Follow the leader: the use of leader peptides to guide natural product biosynthesis. (Q37237843)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20016494%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

review article

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title

Follow the leader: the use of leader peptides to guide natural product biosynthesis (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20016494%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20016494%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

author name string

Trent J Oman

series ordinal

1

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15 January 2020

publication date

1 January 2010

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20016494%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

published in

Nature Chemical Biology

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15 January 2020

volume

6

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15 January 2020

page(s)

9-18

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15 January 2020

issue

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20016494%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nchembio.286

15 January 2020

exact match

0 references

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Use of lantibiotic synthetases for the preparation of bioactive constrained peptides

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Genetic features of circular bacteriocins produced by Gram-positive bacteria.

6 September 2017

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Gene family encoding the major toxins of lethal Amanita mushrooms

6 September 2017

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Biosynthetic tailoring of microcin E492m: post-translational modification affords an antibacterial siderophore-peptide conjugate

6 September 2017

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Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin

6 September 2017

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The leader peptide is not required for post-translational modification by lacticin 481 synthetase

6 September 2017

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Two enzymes catalyze the maturation of a lasso peptide in Escherichia coli

6 September 2017

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Microcins, gene-encoded antibacterial peptides from enterobacteria

6 September 2017

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Lantibiotics: peptides of diverse structure and function.

6 September 2017

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Production of dehydroamino acid-containing peptides by Lactococcus lactis.

6 September 2017

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Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic

6 September 2017

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Conotoxins and the posttranslational modification of secreted gene products

6 September 2017

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The impact of bacterial genomics on natural product research.

6 September 2017

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Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin

6 September 2017

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Shotgun cloning and heterologous expression of the patellamide gene cluster as a strategy to achieving sustained metabolite production

6 September 2017

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Precursors of novel Gla-containing conotoxins contain a carboxy-terminal recognition site that directs gamma-carboxylation

6 September 2017

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Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella

6 September 2017

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Polypeptide chains containing D-gamma-hydroxyvaline

6 September 2017

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6 September 2017

Thiopeptide antibiotics

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Biosynthesis and mode of action of lantibiotics.

6 September 2017

1 reference

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Formation of disulfide bonds in proteins and peptides

6 September 2017

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Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins

6 September 2017

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6 September 2017

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Siderophore peptide, a new type of post-translationally modified antibacterial peptide with potent activity

6 September 2017

1 reference

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NMR solution structure of the precursor for carnobacteriocin B2, an antimicrobial peptide from Carnobacterium piscicola

6 September 2017

1 reference

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Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity

6 September 2017

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The Spo0A regulon of Bacillus subtilis

6 September 2017

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Efficient oxidative folding of conotoxins and the radiation of venomous cone snails

6 September 2017

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Structure of Microcin J25, a Peptide Inhibitor of Bacterial RNA Polymerase, is a Lassoed Tail

6 September 2017

1 reference

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Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone

6 September 2017

1 reference

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Structure of antibacterial peptide microcin J25: a 21-residue lariat protoknot

6 September 2017

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6 September 2017

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Structure of subtilosin A, an antimicrobial peptide from Bacillus subtilis with unusual posttranslational modifications linking cysteine sulfurs to alpha-carbons of phenylalanine and threonine

6 September 2017

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Biosynthesis and insecticidal properties of plant cyclotides: the cyclic knotted proteins from Oldenlandia affinis

6 September 2017

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In vitro characterization of DNA gyrase inhibition by microcin B17 analogs with altered bisheterocyclic sites

6 September 2017

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Effect of amino acid substitutions in conserved residues in the leader peptide on biosynthesis of the lantibiotic mutacin II.

6 September 2017

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Genetic locus for streptolysin S production by group A streptococcus

6 September 2017

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Genes of the sbo-alb locus of Bacillus subtilis are required for production of the antilisterial bacteriocin subtilosin

6 September 2017

1 reference

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Post-translationally modified neuropeptides from Conus venoms

6 September 2017

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Speciation of cone snails and interspecific hyperdivergence of their venom peptides. Potential evolutionary significance of introns

6 September 2017

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In vivo processing and antibiotic activity of microcin B17 analogs with varying ring content and altered bisheterocyclic sites

6 September 2017

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Cofactor requirements and reconstitution of microcin B17 synthetase: a multienzyme complex that catalyzes the formation of oxazoles and thiazoles in the antibiotic microcin B17.

