New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes (Q37127104)

18 August 2017

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title

New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes (English)

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18 August 2017

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3

Moin A Saleem

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18 August 2017

Avril A Morrison

1

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PubMed ID

18385267

18 August 2017

Rebecca L Viney

series ordinal

2

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PubMed ID

18385267

18 August 2017

Michael R Ladomery

series ordinal

4

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18 August 2017

2 April 2008

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American Journal of Physiology - Renal Physiology

18 August 2017

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18 August 2017

295

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18 August 2017

1

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18 August 2017

F12-7

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Donor splice-site mutations in WT1 are responsible for Frasier syndrome

18 August 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Overlapping RNA and DNA binding domains of the wt1 tumor suppressor gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

The Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Germline intronic and exonic mutations in the Wilms' tumour gene (WT1) affecting urogenital development

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

WT1 and NPHS2 mutations in Korean children with steroid-resistant nephrotic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Genomic imprinting at the WT1 gene involves a novel coding transcript (AWT1) that shows deregulation in Wilms' tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Podocyte biology in human disease

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

The Wt1+/R394W mouse displays glomerulosclerosis and early-onset renal failure characteristic of human Denys-Drash syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

The genomic organization and expression of the WT1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Alternative splicing and genomic structure of the Wilms tumor gene WT1

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Regulation of vascular endothelial growth factor, VEGF, gene promoter by the tumor suppressor, WT1.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

The many facets of the Wilms' tumour gene, WT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Normal human glomerular cells in culture

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

The human sex-determining gene SRY is a direct target of WT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

WT1 gene mutations in three girls with nephrotic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Clinical impact of research on the podocyte slit diaphragm

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

The Wilms tumor suppressor Wt1 promotes cell adhesion through transcriptional activation of the alpha4integrin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/-KTS splice isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Multifunctional zinc finger proteins in development and disease

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Expression in Xenopus oocytes shows that WT1 binds transcripts in vivo, with a central role for zinc finger one.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Presence of WT1, the Wilm's tumor suppressor gene product, in nuclear poly(A)(+) ribonucleoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Nephropathy and defective spermatogenesis in mice transgenic for a single isoform of the Wilms' tumour suppressor protein, WT1-KTS, together with one disrupted Wt1 allele.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Molecular basis for modulation of biological function by alternate splicing of the Wilms' tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

A WT1 exon 1 mutation in a child diagnosed with Denys-Drash syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Transcriptional repression mediated by the WT1 Wilms tumor gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Current therapy for Wilms' tumor

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Mice lacking the 68-amino-acid, mammal-specific N-terminal extension of WT1 develop normally and are fertile

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Study on the interaction of bovine serum albumin with acid cyanine 5R and its application in analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

The post-transcriptional roles of WT1, a multifunctional zinc-finger protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

A mammal-specific exon of WT1 is not required for development or fertility

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

WT1 and glomerular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

WT1 regulates the expression of the major glomerular podocyte membrane protein Podocalyxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Murine Denys-Drash syndrome: evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Transcriptional regulation by WT1 in development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Impaired glomerular maturation and lack of VEGF165b in Denys-Drash syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Wilms' tumor: past, present and (possibly) future.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

The major podocyte protein nephrin is transcriptionally activated by the Wilms' tumor suppressor WT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

The dysregulated glomerular cell growth in Denys-Drash syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

WT1 and PAX-2 podocyte expression in Denys-Drash syndrome and isolated diffuse mesangial sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Characterization of RNA aptamer binding by the Wilms' tumor suppressor protein WT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

Infrequent mutation of theWT1 gene in 77 Wilms' tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00597.2007

10.1152/AJPRENAL.00597.2007

21 January 2018

Identifiers

DOI

1 reference

18 August 2017

1 reference

PubMed ID

18385267