Plasma pharmacokinetics and oral bioavailability of 3,4,5,6-tetrahydrouridine, a cytidine deaminase inhibitor, in mice (Q37180971)

18 August 2017

Plasma pharmacokinetics and oral bioavailability of 3,4,5,6-tetrahydrouridine, a cytidine deaminase inhibitor, in mice (English)

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18 August 2017

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Jan H Beumer

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18 August 2017

Julie L Eiseman

2

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18 August 2017

Robert A Parise

3

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18 August 2017

Jeffry A Florian

4

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18 August 2017

Erin Joseph

5

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18 August 2017

David Z D'Argenio

6

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18 August 2017

Robert S Parker

7

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18 August 2017

Brittany Kay

8

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18 August 2017

Joseph M Covey

9

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18 August 2017

Merrill J Egorin

10

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18 August 2017

15 November 2007

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Cancer Chemotherapy and Pharmacology

18 August 2017

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18 August 2017

62

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18 August 2017

3

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18 August 2017

457-464

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https://scigraph.springernature.com/pub.10.1007/s00280-007-0625-2

18 August 2017

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cites work

Inhibitors of DNA methylation: beyond myelodysplastic syndromes

1 reference

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Tetrahydrouridine specifically facilitates deoxycytidine incorporation into herpes simplex virus DNA

6 September 2017

1 reference

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Phase I evaluation of tetrahydrouridine combined with cytosine arabinoside

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677692

Enhancement by tetrahydrouridine (NSC-112907) of the oral activity of 5-azacytidine (NSC-102816) in L1210 leukemic mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677692

New antimetabolites in cancer chemotherapy and their clinical impact

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677692

Metabolism of 1-beta-D-arabinofuranosylcytosine in human leukemic cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677692

Quantitative determination of the cytidine deaminase inhibitor tetrahydrouridine (THU) in mouse plasma by liquid chromatography/electrospray ionization tandem mass spectrometry

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677692

Distribution of [3H]cytosine arabinoside and its products in mice, dogs, and monkeys and effect of tetrahydrouridine

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677692

Drug resistance to 5-aza-2'-deoxycytidine, 2',2'-difluorodeoxycytidine, and cytosine arabinoside conferred by retroviral-mediated transfer of human cytidine deaminase cDNA into murine cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677692

Acute cerebellar toxicity after high-dose cytarabine associated with CNS accumulation of its metabolite, uracil arabinoside

26 June 2018

1 reference

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Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677692

Cytidine deaminase from Escherichia coli. Purification, properties and inhibition by the potential transition state analog 3,4,5,6-tetrahydrouridine

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677692

Neurotoxicity associated with systemic high-dose cytosine arabinoside

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677692

Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies.

26 June 2018

1 reference

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Effect of tetrahydrouridine and deoxytetrahydrouridine on the interaction between 2'-deoxycytidine and 1-beta-D-arabinofuranosylcytosine in human leukemia cells

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677692

Distribution of tetrahydrouridine in experimental animals

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677692

Analytical and pharmacokinetic studies with 5-chloro-2'-deoxycytidine

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677692

Preclinical toxicologic evaluation of tetrahydrouridine (NSC-112907) in beagle dogs and rhesus monkeys

3 September 2018

1 reference

12 December 2020

Tetrahydrouridine: Physiologic disposition and effect upon deamination of cytosine arabinoside in man

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12 December 2020

Analysis of cytidine deaminase and tetrahydrouridine interaction by use of ligand techniques

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12 December 2020

Clinical Pharmacology of Tetrahydrouridine

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12 December 2020

Effects of tetrahydrouridine on the uptake and metabolism of 1-beta-D-arabinofuranosylcytosine in human normal and leukemic cells

1 reference

12 December 2020

Comparison of the bioavailability of uridine in mice after either oral or parenteral administration

1 reference

12 December 2020

Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites

1 reference

12 December 2020

Effect of tetrahydrouridine on the clinical pharmacology of 1-beta-D-arabinofuranosylcytosine when both drugs are coinfused over three hours

1 reference

12 December 2020

Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase

1 reference

12 December 2020

Metabolism and disposition of gemcitabine, and oncolytic deoxycytidine analog, in mice, rats, and dogs

1 reference

12 December 2020

Effect of Tetrahydrouridine on Metabolism and Transport of 1-β-<i>D</i>-Arabinofuranosylcytosine in Human Cells

1 reference

12 December 2020

Therapy of refractory/relapsed acute myeloid leukemia and blast crisis of chronic myeloid leukemia with the combination of cytosine arabinoside, tetrahydrouridine, and carboplatin

1 reference

12 December 2020

Five-chlorodeoxycytidine and biomodulators of its metabolism result in fifty to eighty percent cures of advanced EMT-6 tumors when used with fractionated radiation

1 reference

12 December 2020

Opiate effects on 5-fluorouracil disposition in mice

1 reference

12 December 2020

Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine in mice

1 reference

12 December 2020

Studies of the enzymatic deamination of cytosine arabinoside. I. Enzyme distribution and species specificity

1 reference

12 December 2020

Enhancement by tetrahydrouridine of 1-beta-D-arabinofuranosylcytosine (cytarabine) oral activity in L1210 leukemic mice

1 reference

12 December 2020

Distribution of kinase and deaminase of 1-beta-D-arabinofuranosylcytosine in tissues of man and mouse

1 reference

12 December 2020

Inhibition of deamination of 14C-cytosine arabinoside (NSC-63878): a useful biologic assay for tetrahydrouridine (NSC-112907)

1 reference

12 December 2020

Influence of tetrahydrouridine on the phosphorylation of 1-beta-D-arabinofuranosyl-cytosine (ara-C) by enzymes from solid tumors in vitro

1 reference

12 December 2020

10.1007/S00280-007-0625-2

Identifiers

DOI

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18 August 2017

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18 August 2017

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