A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity. (Q37162862)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18988862%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

title

A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity (English)

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25 December 2019

1

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25 December 2019

author name string

Laiman Xiang

2

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25 December 2019

Oleg Chertov

3

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25 December 2019

Inger Margulies

4

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25 December 2019

Robert J Kreitman

5

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25 December 2019

David J FitzGerald

6

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25 December 2019

Ira Pastan

7

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25 December 2019

language of work or name

English

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publication date

6 November 2008

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25 December 2019

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25 December 2019

volume

113

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25 December 2019

issue

16

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25 December 2019

page(s)

3792-3800

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An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes

25 December 2019

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6 September 2017

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FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins

6 September 2017

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6 September 2017

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6 September 2017

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LRP 1 B functions as a receptor for Pseudomonas exotoxin

6 September 2017

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DNA profiling and cytogenetic analysis of cell line WSU-CLL reveal cross-contamination with cell line REH (pre B-ALL)

6 September 2017

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Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display.

6 September 2017

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Refined crystallographic structure of Pseudomonas aeruginosa exotoxin A and its implications for the molecular mechanism of toxicity

6 September 2017

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Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia

6 September 2017

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Cathepsin S required for normal MHC class II peptide loading and germinal center development

6 September 2017

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Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation

6 September 2017

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Isolation of a high-affinity stable single-chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity

6 September 2017

1 reference

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Improved antitumor activity of a recombinant anti-Lewis(y) immunotoxin not requiring proteolytic activation

6 September 2017

1 reference

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Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution

6 September 2017

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Biochemical and immunochemical studies of proteolytic fragments of exotoxin A from Pseudomonas aeruginosa

6 September 2017

1 reference

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Substitution of foreign protein sequences into a chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin

6 September 2017

1 reference

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Acid-triggered membrane insertion of Pseudomonas exotoxin A involves an original mechanism based on pH-regulated tryptophan exposure

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670794

HA22 (R490A) is a recombinant immunotoxin with increased antitumor activity without an increase in animal toxicity.

14 September 2017

1 reference

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Recombinant immunotoxins in the treatment of cancer

14 September 2017

1 reference

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Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies

14 September 2017

1 reference

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Reduction of furin-nicked Pseudomonas exotoxin A: an unfolding story

14 September 2017

1 reference

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A deletion within the translocation domain of Pseudomonas exotoxin A enhances translocation efficiency and cytotoxicity concomitantly.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670794

An early step in Pseudomonas exotoxin action is removal of the terminal lysine residue, which allows binding to the KDEL receptor

28 September 2017

1 reference

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28 September 2017

1 reference

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Cleavage of pseudomonas exotoxin and diphtheria toxin by a furin-like enzyme prepared from beef liver

28 September 2017

1 reference

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Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli.

29 September 2017

1 reference

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Domain II mutants of Pseudomonas exotoxin deficient in translocation

27 June 2018

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Functional analysis of domains II, Ib, and III of Pseudomonas exotoxin.

27 June 2018

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Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol

27 June 2018

1 reference

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Translocation mediated by domain II of Pseudomonas exotoxin A: transport of barnase into the cytosol

27 June 2018

1 reference

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Glomerular permselectivity: barrier function based on discrimination of molecular size and charge

27 June 2018

1 reference

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Specific role for cathepsin S in the generation of antigenic peptides in vivo

27 June 2018

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Lowering the isoelectric point of the Fv portion of recombinant immunotoxins leads to decreased nonspecific animal toxicity without affecting antitumor activity

3 September 2018

1 reference

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Lysosomal cathepsin B plays an important role in antigen processing, while cathepsin D is involved in degradation of the invariant chain inovalbumin-immunized mice.

3 September 2018

1 reference

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Immunotoxin therapy of cancer

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670794

Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) toward fresh malignant cells from patients with B-cell leukemias

20 October 2018

1 reference

12 December 2020

Recombinant immunotoxins containing anti-Tac(Fv) and derivatives of Pseudomonas exotoxin produce complete regression in mice of an interleukin-2 receptor-expressing human carcinoma

1 reference

12 December 2020

Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment

1 reference

12 December 2020

Analysis of sequences required for the cytotoxic action of a chimeric toxin composed of Pseudomonas exotoxin and transforming growth factor alpha

1 reference

12 December 2020

Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice

1 reference

12 December 2020

Complete regression of human B-cell lymphoma xenografts in mice treated with recombinant anti-CD22 immunotoxin RFB4(dsFv)-PE38 at doses tolerated by cynomolgus monkeys

1 reference

12 December 2020

Phase I trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with B-cell malignancies

1 reference

12 December 2020

Phase I study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers

1 reference

12 December 2020

Inhibition of TNF-alpha produced by Kupffer cells protects against the nonspecific liver toxicity of immunotoxin anti-Tac(Fv)-PE38, LMB-2

1 reference

12 December 2020

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A

1 reference

12 December 2020

Reduction of the nonspecific animal toxicity of anti-Tac(Fv)-PE38 by mutations in the framework regions of the Fv which lower the isoelectric point

1 reference

12 December 2020

10.1182/BLOOD-2008-08-173195

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18988862%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18988862%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

PubMed publication ID

18988862

1 reference