In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase (Q37200837)

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scientific article published on 26 March 2009

Language	Label	Description	Also known as
English	In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase	scientific article published on 26 March 2009

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

author name string

Renee M Garza

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Brian K Sato

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Randolph Y Hampton

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

language of work or name

0 references

publication date

26 March 2009

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

284

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

22

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

14710-14722

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Dissecting the ER-associated degradation of a misfolded polytopic membrane protein

1 reference

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A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum

1 reference

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Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis

1 reference

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Determinants of RING-E2 fidelity for Hrd1p, a membrane-anchored ubiquitin ligase

1 reference

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Sel1p/Ubx2p participates in a distinct Cdc48p-dependent endoplasmic reticulum-associated degradation pathway

1 reference

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6 September 2017

Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

1 reference

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A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation

1 reference

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Central pore residues mediate the p97/VCP activity required for ERAD

1 reference

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The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment

1 reference

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Diverse functions with a common regulator: ubiquitin takes command of an AAA ATPase

1 reference

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Functional division of substrate processing cofactors of the ubiquitin-selective Cdc48 chaperone

1 reference

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Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI)

1 reference

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INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins

1 reference

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Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane

1 reference

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6 September 2017

Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane

1 reference

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Ubx2 links the Cdc48 complex to ER-associated protein degradation

1 reference

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Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation

1 reference

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Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol

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Cellular functions, mechanism of action, and regulation of FtsH protease

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Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation.

1 reference

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Checkpoints in ER-associated degradation: excuse me, which way to the proteasome?

1 reference

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A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

1 reference

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A membrane protein required for dislocation of misfolded proteins from the ER

1 reference

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6 September 2017

A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradation

1 reference

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Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy

1 reference

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Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

1 reference

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Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration

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Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8

1 reference

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ER-associated degradation in protein quality control and cellular regulation

1 reference

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Proteolysis and sterol regulation

1 reference

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Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.

1 reference

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HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins

1 reference

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A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation

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The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation

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Proteins containing the UBA domain are able to bind to multi-ubiquitin chains

1 reference

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In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation

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Molecular chaperones in the yeast endoplasmic reticulum maintain the solubility of proteins for retrotranslocation and degradation

1 reference

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Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

1 reference

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Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.

1 reference

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Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p

1 reference

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Recognition of the polyubiquitin proteolytic signal

1 reference

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1 reference

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Reconstitution of retrograde transport from the Golgi to the ER in vitro

1 reference

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The ubiquitin system

1 reference

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Sequence determinants for regulated degradation of yeast 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

1 reference

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Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

1 reference

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Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685653

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ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway

1 reference

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Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685653

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Role of Sec61p in the ER-associated degradation of short-lived transmembrane proteins

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A 'distributed degron' allows regulated entry into the ER degradation pathway

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A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery.

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Structural control of endoplasmic reticulum-associated degradation: effect of chemical chaperones on 3-hydroxy-3-methylglutaryl-CoA reductase

1 reference

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Polyubiquitin serves as a recognition signal, rather than a ratcheting molecule, during retrotranslocation of proteins across the endoplasmic reticulum membrane

1 reference

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1 reference

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Biosynthesis and degradation of CFTR.

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3 September 2018

Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19324879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting

1 reference

https://pubmed.ncbi.nlm.nih.gov/19324879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UBL/UBA ubiquitin receptor proteins bind a common tetraubiquitin chain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19324879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin-specific protease 2 as a tool for quantification of total ubiquitin levels in biological specimens

1 reference

https://pubmed.ncbi.nlm.nih.gov/19324879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M809607200

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

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