High glucose suppresses epidermal growth factor receptor/phosphatidylinositol 3-kinase/Akt signaling pathway and attenuates corneal epithelial wound healing (Q37163511)

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scientific article published on 02 February 2009

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English	High glucose suppresses epidermal growth factor receptor/phosphatidylinositol 3-kinase/Akt signaling pathway and attenuates corneal epithelial wound healing	scientific article published on 02 February 2009

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scholarly article

1 reference

Europe PubMed Central

18 August 2017

High glucose suppresses epidermal growth factor receptor/phosphatidylinositol 3-kinase/Akt signaling pathway and attenuates corneal epithelial wound healing (English)

1 reference

Europe PubMed Central

18 August 2017

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1 reference

based on heuristic

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author name string

Ke-Ping Xu

1

1 reference

Europe PubMed Central

18 August 2017

Yanfeng Li

2

1 reference

Europe PubMed Central

18 August 2017

Alexander V Ljubimov

3

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Europe PubMed Central

18 August 2017

Fu-Shin X Yu

4

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Europe PubMed Central

18 August 2017

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publication date

2 February 2009

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Europe PubMed Central

18 August 2017

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Europe PubMed Central

18 August 2017

58

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Europe PubMed Central

18 August 2017

1077-1085

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Europe PubMed Central

18 August 2017

5

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Europe PubMed Central

18 August 2017

copyright license

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

27 August 2021

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April 2022 Public Data File from Crossref

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The role of corneal crystallins in the cellular defense mechanisms against oxidative stress

1 reference

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6 September 2017

The epidermal growth factor receptor: from development to tumorigenesis

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6 September 2017

Deviated mechanism of wound healing in diabetic corneas

1 reference

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6 September 2017

AKT/PKB signaling: navigating downstream

1 reference

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6 September 2017

Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice

1 reference

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6 September 2017

Lysophosphatidic acid promoting corneal epithelial wound healing by transactivation of epidermal growth factor receptor

1 reference

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6 September 2017

ALDH3A1: a corneal crystallin with diverse functions

1 reference

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6 September 2017

Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress.

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6 September 2017

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1 reference

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6 September 2017

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6 September 2017

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6 September 2017

Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications

1 reference

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6 September 2017

Role of ErbB2 in Corneal Epithelial Wound Healing

1 reference

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6 September 2017

Wound-induced HB-EGF ectodomain shedding and EGFR activation in corneal epithelial cells

1 reference

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6 September 2017

Human diabetic corneas preserve wound healing, basement membrane, integrin and MMP-10 differences from normal corneas in organ culture.

1 reference

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6 September 2017

Diabetic keratopathy.

1 reference

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6 September 2017

Estrone Modulates the EGF Receptor in the Liver of db/db Mouse

1 reference

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6 September 2017

Epidermal growth factor receptor inhibition attenuates early kidney enlargement in experimental diabetes

1 reference

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14 September 2017

Prevention and treatment of the complications of diabetes mellitus

1 reference

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14 September 2017

The effect of elevated extracellular glucose on migration, adhesion and proliferation of SV40 transformed human corneal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

28 September 2017

An SV40-immortalized human corneal epithelial cell line and its characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

29 September 2017

Delayed wound closure and phenotypic changes in corneal epithelium of the spontaneously diabetic Goto-Kakizaki rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

27 June 2018

Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

27 June 2018

Non-enzymatic glycation in corneas from normal and diabetic donors and its effects on epithelial cell attachment in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

27 June 2018

Human corneal epithelial basement membrane and integrin alterations in diabetes and diabetic retinopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

27 June 2018

Heterogeneous expression of transketolase in ocular tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

27 June 2018

Transketolase is a major protein in the mouse cornea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

27 June 2018

Corneal epithelial changes in diabetic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

27 June 2018

Altered epithelial-basement membrane interactions in diabetic corneas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

27 June 2018

Developmental changes in extracellular matrix messenger RNAs in the mouse placenta during the second half of pregnancy: possible factors involved in the regulation of placental extracellular matrix expression.

1 reference

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3 September 2018

Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner

1 reference

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3 September 2018

High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

3 September 2018

Controlled-release of epidermal growth factor from cationized gelatin hydrogel enhances corneal epithelial wound healing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

3 September 2018

Insulin treatment ameliorates impaired corneal reepithelialization in diabetic rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

3 September 2018

Transmission electron microscopy and autofluorescence findings in the cornea of diabetic rats treated with aminoguanidine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

3 September 2018

Reduced expression of laminin-5 in corneal epithelial cells under high glucose condition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

3 September 2018

High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway

1 reference

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3 September 2018

Prevention of diabetic keratopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

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3 September 2018

Prolonged exposure to high glucose impaired cellular behavior of normal human corneal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

3 September 2018

Promotion of corneal epithelial wound healing in diabetic rats by the combination of a substance P-derived peptide (FGLM-NH2) and insulin-like growth factor-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

3 September 2018

Naltrexone, an opioid antagonist, facilitates reepithelialization of the cornea in diabetic rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

3 September 2018

Region-specific pathophysiological alterations occurring in calf lenses in vitro during hyperglycemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

3 September 2018

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671049

3 September 2018

Blinking and superficial punctate keratopathy in patients with diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt/FoxO signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autologous serum for the treatment of corneal epithelial abrasions in diabetic patients undergoing vitrectomy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is autologous serum a tonic for the ailing corneal epithelium?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maternal diabetes in vivo and high glucose concentration in vitro increases apoptosis in rat embryos

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corneal diabetic neuropathy: a confocal microscopy study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrastructural changes in corneas of diabetic patients: an electron-microscopy study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix metalloproteinase activity is enhanced during corneal wound repair in high glucose condition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corneal advanced glycation end products increase in patients with proliferative diabetic retinopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corneal epithelial basement membrane changes in diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of EGF on the corneal wound healing of alloxan diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ocular manifestations of diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corneal epithelial fragility in diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple organ culture model for assessing the effects of growth factors on corneal re-epithelialization

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acceleration of corneal wound healing in diabetic rats by the antioxidant trolox

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corneal re-epithelialization in galactosemic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffuse punctate keratitis in a patient treated with cetuximab as monotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corneal Sensitivity Is Reduced and Relates to the Severity of Neuropathy in Patients With Diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SHIP2 controls PtdIns(3,4,5)P(3) levels and PKB activity in response to oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of topical insulin to normalize corneal epithelial healing in diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19188434

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2337/DB08-0997

1 reference

Europe PubMed Central

18 August 2017

1 reference

Europe PubMed Central

18 August 2017

1 reference

Europe PubMed Central

18 August 2017

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