The RCAN carboxyl end mediates calcineurin docking-dependent inhibition via a site that dictates binding to substrates and regulators. (Q37158993)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19332797%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

title

The RCAN carboxyl end mediates calcineurin docking-dependent inhibition via a site that dictates binding to substrates and regulators (English)

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25 January 2020

2

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25 January 2020

Antonio Andres Rodríguez

3

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25 January 2020

Juan Miguel Redondo

8

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25 January 2020

Susana de la Luna

9

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25 January 2020

author name string

Sara Martínez-Martínez

1

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25 January 2020

Alicia Raya

4

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25 January 2020

Eulàlia Salichs

5

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25 January 2020

Felipe Were

6

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25 January 2020

María Dolores López-Maderuelo

7

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25 January 2020

language of work or name

English

0 references

publication date

30 March 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19332797%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

25 January 2020

number of pages

6

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based on heuristic

inferred from page(s)

published in

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25 January 2020

volume

106

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25 January 2020

issue

15

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25 January 2020

page(s)

6117-6122

1 reference

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Structural basis for regulation of protein phosphatase 1 by inhibitor-2

25 January 2020

cites work

1 reference

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Structure of the Calcineurin-NFAT Complex: Defining a T Cell Activation Switch Using Solution NMR and Crystal Coordinates

6 September 2017

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Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction

6 September 2017

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RCAN3, a novel calcineurin inhibitor that down-regulates NFAT-dependent cytokine gene expression

6 September 2017

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6 September 2017

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Docking interactions in protein kinase and phosphatase networks

6 September 2017

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Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo

6 September 2017

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Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo

6 September 2017

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The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT.

6 September 2017

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Structural basis of protein phosphatase 1 regulation

6 September 2017

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Inhibitors of the calcineurin/NFAT pathway.

6 September 2017

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GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs

6 September 2017

1 reference

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Transcriptional regulation by calcium, calcineurin, and NFAT

6 September 2017

1 reference

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Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy

6 September 2017

1 reference

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Mapping the protein phosphatase-2B anchoring site on AKAP79. Binding and inhibition of phosphatase activity are mediated by residues 315-360.

6 September 2017

1 reference

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Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors

6 September 2017

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Multiple domains of MCIP1 contribute to inhibition of calcineurin activity

6 September 2017

1 reference

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Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans

6 September 2017

1 reference

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A conserved family of calcineurin regulators.

6 September 2017

1 reference

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DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways

6 September 2017

1 reference

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A second calcineurin binding site on the NFAT regulatory domain

6 September 2017

1 reference

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A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling

6 September 2017

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Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.

6 September 2017

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Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT

6 September 2017

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Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes

6 September 2017

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Regulation of the calmodulin-stimulated protein phosphatase, calcineurin

6 September 2017

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Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1

6 September 2017

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Functional characterization of the calcipressin 1 motif that suppresses calcineurin-mediated NFAT-dependent cytokine gene expression in human T cells

6 September 2017

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14 September 2017

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Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth

27 June 2018

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The Down syndrome critical region protein RCAN1 regulates long-term potentiation and memory via inhibition of phosphatase signaling

3 September 2018

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Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.

3 September 2018

1 reference

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Structural delineation of the calcineurin-NFAT interaction and its parallels to PP1 targeting interactions

3 September 2018

1 reference

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The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19332797

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Blockade of NFAT activation by the second calcineurin binding site

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19332797

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0812544106

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19332797%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

0 references

1 reference

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25 January 2020

PubMed publication ID

19332797

1 reference