalenesulfonamide- and phenothiazine-agarose columns: evidence for direct interactions between protein kinase C and cationic amphiphilic inhibitors of the enzyme

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7 January 2021

A specific inhibitor for tyrosine protein kinase from Pseudomonas

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7 January 2021

Inhibition of tyrosine protein kinase activity by synthetic isoflavones and flavones

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7 January 2021

Effect of genistein on topoisomerase activity and on the growth of [Val 12]Ha-ras-transformed NIH 3T3 cells

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7 January 2021

Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus

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7 January 2021

A new biological role of sangivamycin; inhibition of protein kinases

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7 January 2021

A new inhibitor of protein kinase C, RK-286C (4'-demethylamino-4'-hydroxystaurosporine). I. Screening, taxonomy, fermentation and biological activity.

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7 January 2021

Inhibition of protein kinase C by antineoplastic agents: implications for drug resistance.

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7 January 2021

Protein kinase C--a family affair

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7 January 2021

Tyrphostins inhibit the epidermal growth factor receptor-mediated breakdown of phosphoinositides

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7 January 2021

Erbstatin blocks platelet activating factor-induced protein-tyrosine phosphorylation, polyphosphoinositide hydrolysis, protein kinase C activation, serotonin secretion and aggregation of rabbit platelets

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7 January 2021

Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells

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7 January 2021

Phospholipid-sensitive calcium-dependent protein kinase: Inhibition by antipsychotic drugs

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7 January 2021

Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase

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7 January 2021

Amino acid sequence of the heat-stable inhibitor of the cAMP-dependent protein kinase from rabbit skeletal muscle

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7 January 2021

Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase

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7 January 2021

Inhibition of insulin-dependent lipogenesis and anti-lipolysis by protein tyrosine kinase inhibitors.

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7 January 2021

A synthetic peptide of the pseudosubstrate domain of protein kinase C blocks cytoplasmic alkalinization during activation of the sea urchin egg

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7 January 2021

Specific inhibitors of tyrosine-specific protein kinase, synthetic 4-hydroxycinnamamide derivatives

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7 January 2021

Specific inhibitors of tyrosine-specific protein kinase. I. Synthesis and inhibitory activities of .ALPHA.-cyanocinnamamides

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7 January 2021

A tyrosine-specific protein kinase inhibitor, alpha-cyano-3-ethoxy-4-hydroxy-5-phenylthiomethylcinnamamide, blocks the phosphorylation of tyrosine kinase substrate in intact cells.

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7 January 2021

Inhibition of phosphorylase kinase, and tyrosine protein kinase activities by quercetin.

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7 January 2021

Effect of tamoxifen, a nonsteroidal antiestrogen, on phospholipid/calcium-dependent protein kinase and phosphorylation of its endogenous substrate proteins from the rat brain and ovary

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7 January 2021

Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity

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7 January 2021

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities

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7 January 2021

Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase

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7 January 2021

Contrasting effects of the protein kinase C inhibitor, staurosporine, on cytokine and phorbol ester stimulation of fructose 2,6-bisphosphate and prostaglandin E production by fibroblasts in vitro. Comparative studies using interleukin-1 alpha, tumou

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7 January 2021

cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes

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7 January 2021

Antineoplastic effect of erbstatin on human mammary and esophageal tumors in athymic nude mice.

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7 January 2021

Use and selectivity of herbimycin A as inhibitor of protein-tyrosine kinases

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7 January 2021

Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus

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7 January 2021

Inhibition of transforming activity of tyrosine kinase oncogenes by herbimycin A.

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7 January 2021

Irreversible inhibition of v-src tyrosine kinase activity by herbimycin A and its abrogation by sulfhydryl compounds

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7 January 2021

Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960035-6

7 January 2021

Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960035-6

7 January 2021

Protein kinase C is required for responses to T cell receptor ligands but not to interleukin-2 in T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960035-6

7 January 2021

Profiling of inhibitors of protein kinase C

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960035-6

7 January 2021

Sphingosine interacts directly with the receptor complex to inhibit thyrotropin-releasing hormone binding

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960035-6

7 January 2021

Modes of inhibition by acylcarnitines, adriamycin and trifluoperazine of cardiac phospholipid-sensitive calcium-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960035-6

7 January 2021

Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960035-6

7 January 2021

Induction of mammalian topoisomerase II dependent DNA cleavage by nonintercalative flavonoids, genistein and orobol

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960035-6

7 January 2021

10.1016/S1054-3589(08)60035-6

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