Pharmacokinetics of efavirenz when co-administered with rifampin in TB/HIV co-infected patients: Pharmacogenetic effect of CYP2B6 variation (Q37186259)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18728241%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

title

Pharmacokinetics of efavirenz when co-administered with rifampin in TB/HIV co-infected patients: pharmacogenetic effect of CYP2B6 variation (English)

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12 January 2020

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Periconceptional exposure to efavirenz and neural tube defects

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Genetic Polymorphisms

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7

Boima, V.

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David J Greenblatt

Greenblatt, D.J.

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12 January 2020

Michael H Court

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Court, M.H.

Michael H Court

11

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Awewura Kwara

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Margaret Lartey

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author name string

Kwamena W Sagoe

3

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Fafa Xexemeku

4

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Ernest Kenu

5

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Joseph Oliver-Commey

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Augustine Sagoe

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Isaac Boamah

9

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language of work or name

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1 September 2008

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The Journal of Clinical Pharmacology

12 January 2020

2008

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published in

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volume

48

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issue

9

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page(s)

1032-1040

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http://ugspace.ug.edu.gh/handle/123456789/29186

12 January 2020

exact match

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cites work

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Aberrant splicing caused by single nucleotide polymorphism c.516G>T [Q172H], a marker of CYP2B6*6, is responsible for decreased expression and activity of CYP2B6 in liver

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High prevalence of the CYP2B6 516G-->T(*6) variant and effect on the population pharmacokinetics of efavirenz in HIV/AIDS outpatients in Zimbabwe

14 September 2017

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Administration of efavirenz (600 mg/day) with rifampicin results in highly variable levels but excellent clinical outcomes in patients treated for tuberculosis and HIV.

3 September 2018

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Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism of the HIV drug efavirenz

3 September 2018

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Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz

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3 September 2018

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3 September 2018

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3 September 2018

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3 September 2018

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12 December 2020

Updated guidelines for the use of rifabutin or rifampin for the treatment and prevention of tuberculosis among HIV-infected patients taking protease inhibitors or nonnucleoside reverse transcriptase inhibitors

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12 December 2020

Simple and rapid liquid chromatography method for determination of efavirenz in plasma

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12 December 2020

Survival rate and risk factors of mortality among HIV/tuberculosis-coinfected patients with and without antiretroviral therapy

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12 December 2020

Identifiers

DOI

10.1177/0091270008321790

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12 January 2020

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12 January 2020

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