Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator. (Q37158103)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18794844%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

title

Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator (English)

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14 January 2020

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3

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14 January 2020

author name string

Ying Feng

series ordinal

1

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14 January 2020

Mo Chen

series ordinal

2

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14 January 2020

language of work or name

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14 September 2008

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Nature Structural & Molecular Biology

14 January 2020

published in

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14 January 2020

volume

15

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14 January 2020

issue

10

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14 January 2020

page(s)

1040-1048

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https://scigraph.springernature.com/pub.10.1038/nsmb.1485

14 January 2020

exact match

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cites work

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Multiple properties of the splicing repressor SRp38 distinguish it from typical SR proteins.

6 September 2017

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The SR protein SRp38 represses splicing in M phase cells

6 September 2017

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SR proteins Asf/SF2 and 9G8 interact to activate enhancer-dependent intron D splicing of bovine growth hormone pre-mRNA in vitro

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Cloning and characterization of two neural-salient serine/arginine-rich (NSSR) proteins involved in the regulation of alternative splicing in neurones.

6 September 2017

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The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing

6 September 2017

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The SRm160/300 splicing coactivator is required for exon-enhancer function

6 September 2017

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Enhancer elements activate the weak 3' splice site of alpha-tropomyosin exon 2.

6 September 2017

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Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2.

6 September 2017

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Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing

6 September 2017

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Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer

6 September 2017

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Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene

6 September 2017

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6 September 2017

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The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing

6 September 2017

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Polypurine sequences within a downstream exon function as a splicing enhancer

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities

6 September 2017

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Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity

6 September 2017

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Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

6 September 2017

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A complex signaling pathway regulates SRp38 phosphorylation and pre-mRNA splicing in response to heat shock

6 September 2017

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Arginine/serine-rich domains of SR proteins can function as activators of pre-mRNA splicing

14 September 2017

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Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways

27 June 2018

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ASF/SF2 and SC35 regulate the glutamate receptor subunit 2 alternative flip/flop splicing

27 June 2018

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Tra2betal regulates P19 neuronal differentiation and the splicing of FGF-2R and GluR-B minigenes

3 September 2018

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Arginine-serine-rich domains bound at splicing enhancers contact the branchpoint to promote prespliceosome assembly

3 September 2018

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Distinct factor requirements for exonic splicing enhancer function and binding of U2AF to the polypyrimidine tract.

3 September 2018

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Functions of SR and Tra2 proteins in pre-mRNA splicing regulation.

3 September 2018

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Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing.

3 September 2018

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The Sex-lethal amino terminus mediates cooperative interactions in RNA binding and is essential for splicing regulation.

3 September 2018

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SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome

3 September 2018

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A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly

3 September 2018

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Crossref

https://api.crossref.org/works/10.1038%2FNSMB.1485

Modification of a PCR-based site-directed mutagenesis method

31 March 2020

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Crossref

https://api.crossref.org/works/10.1038%2FNSMB.1485

31 March 2020

Identifiers

DOI

10.1038/NSMB.1485

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18794844%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18794844%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

PubMed publication ID

18794844

1 reference