A chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases. (Q37151025)

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6 March 2020

title

A chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases (English)

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6 March 2020

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ChEBI release 2020-05-28

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Haidan Liu

1

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Kangdong Liu

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6 March 2020

Chan-Mi Park

4

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N R Thimmegowda

5

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Jae-Hyuk Jang

6

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In-Ja Ryoo

7

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Long He

8

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Sun-Ok Kim

9

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Naomi Oi

10

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Ki Won Lee

11

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Nak-Kyun Soung

12

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Yifeng Yang

14

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6 March 2020

Xinmin Zhou

15

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Raymond L Erikson

16

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Jong-Seog Ahn

17

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Joonsung Hwang

18

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Kyoon Eon Kim

19

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Zigang Dong

20

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Bo-Yeon Kim

21

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language of work or name

English

0 references

publication date

25 July 2013

1 reference

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Journal of Biological Chemistry

6 March 2020

published in

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volume

288

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6 March 2020

issue

36

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6 March 2020

page(s)

25924-25937

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New directions in targeting protein kinases: focusing upon true allosteric and bivalent inhibitors

6 March 2020

cites work

1 reference

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(3-Chloroacetyl)-indole, a novel allosteric AKT inhibitor, suppresses colon cancer growth in vitro and in vivo.

6 September 2017

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Molecular targets of phytochemicals for cancer prevention

6 September 2017

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Discovery of a Potential Allosteric Ligand Binding Site in CDK2

6 September 2017

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7,3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase

6 September 2017

1 reference

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Molecular mechanisms of cardiovascular toxicity of targeted cancer therapeutics.

6 September 2017

1 reference

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A novel class of cyclin-dependent kinase inhibitors identified by molecular docking act through a unique mechanism

6 September 2017

1 reference

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The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity

6 September 2017

1 reference

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Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation

6 September 2017

1 reference

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The resveratrol analogue 3,5,3',4',5'-pentahydroxy-trans-stilbene inhibits cell transformation via MEK

6 September 2017

1 reference

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Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764797

Cyclin E and SV40 small T antigen cooperate to bypass quiescence and contribute to transformation by activating CDK2 in human fibroblasts

6 September 2017

1 reference

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Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine

6 September 2017

1 reference

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Fyn is a novel target of (-)-epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation

6 September 2017

1 reference

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CDK inhibitors in cancer therapy: what is next?

6 September 2017

1 reference

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Targeting human medulloblastoma: oncolytic virotherapy with myxoma virus is enhanced by rapamycin.

6 September 2017

1 reference

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Molecular and cellular targets

6 September 2017

1 reference

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Effects of MAP kinase inhibitors on epidermal growth factor-induced neoplastic transformation of human keratinocytes

6 September 2017

1 reference

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Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764797

ZINC--a free database of commercially available compounds for virtual screening

6 September 2017

1 reference

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Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

6 September 2017

1 reference

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Promiscuity rules? The dispensability of cyclin E and Cdk2

6 September 2017

1 reference

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Cdk2 knockout mice are viable

6 September 2017

1 reference

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A p53-dependent checkpoint pathway prevents rereplication

6 September 2017

1 reference

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Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence

6 September 2017

1 reference

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To cycle or not to cycle: a critical decision in cancer.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764797

Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms

6 September 2017

1 reference

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Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol.

6 September 2017

1 reference

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Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation

6 September 2017

1 reference

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The regulation of E2F by pRB-family proteins

6 September 2017

1 reference

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Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program

6 September 2017

1 reference

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Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation

6 September 2017

1 reference

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The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2

6 September 2017

1 reference

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Cyclin A expression is under negative transcriptional control during the cell cycle

6 September 2017

1 reference

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6 September 2017

1 reference

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Distinct roles for cyclin-dependent kinases in cell cycle control

6 September 2017

1 reference

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Principles of CDK regulation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764797

Dissociation of mitogenesis and late-stage promotion of tumor cell phenotype by phorbol esters: mitogen-resistant variants are sensitive to promotion

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764797

Design, synthesis and biological evaluation of chrysin long-chain derivatives as potential anticancer agents

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764797

A regulatory mechanism for RSK2 NH(2)-terminal kinase activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764797

E2Fs link the control of G1/S and G2/M transcription

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764797

Synthesis and anticancer effect of chrysin derivatives

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764797

Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764797

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764797

Chrysin and its phosphate ester inhibit cell proliferation and induce apoptosis in Hela cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764797

Mutual requirement of CDK4 and Myc in malignant transformation: evidence for cyclin D1/CDK4 and p16INK4A as upstream regulators of Myc.

27 June 2018

1 reference

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Synthesis of C(7) modified chrysin derivatives designing to inhibit beta-ketoacyl-acyl carrier protein synthase III (FabH) as antibiotics

27 June 2018

1 reference

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A general strategy for creating "inactive-conformation" abl inhibitors

3 September 2018

1 reference

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Epidermal growth factor-induced rapid retinoblastoma phosphorylation at Ser780 and Ser795 is mediated by ERK1/2 in small intestine epithelial cells

3 September 2018

1 reference

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Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764797

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764797

Proliferation of cancer cells despite CDK2 inhibition.

3 September 2018

1 reference

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CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis

3 September 2018

1 reference

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Glucuronidation versus oxidation of the flavonoid galangin by human liver microsomes and hepatocytes

3 September 2018

1 reference

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Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764797

Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23888052

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M113.464669

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23888052%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23888052%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

PubMed publication ID

23888052

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23888052%20AND%20SRC:MED&resulttype=core&format=json