Genetic mutations that prevent pain: implications for future pain medication (Q37120834)

18 August 2017

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title

Genetic mutations that prevent pain: implications for future pain medication (English)

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18 August 2017

Jörn Lötsch

2

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author name string

Bruno Oertel

series ordinal

1

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18 August 2017

publication date

1 February 2008

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18 August 2017

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18 August 2017

volume

9

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18 August 2017

issue

2

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18 August 2017

page(s)

179-194

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https://api.crossref.org/works/10.2217%2F14622416.9.2.179

18 August 2017

1 reference

Congenital insensitivity to pain. A clinical, genetic and neurophysiological study of four children from the same family.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

The genetics of pain and pain inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

The Sequence of the Human Genome

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Initial sequencing and analysis of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Genetic predictors for acute experimental cold and heat pain sensitivity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Evidence for morphine-independent central nervous opioid effects after administration of codeine: contribution of other codeine metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

The search for migraine genes: an overview of current knowledge.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Mechanisms of Disease: genetics of fibromyalgia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

The genetic mediation of individual differences in sensitivity to pain and its inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

An SCN9A channelopathy causes congenital inability to experience pain

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Congenital insensitivity to pain: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

The gene for hereditary sensory neuropathy type I (HSN-I) maps to chromosome 9q22.1-q22.3.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Fine mapping of the hereditary sensory neuropathy type I locus on chromosome 9q22.1-->q22.3: exclusion of GAS1 and XPA.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

SPTLC1 is mutated in hereditary sensory neuropathy, type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

SPTLC1 mutation in twin sisters with hereditary sensory neuropathy type I

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Identification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the Study of Canadian Genetic Isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

A mutation in the HSN2 gene causes sensory neuropathy type II in a Lebanese family

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

New HSN2 mutation in Japanese patient with hereditary sensory and autonomic neuropathy type 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Localization of the gene for familial dysautonomia on chromosome 9 and definition of DNA markers for genetic diagnosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Transcription impairment and cell migration defects in elongator-depleted cells: implication for familial dysautonomia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Familial dysautonomia is caused by mutations of the IKAP gene

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Identification of the first non-Jewish mutation in familial Dysautonomia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Mutation and polymorphism analysis of the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor in congenital insensitivity to pain with anhidrosis (CIPA) families.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli-Bedouins: genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Assessment and evaluation of hereditary sensory and autonomic neuropathies with autonomic and neurophysiological examinations

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

The human mu-opioid receptor gene polymorphism 118A > G decreases cortical activation in response to specific nociceptive stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Functional coupling of a mu opioid receptor to G proteins and adenylyl cyclase: modulation by chronic morphine treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Human opioid receptor A118G polymorphism affects intravenous patient-controlled analgesia morphine consumption after total abdominal hysterectomy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Association of mu-opioid receptor gene polymorphism (A118G) with variations in morphine consumption for analgesia after total knee arthroplasty

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

The mu-opioid receptor gene polymorphism 118A>G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Pharmacokinetic-pharmacodynamic modeling of morphine-6-glucuronide-induced analgesia in healthy volunteers: absence of sex differences

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Polymorphism of mu-opioid receptor gene (OPRM1:c.118A>G) does not protect against opioid-induced respiratory depression despite reduced analgesic response.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Sequence Variability and Candidate Gene Analysis in Two Cancer Patients with Complex Clinical Outcomes During Morphine Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Met-enkephalin concentrations in striatum respond reciprocally to alterations in dopamine neurotransmission

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Neurologic and psychiatric manifestations in a family with a mutation in exon 2 of the guanosine triphosphate-cyclohydrolase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Autosomal dominant guanosine triphosphate cyclohydrolase I deficiency (Segawa disease).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Induction of total insensitivity to capsaicin and hypersensitivity to garlic extract in human by decreased expression of TRPV1.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Increased sensitivity to thermal pain and reduced subcutaneous lidocaine efficacy in redheads

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Biochemical basis for analgesic activity of morphine-6-glucuronide. I. Penetration of morphine-6-glucuronide in the brain of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Morphine-6-glucuronide: analgesic effects and receptor binding profile in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

COMT Val108/158Met genotype affects the mu-opioid receptor system in the human brain: evidence from ligand-binding, G-protein activation and preproenkephalin mRNA expression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Current evidence for a genetic modulation of the response to analgesics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Pharmacogenetics of cytochrome p4502D6: genetic background and clinical implication

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

In-vitro analysis of the contribution of CYP2D6.35 to ultra-rapid metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Codeine intoxication associated with ultrarapid CYP2D6 metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Apnea in a child after oral codeine: a genetic variant - an ultra-rapid metabolizer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor

21 January 2018

1 reference

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Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine [seecomments]

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Genetic polymorphisms in the ABCB1 gene and the effects of fentanyl in Koreans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Are mu-opioid receptor polymorphisms important for clinical opioid therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Current evidence for a modulation of nociception by human genetic polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

Novel mutation in the HSN2 gene in a Korean patient with hereditary sensory and autonomic neuropathy type 2

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.2.179

21 January 2018

Identifiers

DOI

10.2217/14622416.9.2.179

1 reference

18 August 2017

1 reference