Prospects for homologous recombination in human gene therapy (Q37223531)

19 August 2017

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title

Prospects for homologous recombination in human gene therapy (English)

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19 August 2017

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genetic recombination

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1864597

12 December 2022

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12 December 2022

author name string

M. A. Vega

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1864597

12 December 2022

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1864597

12 December 2022

publication date

1 July 1991

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full work available at URL

19 August 2017

http://link.springer.com/content/pdf/10.1007/BF00200899.pdf

file format

Portable Document Format

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http://link.springer.com/article/10.1007/BF00200899/fulltext.html

12 December 2022

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http://link.springer.com/content/pdf/10.1007/BF00200899

12 December 2022

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12 December 2022

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19 August 2017

87

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19 August 2017

3

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19 August 2017

245-253

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https://scigraph.springernature.com/pub.10.1007/bf00200899

19 August 2017

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cites work

Mechanisms of nonhomologous recombination in mammalian cells

1 reference

12 December 2020

Site-specific gene expression in vivo by direct gene transfer into the arterial wall

1 reference

12 December 2020

Research and potential clinical applications of retroviral vectors

1 reference

12 December 2020

Homologous recombination of SV40 DNA in COS7 cells occurs with high frequency in a gene dose independent fashion

1 reference

12 December 2020

Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene.

1 reference

12 December 2020

Correction of CD18-deficient lymphocytes by retrovirus-mediated gene transfer

1 reference

12 December 2020

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1 reference

12 December 2020

Homologous recombination in hybridoma cells: heavy chain chimeric antibody produced by gene targeting

1 reference

12 December 2020

Expression of human class II major histocompatibility complex antigens using retrovirus vectors

1 reference

12 December 2020

Retroviral integration sites in transgenic Mov mice frequently map in the vicinity of transcribed DNA regions.

1 reference

12 December 2020

Recombinant gene expression in vivo within endothelial cells of the arterial wall

1 reference

12 December 2020

Homologous recombination in mammalian cells

1 reference

12 December 2020

Retroviral vectors expressing soluble CD4: a potential gene therapy for AIDS.

1 reference

12 December 2020

Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells.

1 reference

12 December 2020

Left-handed Z-DNA and genetic recombination.

1 reference

12 December 2020

Retroviral-mediated gene transfer

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12 December 2020

Enrichment of murine haemopoietic stem cells: diverging roads

1 reference

12 December 2020

Retrovirus-mediated transfer of human adenosine deaminase gene sequences into cells in culture and into murine hematopoietic cells in vivo

1 reference

12 December 2020

Long-term transplantation of canine keratinocytes made resistant to G418 through retrovirus-mediated gene transfer

1 reference

12 December 2020

Hypervariable minisatellite DNA is a hotspot for homologous recombination in human cells

1 reference

12 December 2020

Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells

1 reference

12 December 2020

Targeting of nonexpressed genes in embryonic stem cells via homologous recombination

1 reference

12 December 2020

Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells

1 reference

12 December 2020

The new mouse genetics: altering the genome by gene targeting

1 reference

12 December 2020

Insertion of genes into retrovirus genomes and of retrovirus DNA into cell genomes

1 reference

12 December 2020

Human purine nucleoside phosphorylase and adenosine deaminase: gene transfer into cultured cells and murine hematopoietic stem cells by using recombinant amphotropic retroviruses

1 reference

12 December 2020

Recombination events during integration of transfected DNA into normal human cells

1 reference

12 December 2020

Identification of homologous pairing and strand-exchange activity from a human tumor cell line based on Z-DNA affinity chromatography

1 reference

12 December 2020

Mutations in the human adenosine deaminase gene that affect protein structure and RNA splicing

1 reference

12 December 2020

Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells

1 reference

12 December 2020

Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells

1 reference

12 December 2020

Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination

1 reference

12 December 2020

Human gene transfer: characterization of human tumor-infiltrating lymphocytes as vehicles for retroviral-mediated gene transfer in man

1 reference

12 December 2020

One adenosine deaminase allele in a patient with severe combined immunodeficiency contains a point mutation abolishing enzyme activity

1 reference

12 December 2020

Modification of DNA ends can decrease end joining relative to homologous recombination in mammalian cells

1 reference

12 December 2020

Retrovirus-mediated transgenic keratin expression in cultured fibroblasts: Specific domain functions in keratin stabilization and filament formation

1 reference

12 December 2020

Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination

1 reference

12 December 2020

Heteroduplex-induced mutagenesis in mammalian cells

1 reference

12 December 2020

Expression of functional factor VIII in primary human skin fibroblasts after retrovirus-mediated gene transfer.

