The PPAR trio: regulators of myocardial energy metabolism in health and disease (Q37156948)

18 August 2017

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title

The PPAR trio: regulators of myocardial energy metabolism in health and disease (English)

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18 August 2017

Jose A Madrazo

1

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PubMed ID

18462747

18 August 2017

Daniel P Kelly

series ordinal

2

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18 August 2017

4 April 2008

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Journal of Molecular and Cellular Cardiology

18 August 2017

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18 August 2017

44

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18 August 2017

968-975

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18 August 2017

6

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Myocardial utilization of carbohydrate and lipids

18 August 2017

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Metabolic remodelling of the failing heart: the cardiac burn-out syndrome?

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Myocardial substrate metabolism: implications for diabetic cardiomyopathy

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Regulation of energy substrate metabolism in the diabetic heart

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Fatty acid metabolism is enhanced in type 2 diabetic hearts

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Inherited cardiomyopathies

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Regulation of muscle fiber type and running endurance by PPARdelta

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

PPAR gamma is required for placental, cardiac, and adipose tissue development

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Reciprocal responses to clofibrate in ketogenesis and triglyceride and cholesterol secretion in isolated rat liver

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Alterations in rat serum lipids and apolipoproteins following clofibrate treatment

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Peroxisome proliferator-activated receptors in inflammation control

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Peroxisome proliferator-activated receptors: nuclear control of metabolism

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated wi

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

PPAR-alpha activation required for decreased glucose uptake and increased susceptibility to injury during ischemia

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Decreased contractile and metabolic reserve in peroxisome proliferator-activated receptor-alpha-null hearts can be rescued by increasing glucose transport and utilization

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Peroxisome proliferator-activated receptor alpha and hypertensive heart disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Chronic activation of PPARalpha is detrimental to cardiac recovery after ischemia

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Streptozotocin-induced changes in cardiac gene expression in the absence of severe contractile dysfunction

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

CD36 Deficiency Rescues Lipotoxic Cardiomyopathy

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

CD36 expression contributes to age-induced cardiomyopathy in mice

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Metabolic control through the PGC-1 family of transcription coactivators

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Biological control through regulated transcriptional coactivators

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Transcriptional regulatory circuits controlling mitochondrial biogenesis and function

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Peroxisome proliferator-activated receptor delta (PPARdelta) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Metabolic plasticity and the promotion of cardiac protection in ischemia and ischemic preconditioning

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Treating ischemic heart disease by pharmacologically improving cardiac energy metabolism

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Cardiac peroxisome proliferator-activated receptor γ is essential in protecting cardiomyocytes from oxidative damage

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Activation of PPARgamma enhances myocardial glucose oxidation and improves contractile function in isolated working hearts of ZDF rats

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Beneficial effects of PPAR-gamma ligands in ischemia-reperfusion injury, inflammation and shock

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Cardioprotective effects of troglitazone in streptozotocin-induced diabetic rats

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Rosiglitazone, a peroxisome proliferator-activated receptor-gamma, inhibits the Jun NH(2)-terminal kinase/activating protein 1 pathway and protects the heart from ischemia/reperfusion injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Troglitazone improves recovery of left ventricular function after regional ischemia in pigs

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

In vivo myocardial protection from ischemia/reperfusion injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates myocardial ischemia/reperfusion injury in a rat model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Antioxidative, Antinitrative, and Vasculoprotective Effects of a Peroxisome Proliferator–Activated Receptor-γ Agonist in Hypercholesterolemia

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Anti-apoptotic effects of rosiglitazone in hypercholesterolemic rabbits subjected to myocardial ischemia and reperfusion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Down-regulation of acyl-CoA oxidase gene expression in heart of troglitazone-treated mice through a mechanism involving chicken ovalbumin upstream promoter transcription factor II.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Adaptation and maladaptation of the heart in diabetes: Part II: potential mechanisms

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Adaptation and maladaptation of the heart in diabetes: Part I: general concepts

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

The intrinsic circadian clock within the cardiomyocyte

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Circadian rhythms in myocardial metabolism and contractile function: influence of workload and oleate

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

The circadian clock within the cardiomyocyte is essential for responsiveness of the heart to fatty acids.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Diurnal variations in the responsiveness of cardiac and skeletal muscle to fatty acids

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

The circadian clock within the heart: potential influence on myocardial gene expression, metabolism, and function

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Intrinsic diurnal variations in cardiac metabolism and contractile function

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

Clock genes in the heart: characterization and attenuation with hypertrophy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.03.021

10.1016/J.YJMCC.2008.03.021

7 January 2021

Identifiers

DOI

1 reference

18 August 2017

1 reference

PubMed ID

18462747