Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2). (Q37139671)

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scientific article published on 07 August 2008

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English	Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2).	scientific article published on 07 August 2008

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scholarly article

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11 January 2020

Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2) (English)

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11 January 2020

multiple drug resistance

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Kim L.R. Brouwer

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11 January 2020

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Sonia R Miranda

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11 January 2020

Jin Kyung Lee

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11 January 2020

Zhiming Wen

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11 January 2020

Philip C Smith

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11 January 2020

Roy L Hawke

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11 January 2020

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7 August 2008

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11 January 2020

Drug Metabolism and Disposition

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11 January 2020

36

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11 January 2020

11

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11 January 2020

2219-2226

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11 January 2020

Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized Silymarin

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14 September 2017

The potential of flavonoids to influence drug metabolism and pharmacokinetics by local gastrointestinal mechanisms

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14 September 2017

Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat

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14 September 2017

Silymarin as a new hepatoprotective agent in experimental cholestasis: new possibilities for an ancient medication.

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14 September 2017

Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites

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14 September 2017

Silymarin treatment of viral hepatitis: a systematic review

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14 September 2017

Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).

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14 September 2017

The ABC transporters MDR1 and MRP2: multiple functions in disposition of xenobiotics and drug resistance

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14 September 2017

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

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14 September 2017

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

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14 September 2017

The isolated perfused rat liver: conceptual and practical considerations

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14 September 2017

The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential

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14 September 2017

Effect of flavonoids on MRP1-mediated transport in Panc-1 cells

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14 September 2017

Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment

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29 September 2017

Isolated perfused liver.

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29 September 2017

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27 June 2018

Pharmacokinetics of silybin in bile following administration of silipide and silymarin in cholecystectomy patients

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27 June 2018

The pharmacokinetics of silymarin is altered in patients with hepatitis C virus and nonalcoholic Fatty liver disease and correlates with plasma caspase-3/7 activity

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3 September 2018

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3 September 2018

Hepatobiliary excretion of silibinin in normal and liver cirrhotic rats

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3 September 2018

Silybin is metabolized by cytochrome P450 2C8 in vitro.

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3 September 2018

Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats.

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3 September 2018

Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids.

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3 September 2018

Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1.

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3 September 2018

Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport

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3 September 2018

Application of liquid chromatography-electrospray ionization-ion trap mass spectrometry to investigate the metabolism of silibinin in human liver microsomes

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3 September 2018

Effect of the flavonoids biochanin A and silymarin on the P-glycoprotein-mediated transport of digoxin and vinblastine in human intestinal Caco-2 cells

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3 September 2018

Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum).

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3 September 2018

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3 September 2018

A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients

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20 October 2018

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12 December 2020

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Study on dose-linearity of the pharmacokinetics of silibinin diastereomers using a new stereospecific assay

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12 December 2020

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Comparative bioavailability of Silipide, a new flavanolignan complex, in rats

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12 December 2020

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Comparative pharmacokinetics of silipide and silymarin in rats

1 reference

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12 December 2020

based on heuristic

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Plasma concentrations of free and conjugated silybin after oral intake of a silybin-phosphatidylcholine complex (silipide) in healthy volunteers

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12 December 2020

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Effect of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a human tumor necrosis factor alpha-converting enzyme inhibitor, on the disposition of methotrexate: a transport

1 reference

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12 December 2020

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Identifiers

10.1124/DMD.108.021790

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11 January 2020

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11 January 2020

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11 January 2020

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