1 reference

12 December 2020

Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination

1 reference

12 December 2020

Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells

1 reference

12 December 2020

Efficient retrovirus-mediated transfer and expression of a human adenosine deaminase gene in diploid skin fibroblasts from an adenosine deaminase-deficient human

1 reference

12 December 2020

Mutant human adenosine deaminase alleles and their expression by transfection into fibroblasts

1 reference

12 December 2020

Prospects for gene therapy for immunodeficiency diseases

1 reference

12 December 2020

Gene therapy: into the home stretch

1 reference

12 December 2020

Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

1 reference

12 December 2020

Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells.

1 reference

12 December 2020

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.

1 reference

12 December 2020

Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells

1 reference

12 December 2020

Deletion in a recombinant retroviral vector resulting from a cryptic splice donor signal in the Moloney leukemia virus envelope gene

1 reference

12 December 2020

High frequency targeting of genes to specific sites in the mammalian genome

1 reference

12 December 2020

Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules

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12 December 2020

Short DNA fragments induce site specific recombination in mammalian cells

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12 December 2020

Evidence for a complex regulatory array in the first intron of the human adenosine deaminase gene

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12 December 2020

Recombination in mouse L cells between DNA introduced into cells and homologous chromosomal sequences

1 reference

12 December 2020

Genes transferred by retroviral vectors into normal and mutant myoblasts in primary cultures are expressed in myotubes

1 reference

12 December 2020

Retroviral vector-mediated high-efficiency expression of adenosine deaminase (ADA) in hematopoietic long-term cultures of ADA-deficient marrow cells

1 reference

12 December 2020

Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells

1 reference

12 December 2020

High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination

1 reference

12 December 2020

Prospects for Human Gene Therapy

1 reference

12 December 2020

Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer

1 reference

12 December 2020

Illegitimate and homologous recombination in mammalian cells: differential sensitivity to an inhibitor of poly(ADP-ribosylation).

1 reference

12 December 2020

Altering the genome by homologous recombination

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12 December 2020

Designing cells to deliver drugs

1 reference

12 December 2020

Highly preferred targets for retrovirus integration

1 reference

12 December 2020

"Pure" human hematopoietic progenitors: permissive action of basic fibroblast growth factor

1 reference

12 December 2020

Production of glycosylated physiologically "normal" human alpha 1-antitrypsin by mouse fibroblasts modified by insertion of a human alpha 1-antitrypsin cDNA using a retroviral vector

1 reference

12 December 2020

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1 reference

12 December 2020

Expression of human adenosine deaminase in mice reconstituted with retrovirus-transduced hematopoietic stem cells

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12 December 2020

Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination.

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12 December 2020

A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact

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12 December 2020

Gene targeting at the human CD4 locus by epitope addition

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12 December 2020

Lineage-specific expression of a human beta-globin gene in murine bone marrow transplant recipients reconstituted with retrovirus-transduced stem cells

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12 December 2020

Gene transfer into primates and prospects for gene therapy in humans

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12 December 2020

Evidence for a stem cell-specific repressor of Moloney murine leukemia virus expression in embryonal carcinoma cells

1 reference

12 December 2020

Expression of human alpha-globin and mouse/human hybrid beta-globin genes in murine hemopoietic stem cells transduced by recombinant retroviruses

1 reference

12 December 2020

Targeted mutation of the Hprt gene in mouse embryonic stem cells

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12 December 2020

A recombination hotspot in the LTR of a mouse retrotransposon identified in an in vitro system

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12 December 2020

Adenosine deaminase: characterization and expression of a gene with a remarkable promoter

1 reference

12 December 2020

Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges

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12 December 2020

Homologous pairing in genetic recombination. The pairing reaction catalyzed by Escherichia coli recA protein

1 reference

12 December 2020

The serial cultivation of human diploid cell strains

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12 December 2020

Severe combined immune deficiency due to a homozygous 3.2-kb deletion spanning the promoter and first exon of the adenosine deaminase gene

1 reference

12 December 2020

Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver--conditioned medium.

1 reference

12 December 2020

Progress toward human gene therapy

1 reference

12 December 2020

Expression of an exogenous growth hormone gene by transplantable human epidermal cells

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF00200899

1 reference

19 August 2017

1 reference