"It is the antigen(s), stupid" and other lessons from over a decade of vaccitherapy of human cancer. (Q37248131)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18715801%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

review article

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title

"It is the antigen(s), stupid" and other lessons from over a decade of vaccitherapy of human cancer (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18715801%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

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Matthew R Buckwalter

1

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12 January 2020

Pramod K Srivastava

series ordinal

2

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12 January 2020

publication date

20 August 2008

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12 January 2020

published in

Seminars in Immunology

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12 January 2020

volume

20

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12 January 2020

issue

5

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12 January 2020

page(s)

296-300

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A natural cytotoxic T cell response in a spontaneously regressing human melanoma targets a neoantigen resulting from a somatic point mutation

12 January 2020

cites work

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12 December 2020

High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993

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12 December 2020

Two antigens recognized by autologous cytolytic T lymphocytes on a melanoma result from a single point mutation in an essential housekeeping gene.

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12 December 2020

High frequency of autologous anti-melanoma CTL directed against an antigen generated by a point mutation in a new helicase gene.

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12 December 2020

Immunotherapy of human cancer: lessons from mice

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12 December 2020

The immunoprotective MHC II epitope of a chemically induced tumor harbors a unique mutation in a ribosomal protein

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12 December 2020

Heat shock protein-chaperoned peptides but not free peptides introduced into the cytosol are presented efficiently by major histocompatibility complex I molecules

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12 December 2020

High frequency of cytolytic T lymphocytes directed against a tumor-specific mutated antigen detectable with HLA tetramers in the blood of a lung carcinoma patient with long survival

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12 December 2020

A point mutation in the alpha-actinin-4 gene generates an antigenic peptide recognized by autologous cytolytic T lymphocytes on a human lung carcinoma

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12 December 2020

Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses

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12 December 2020

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

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12 December 2020

Determinants of efficacy of immunotherapy with tumor-derived heat shock protein gp96

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12 December 2020

Stroma is critical for preventing or permitting immunological destruction of antigenic cancer cells

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12 December 2020

On the role of unmutated antigens in tumor rejection in mice with unperturbed T-cell repertoires

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12 December 2020

The Group II Chaperonin TRiC Protects Proteolytic Intermediates from Degradation in the MHC Class I Antigen Processing Pathway

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12 December 2020

Genetically engineered mouse models of mammary intraepithelial neoplasia

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12 December 2020

Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer

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12 December 2020

Cancer immunotherapy with mRNA-transfected dendritic cells

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12 December 2020

Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma

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12 December 2020

Immunogenicity without immunoselection: a mutant but functional antioxidant enzyme retained in a human metastatic melanoma and targeted by CD8(+) T cells with a memory phenotype

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12 December 2020

Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8+ T cells in patients with melanoma

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12 December 2020

The response of autologous T cells to a human melanoma is dominated by mutated neoantigens

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12 December 2020

A point mutation in the NFYC gene generates an antigenic peptide recognized by autologous cytolytic T lymphocytes on a human squamous cell lung carcinoma

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12 December 2020

Effective cancer therapy through immunomodulation

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12 December 2020

The role of stroma in immune recognition and destruction of well-established solid tumors

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12 December 2020

Prognostic significance of autoimmunity during treatment of melanoma with interferon.

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12 December 2020

Immuno-gene therapy of cancer with tumour-mRNA transfected dendritic cells

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12 December 2020

Hsp90alpha chaperones large C-terminally extended proteolytic intermediates in the MHC class I antigen processing pathway

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12 December 2020

Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

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12 December 2020

Fast-tracked CTL: rapid induction of potent anti-tumor killer T cells in situ.

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12 December 2020

Maximizing mouse cancer models

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12 December 2020

Modelling breast cancer: one size does not fit all.

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12 December 2020

The origins of oncomice: a history of the first transgenic mice genetically engineered to develop cancer

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12 December 2020

Murine models of chronic lymphocytic leukaemia: role of microRNA-16 in the New Zealand Black mouse model

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12 December 2020

Heat-shock protein 90 associates with N-terminal extended peptides and is required for direct and indirect antigen presentation

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12 December 2020

Phase III comparison of vitespen, an autologous tumor-derived heat shock protein gp96 peptide complex vaccine, with physician's choice of treatment for stage IV melanoma: the C-100-21 Study Group.

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12 December 2020

Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients

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12 December 2020

Graft-versus-leukemia reactions after bone marrow transplantation

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12 December 2020

Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers

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12 December 2020

Individually distinct transplantation antigens of chemically induced mouse tumors

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12 December 2020

A clinical trial of anti-idiotype therapy for B cell malignancy

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12 December 2020

Multiple lineages of tumors express a common tumor antigen, P1A, but they are not cross-protected.

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12 December 2020

A unique tumor antigen produced by a single amino acid substitution

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12 December 2020

A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma

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12 December 2020

Peptide-binding heat shock proteins in the endoplasmic reticulum: role in immune response to cancer and in antigen presentation.

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12 December 2020

Heat shock proteins transfer peptides during antigen processing and CTL priming

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12 December 2020

Metastatic prostate cancer in a transgenic mouse

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12 December 2020

Unique tumor antigens redefined as mutant tumor-specific antigens

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12 December 2020

Do human cancers express shared protective antigens? or the necessity of remembrance of things past

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12 December 2020

The immunodominant antigen of an ultraviolet-induced regressor tumor is generated by a somatic point mutation in the DEAD box helicase p68

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12 December 2020

Mutated mitogen-activated protein kinase: a tumor rejection antigen of mouse sarcoma

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12 December 2020

Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations

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12 December 2020

Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program.

1 reference

12 December 2020

10.1016/J.SMIM.2008.07.003

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18715801%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18715801%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

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