Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications (Q37201984)

18 August 2017

Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications (English)

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18 August 2017

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10

Paul G Richardson

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18 August 2017

12

Kenneth C Anderson

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18 August 2017

3

Tanyel Kiziltepe

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18 August 2017

4

Hiroshi Ikeda

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Nikhil C Munshi

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18 August 2017

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Noopur Raje

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18 August 2017

2

Dharminder Chauhan

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18 August 2017

1

Teru Hideshima

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18 August 2017

6

Klaus Podar

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18 August 2017

11

Ruben D Carrasco

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18 August 2017

Yutaka Okawa

5

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18 August 2017

Alexei Protopopov

series ordinal

8

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18 August 2017

language of work or name

English

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publication date

6 March 2009

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18 August 2017

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113

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21

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5228-5236

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describes a project that uses

18 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2686191/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma

6 September 2017

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6 September 2017

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The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis

6 September 2017

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A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

6 September 2017

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6 September 2017

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Wnts induce migration and invasion of myeloma plasma cells

6 September 2017

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IkappaB kinases: key regulators of the NF-kappaB pathway

6 September 2017

1 reference

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Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

6 September 2017

1 reference

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The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma

6 September 2017

1 reference

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A phase 2 study of bortezomib in relapsed, refractory myeloma

6 September 2017

1 reference

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Cell adhesion-mediated drug resistance (CAM-DR) is associated with activation of NF-κB (RelB/p50) in myeloma cells

6 September 2017

1 reference

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Wnt signaling in B-cell neoplasia

6 September 2017

1 reference

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IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf.

6 September 2017

1 reference

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Molecular sequelae of proteasome inhibition in human multiple myeloma cells

6 September 2017

1 reference

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NF-kappaB at the crossroads of life and death

6 September 2017

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NF-kappa B as a therapeutic target in multiple myeloma

6 September 2017

1 reference

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Regulation of beta-catenin function by the IkappaB kinases

6 September 2017

1 reference

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NF-kappaB and cell-cycle regulation: the cyclin connection

6 September 2017

1 reference

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The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686191

IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity

6 September 2017

1 reference

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NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition

6 September 2017

1 reference

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The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

6 September 2017

1 reference

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The NF-kappa B and I kappa B proteins: new discoveries and insights

6 September 2017

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Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells

6 September 2017

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Targeting aurora kinases as therapy in multiple myeloma

14 September 2017

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Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment

14 September 2017

1 reference

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Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686191

Antimyeloma activity of heat shock protein-90 inhibition.

14 September 2017

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1'-acetoxychavicol acetate is a novel nuclear factor kappaB inhibitor with significant activity against multiple myeloma in vitro and in vivo

14 September 2017

1 reference

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Transforming growth factor beta receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686191

Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686191

Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686191

Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-kappaB.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686191

IKKalpha regulates the mitotic phase of the cell cycle by modulating Aurora A phosphorylation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686191

A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686191

NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686191

Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686191

Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686191

Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686191

Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686191

Adhesion to fibronectin via beta1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR).

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2686191

Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19270264

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19270264

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2008-06-161505

1 reference

18 August 2017

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18 August 2017

1 reference