Hypoxia induces netrin-1 and Unc5b in atherosclerotic plaques: mechanism for macrophage retention and survival (Q37222761)

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scientific article published on 18 April 2013

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English	Hypoxia induces netrin-1 and Unc5b in atherosclerotic plaques: mechanism for macrophage retention and survival	scientific article published on 18 April 2013

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29 February 2020

Hypoxia induces netrin-1 and Unc5b in atherosclerotic plaques: mechanism for macrophage retention and survival (English)

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atherosclerosis

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Janine M van Gils

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Edward A Fisher

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Kathryn J. Moore

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Bhama Ramkhelawon

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29 February 2020

Yuan Yang

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29 February 2020

Bernd Hewing

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Scott Oldebeken

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Jessica L Feig

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18 April 2013

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Arteriosclerosis, Thrombosis, and Vascular Biology

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29 February 2020

1180-1188

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29 February 2020

Endothelial expression of guidance cues in vessel wall homeostasis dysregulation under proatherosclerotic conditions

1 reference

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6 September 2017

The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques

1 reference

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6 September 2017

Hypoxia is present in murine atherosclerotic plaques and has multiple adverse effects on macrophage lipid metabolism

1 reference

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6 September 2017

Hypoxia and inflammation

1 reference

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Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesis

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CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima

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Emigration of monocyte-derived cells to lymph nodes during resolution of inflammation and its failure in atherosclerosis

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Regulation of hypoxia-inducible factor-1alpha by NF-kappaB

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6 September 2017

Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice

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6 September 2017

Netrin-1 inhibits leukocyte migration in vitro and in vivo.

1 reference

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6 September 2017

Netrin-1 controls colorectal tumorigenesis by regulating apoptosis

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Targeting HIF-1 for cancer therapy

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UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE

1 reference

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6 September 2017

Netrin-1 acts as a survival factor via its receptors UNC5H and DCC.

1 reference

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The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation

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The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease

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CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 c

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6 September 2017

Atherosclerosis is an inflammatory disease

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Elevated plasma membrane cholesterol content alters macrophage signaling and function.

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14 September 2017

Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1alpha (HIF-1alpha) accumulation via redox-dependent mechanisms

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CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2.

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Netrin-1 overexpression protects kidney from ischemia reperfusion injury by suppressing apoptosis.

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26 June 2018

Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia.

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3 September 2018

Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis

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3 September 2018

Vascular endothelial growth factor enhances atherosclerotic plaque progression

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3 September 2018

Induction of apoptosis and G2/M cell cycle arrest by DCC.

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3 September 2018

Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury

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12 December 2020

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Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1

1 reference

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12 December 2020

based on heuristic

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Hypoxia Converts Human Macrophages Into Triglyceride-Loaded Foam Cells

1 reference

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12 December 2020

based on heuristic

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Effect of chemical stabilizers of hypoxia-inducible factors on early lung development

1 reference

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12 December 2020

based on heuristic

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HIF-1 alpha expression is associated with an atheromatous inflammatory plaque phenotype and upregulated in activated macrophages

1 reference

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12 December 2020

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Identifiers

10.1161/ATVBAHA.112.301008

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29 February 2020

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29 February 2020

1 reference

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29 February 2020

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