Differential regulation of receptor activation and agonist selectivity by highly conserved tryptophans in the nicotinic acetylcholine receptor binding site (Q37237079)

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scientific article published on April 2009

Language	Label	Description	Also known as
English	Differential regulation of receptor activation and agonist selectivity by highly conserved tryptophans in the nicotinic acetylcholine receptor binding site	scientific article published on April 2009

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scholarly article

1 reference

Europe PubMed Central

19 August 2017

Differential regulation of receptor activation and agonist selectivity by highly conserved tryptophans in the nicotinic acetylcholine receptor binding site (English)

1 reference

Europe PubMed Central

19 August 2017

author name string

Dustin K Williams

1

1 reference

Europe PubMed Central

19 August 2017

Clare Stokes

2

1 reference

Europe PubMed Central

19 August 2017

Nicole A Horenstein

3

1 reference

Europe PubMed Central

19 August 2017

Roger L Papke

4

1 reference

Europe PubMed Central

19 August 2017

language of work or name

0 references

publication date

1 April 2009

1 reference

Europe PubMed Central

19 August 2017

Journal of Pharmacology and Experimental Therapeutics

1 reference

Europe PubMed Central

19 August 2017

330

1 reference

Europe PubMed Central

19 August 2017

1

1 reference

Europe PubMed Central

19 August 2017

40-53

1 reference

Europe PubMed Central

19 August 2017

Nicotine binding to brain receptors requires a strong cation-pi interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2700159

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Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine

1 reference

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9 September 2017

Muscle and neuronal nicotinic acetylcholine receptors. Structure, function and pathogenicity.

1 reference

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9 September 2017

Galanthamine and Non-competitive Inhibitor Binding to ACh-binding Protein: Evidence for a Binding Site on Non-α-subunit Interfaces of Heteromeric Neuronal Nicotinic Receptors

1 reference

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Development and validation of a modular, extensible docking program: DOCK 5.

1 reference

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9 September 2017

Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system

1 reference

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9 September 2017

Brain nicotinic acetylcholine receptors: native subtypes and their relevance.

1 reference

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The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

1 reference

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Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

1 reference

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Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels

1 reference

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UCSF Chimera--a visualization system for exploratory research and analysis

1 reference

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Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

1 reference

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The SWISS-MODEL Repository of annotated three-dimensional protein structure homology models

1 reference

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9 September 2017

SWISS-MODEL: An automated protein homology-modeling server

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2700159

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Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression

1 reference

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9 September 2017

Comparative pharmacology of rat and human alpha7 nAChR conducted with net charge analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2700159

9 September 2017

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2700159

9 September 2017

From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor

1 reference

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Using CLUSTAL for multiple sequence alignments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2700159

9 September 2017

Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2700159

9 September 2017

Roles of accessory subunits in alpha4beta2(*) nicotinic receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2700159

14 September 2017

Evolutionary history of the ligand-gated ion-channel superfamily of receptors

1 reference

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14 September 2017

Neuronal nicotinic receptors: molecular organization and regulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2700159

14 September 2017

Functional architecture of the nicotinic acetylcholine receptor: a prototype of ligand-gated ion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2700159

14 September 2017

Conserved tyrosines in the alpha subunit of the nicotinic acetylcholine receptor stabilize quaternary ammonium groups of agonists and curariform antagonists.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2700159

26 June 2018

Functional significance of aromatic amino acids from three peptide loops of the alpha 7 neuronal nicotinic receptor site investigated by site-directed mutagenesis

1 reference

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Mutational analysis of ligand-induced activation of the Torpedo acetylcholine receptor

1 reference

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26 June 2018

Aromatic residues at position 55 of rat alpha7 nicotinic acetylcholine receptors are critical for maintaining rapid desensitization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2700159

3 September 2018

Reversal of agonist selectivity by mutations of conserved amino acids in the binding site of nicotinic acetylcholine receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2700159

3 September 2018

Estimation of both the potency and efficacy of alpha7 nAChR agonists from single-concentration responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2700159

3 September 2018

Different binding orientations for the same agonist at homologous receptors: a lock and key or a simple wedge?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2700159

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Specific activation of the alpha 7 nicotinic acetylcholine receptor by a quaternary analog of cocaine.

1 reference

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3 September 2018

Contributions of Torpedo nicotinic acetylcholine receptor gamma Trp-55 and delta Trp-57 to agonist and competitive antagonist function

1 reference

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The correction of alpha7 nicotinic acetylcholine receptor concentration-response relationships in Xenopus oocytes.

1 reference

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3 September 2018

Structure of the agonist-binding site of the nicotinic acetylcholine receptor. [3H]acetylcholine mustard identifies residues in the cation-binding subsite

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand-receptor interactions in the nicotinic acetylcholine receptor probed using multiple substitutions at conserved tyrosines on the alpha subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of amino acids contributing to high and low affinity d-tubocurarine sites in the Torpedo nicotinic acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of tryptophan 55 as the primary site of [3H]nicotine photoincorporation in the gamma-subunit of the Torpedo nicotinic acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/JPET.109.151225

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

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