6 September 2017

1 reference

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Role of the microcin B17 propeptide in substrate recognition: solution structure and mutational analysis of McbA1-26

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Structural features of the final intermediate in the biosynthesis of the lantibiotic nisin. Influence of the leader peptide

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Use of alkaline phosphatase as a reporter polypeptide to study the role of the subtilin leader segment and the SpaT transporter in the posttranslational modifications and secretion of subtilin in Bacillus subtilis 168.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Constant and hypervariable regions in conotoxin propeptides

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S.

6 September 2017

1 reference

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Improvement of solubility and stability of the antimicrobial peptide nisin by protein engineering.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Protein engineering of lantibiotics.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Directionality and coordination of dehydration and ring formation during biosynthesis of the lantibiotic nisin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Systematic structure-activity analysis of microcin J25.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Cloning and characterization of the goadsporin biosynthetic gene cluster from Streptomyces sp. TP-A0584.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

NisT, the transporter of the lantibiotic nisin, can transport fully modified, dehydrated, and unmodified prenisin and fusions of the leader peptide with non-lantibiotic peptides.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Function of bacterial propeptides

26 June 2018

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From peptide precursors to oxazole and thiazole-containing peptide antibiotics: microcin B17 synthase.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

The maturation pathway of microcin B17, a peptide inhibitor of DNA gyrase.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Chemical structure and translation inhibition studies of the antibiotic microcin C7.

26 June 2018

1 reference

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Substrate specificity and scope of MvdD, a GRASP-like ligase from the microviridin biosynthetic gene cluster.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Intra-molecular chaperone: the role of the N-terminal in conformational selection and kinetic control.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Using marine natural products to discover a protease that catalyzes peptide macrocyclization of diverse substrates

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

The generation of nisin variants with enhanced activity against specific gram-positive pathogens.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Role of hydroxyprolines in the in vitro oxidative folding and biological activity of conotoxins.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

NisC, the cyclase of the lantibiotic nisin, can catalyze cyclization of designed nonlantibiotic peptides

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

An asparaginyl endopeptidase mediates in vivo protein backbone cyclization.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Complete alanine scanning of the two-component lantibiotic lacticin 3147: generating a blueprint for rational drug design.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Structure of the Bacillus subtilis quorum-sensing peptide pheromone ComX.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Membrane anchoring of the AgrD N-terminal amphipathic region is required for its processing to produce a quorum-sensing pheromone in Staphylococcus aureus.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

A novel post-translational modification involving bromination of tryptophan. Identification of the residue, L-6-bromotryptophan, in peptides from Conus imperialis and Conus radiatus venom

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

The leader peptide of colicin V shares consensus sequences with leader peptides that are common among peptide bacteriocins produced by gram-positive bacteria.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Gamma-carboxyglutamate in a neuroactive toxin.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Enhancement of the chemical and antimicrobial properties of subtilin by site-directed mutagenesis

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Distribution and evolution of circular miniproteins in flowering plants

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3799897

Influence of amino acid substitutions in the nisin leader peptide on biosynthesis and secretion of nisin by Lactococcus lactis

4 December 2018

1 reference

12 December 2020

The leader peptide is essential for the post-translational modification of the DNA-gyrase inhibitor microcin B17

1 reference

12 December 2020

Conantokin-G precursor and its role in gamma-carboxylation by a vitamin K-dependent carboxylase from a Conus snail

1 reference

12 December 2020

Mutational analysis of posttranslational heterocycle biosynthesis in the gyrase inhibitor microcin B17: distance dependence from propeptide and tolerance for substitution in a GSCG cyclizable sequence

1 reference

12 December 2020

Identification of a novel two-peptide lantibiotic, haloduracin, produced by the alkaliphile Bacillus halodurans C-125

1 reference

12 December 2020

Propeptide does not act as an intramolecular chaperone but facilitates protein disulfide isomerase-assisted folding of a conotoxin precursor

1 reference

12 December 2020

Novel gamma-carboxyglutamic acid-containing peptides from the venom of Conus textile

1 reference

12 December 2020

Posttranslational heterocyclization of cysteine and serine residues in the antibiotic microcin B17: distributivity and directionality

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.286

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20016494%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20016494%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference