Poststroke Induction of α-Synuclein Mediates Ischemic Brain Damage (Q37196992)

18 August 2017

Poststroke Induction of α-Synuclein Mediates Ischemic Brain Damage (English)

1 reference

18 August 2017

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1

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9 June 2020

Kirsten Lyons

4

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9 June 2020

Robert J Dempsey

5

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9 June 2020

author name string

Suresh L Mehta

2

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9 June 2020

Balarama Kaimal

3

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9 June 2020

Raghu Vemuganti

6

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9 June 2020

language of work or name

English

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publication date

1 June 2016

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18 August 2017

Journal of Neuroscience

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9 June 2020

volume

36

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9 June 2020

page(s)

7055-7065

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9 June 2020

issue

26

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describes a project that uses

9 June 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4994709/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Long Noncoding RNA FosDT Promotes Ischemic Brain Injury by Interacting with REST-Associated Chromatin-Modifying Proteins

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Resveratrol neuroprotection in stroke and traumatic CNS injury

6 September 2017

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Seeking a mechanism for the toxicity of oligomeric α-synuclein

6 September 2017

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Crosstalk Between Endoplasmic Reticulum Stress, Oxidative Stress, and Autophagy: Potential Therapeutic Targets for Acute CNS Injuries

6 September 2017

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Effect of sex and age interactions on functional outcome after stroke

6 September 2017

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Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction.

6 September 2017

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Protein phosphorylation in neurodegeneration: friend or foe?

6 September 2017

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The role of oxidative stress in Parkinson's disease

6 September 2017

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Alpha-synuclein post-translational modifications as potential biomarkers for Parkinson disease and other synucleinopathies

6 September 2017

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The Parkinson's disease-associated gene PINK1 protects neurons from ischemic damage by decreasing mitochondrial translocation of the fission promoter Drp1.

6 September 2017

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MicroRNA miR-29c down-regulation leading to de-repression of its target DNA methyltransferase 3a promotes ischemic brain damage

6 September 2017

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In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells

6 September 2017

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The many faces of α-synuclein: from structure and toxicity to therapeutic target

6 September 2017

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An extracellular mechanism that can explain the neurotoxic effects of α-synuclein aggregates in the brain

6 September 2017

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Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.

6 September 2017

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Extracellular signal-regulated kinase is involved in alpha-synuclein-induced mitochondrial dynamic disorders by regulating dynamin-like protein 1.

6 September 2017

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Inhibition of Drp1 provides neuroprotection in vitro and in vivo.

6 September 2017

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Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes.

6 September 2017

1 reference

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Increased cerebral protein ISGylation after focal ischemia is neuroprotective

6 September 2017

1 reference

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α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

6 September 2017

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Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model

6 September 2017

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In vivo demonstration that alpha-synuclein oligomers are toxic

6 September 2017

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Characterization of kinases involved in the phosphorylation of aggregated α-synuclein

6 September 2017

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Alpha-synuclein aggregation induced by brief ischemia negatively impacts neuronal survival in vivo: a study in [A30P]alpha-synuclein transgenic mouse

6 September 2017

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α-Synuclein impairs macroautophagy: implications for Parkinson's disease.

6 September 2017

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Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies

6 September 2017

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Functional assessments in the rodent stroke model

6 September 2017

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Autophagy and protein aggregation after brain ischemia

6 September 2017

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Phosphorylation of synucleins by members of the Polo-like kinase family

6 September 2017

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The emerging role of autophagy in Parkinson's disease

6 September 2017

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Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system

6 September 2017

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The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease

6 September 2017

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Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression

6 September 2017

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Mechanisms of neuronal death in synucleinopathy

6 September 2017

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Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery

6 September 2017

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Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

6 September 2017

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Evidence for stroke-induced neurogenesis in the human brain

6 September 2017

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Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons.

6 September 2017

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Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

6 September 2017

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Parkinson's disease: mechanisms and models

6 September 2017

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Down-regulation of parkin protein in transient focal cerebral ischemia: A link between stroke and degenerative disease?

6 September 2017

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alpha-Synuclein is phosphorylated in synucleinopathy lesions

6 September 2017

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Proteinase K-resistant alpha-synuclein is deposited in presynapses in human Lewy body disease and A53T alpha-synuclein transgenic mice

6 September 2017

1 reference

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Partial inhibition of Cdk1 in G 2 phase overrides the SAC and decouples mitotic events.

14 September 2017

1 reference

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Effect of focal ischemia on long noncoding RNAs

14 September 2017

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Potential role of α-synuclein in neurodegeneration: studies in a rat animal model

26 June 2018

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Transient focal ischemia induces extensive temporal changes in rat cerebral microRNAome

26 June 2018

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Influence of Amyloid-β on Cognitive Decline After Stroke/Transient Ischemic Attack: Three-Year Longitudinal Study.

26 June 2018

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Serum Aβ is predictive for short-term neurological deficits after acute ischemic stroke.

3 September 2018

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α-Synuclein A30P decreases neurodegeneration and increases synaptic vesicle release probability in CSPα-null mice

3 September 2018

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Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease.

3 September 2018

1 reference

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Superiority of PLK-2 as α-synuclein phosphorylating agent relies on unique specificity determinants.

3 September 2018

1 reference

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Altered expression of PIWI RNA in the rat brain after transient focal ischemia

3 September 2018

1 reference

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Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein.

3 September 2018

1 reference

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Different species of alpha-synuclein oligomers induce calcium influx and seeding.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4994709

Monocyte chemoattractant protein-1 plays a critical role in neuroblast migration after focal cerebral ischemia.

3 September 2018

1 reference

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JAK2 and STAT3 activation contributes to neuronal damage following transient focal cerebral ischemia.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4994709

Nuclear localization of alpha-synuclein and its interaction with histones

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4994709

Role of caspase-3 activation in cerebral ischemia-induced neurodegeneration in adult and neonatal brain

3 September 2018

1 reference

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Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

3 September 2018

1 reference

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A semiautomated method for measuring brain infarct volume.

3 September 2018

1 reference

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Inflammation in Parkinson's disease

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27358461

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1523/JNEUROSCI.1241-16.2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27358461%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27358461%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference