Diabetes: 1 and 2, or one and the same? Progress with the accelerator hypothesis (Q37186774)

18 August 2017

1 reference

title

Diabetes: 1 and 2, or one and the same? Progress with the accelerator hypothesis (English)

1 reference

18 August 2017

Terence J Wilkin

1

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18 August 2017

1 June 2008

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18 August 2017

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18 August 2017

9

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18 August 2017

23-32

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18 August 2017

3 Pt 2

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The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes

18 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Testing the accelerator hypothesis: the relationship between body mass and age at diagnosis of type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Increasing body weight predicts the earlier onset of insulin-dependant diabetes in childhood: testing the 'accelerator hypothesis' (2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

The 'accelerator hypothesis': relationship between weight, height, body mass index and age at diagnosis in a large cohort of 9,248 German and Austrian children with type 1 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Higher body weight is associated with earlier onset of Type 1 diabetes in children: confirming the 'Accelerator Hypothesis'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Testing the accelerator hypothesis: body size, beta-cell function, and age at onset of type 1 (autoimmune) diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Obesity, Insulin Resistance, β-Cell Autoimmunity, and the Changing Clinical Epidemiology of Childhood Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Type 1 diabetes: recent developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Major increase in Type 1 diabetes: no support for the Accelerator Hypothesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

HL-A antigens and diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Five stages of evolving beta-cell dysfunction during progression to diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

The rise of childhood type 1 diabetes in the 20th century.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Coexistence of type 1 and type 2 diabetes mellitus: "double" diabetes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Clinical review: Type 1 diabetes and latent autoimmune diabetes in adults: one end of the rainbow

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Can we slow the rising incidence of childhood-onset autoimmune diabetes? The overload hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Clinical and pathogenic significance of pancreatic-islet-cell antibodies in diabetics treated with oral hypoglycaemic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Worldwide increase in incidence of Type I diabetes--the analysis of the data on published incidence trends

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Letter: Weight gain in infancy and subsequent development of diabetes mellitus in childhood

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

A high weight gain early in life is associated with an increased risk of type 1 (insulin-dependent) diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Infant feeding, early weight gain, and risk of type 1 diabetes. Childhood Diabetes in Finland (DiMe) Study Group.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes--indication of an increased environmental pressure?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

The role of insulin resistance in the natural history of type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Insulin resistance in type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Insulin resistance is a risk factor for progression to type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

No evidence for genetically determined alteration in insulin secretion or sensitivity predisposing to type 1 diabetes: a study of identical twins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Normal weight promotes remission and low number of islet antibodies prolong the duration of remission in Type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

High frequency of abnormal glucose tolerance in DQA1*0102/DQB1*0602 relatives identified as part of the Diabetes Prevention Trial--Type 1 Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Diabetic autoimmune markers in children and adolescents with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Autoimmunity to islet proteins in children diagnosed with new-onset diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Braking the accelerator hypothesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Pre-type 1 diabetes dysmetabolism: maximal sensitivity achieved with both oral and intravenous glucose tolerance testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Testing the accelerator hypothesis: body size, beta-cell function, and age at onset of type 1 (autoimmune) diabetes: response to Dabelea et al.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Analysis of the obesity gene FTO in 14,803 type 1 diabetes cases and controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

An Association of Autoantibody Status and Serum Cytokine Levels in Type 1 Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

The relative contributions of birth weight, weight change, and current weight to insulin resistance in contemporary 5-year-olds: the EarlyBird Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Islet autoantibodies in clinically diagnosed type 2 diabetes: prevalence and relationship with metabolic control (UKPDS 70).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

Future intervention trials in type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1399-5448.2007.00343.X

10.1111/J.1399-5448.2007.00343.X

21 January 2018

Identifiers

DOI

1 reference

18 August 2017

1 reference

PubMed ID

18540866