Therapeutic evaluation of ex vivo-generated versus natural regulatory T-cells in a mouse model of chronic gut inflammation. (Q37265675)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23893082%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

Therapeutic evaluation of ex vivo-generated versus natural regulatory T-cells in a mouse model of chronic gut inflammation (English)

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6 March 2020

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5

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6 March 2020

author name string

Fridrik Karlsson

1

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6 March 2020

Nicholas E Martinez

2

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6 March 2020

Laura Gray

3

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6 March 2020

Songlin Zhang

4

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6 March 2020

Matthew B Grisham

6

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6 March 2020

publication date

1 October 2013

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Inflammatory Bowel Diseases

6 March 2020

published in

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6 March 2020

volume

19

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6 March 2020

issue

11

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6 March 2020

page(s)

2282-2294

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Antigen-specific transforming growth factor β-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17/Treg cell balance from Th17 predominance to Treg cell predominance.

6 March 2020

cites work

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6 September 2017

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6 September 2017

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6 September 2017

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Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity

6 September 2017

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6 September 2017

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IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo

6 September 2017

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Regulatory T cells and Foxp3

6 September 2017

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Role of the endothelium in inflammatory bowel diseases

6 September 2017

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Pharmacological intervention studies using mouse models of the inflammatory bowel diseases: translating preclinical data into new drug therapies

6 September 2017

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CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype

6 September 2017

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Cutting edge: all-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu.

6 September 2017

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Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine.

6 September 2017

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Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells

6 September 2017

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Control of alpha4beta7 integrin expression and CD4 T cell homing by the beta1 integrin subunit

6 September 2017

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Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells

6 September 2017

1 reference

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Regulatory T cells reinforce intestinal homeostasis

6 September 2017

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Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

6 September 2017

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Conveying glycan information into T-cell homeostatic programs: a challenging role for galectin-1 in inflammatory and tumor microenvironments.

6 September 2017

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LFA-1 is critical for regulatory T cell homeostasis and function

6 September 2017

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A central role for induced regulatory T cells in tolerance induction in experimental colitis

6 September 2017

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6 September 2017

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Cutting edge: antigen-specific TGF beta-induced regulatory T cells suppress Th17-mediated autoimmune disease

6 September 2017

1 reference

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DC activated via dectin-1 convert Treg into IL-17 producers

6 September 2017

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T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade

6 September 2017

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Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells

6 September 2017

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Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans.

6 September 2017

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Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

6 September 2017

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Molecular antagonism and plasticity of regulatory and inflammatory T cell programs

6 September 2017

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How regulatory T cells work

6 September 2017

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The inhibitory cytokine IL-35 contributes to regulatory T-cell function

6 September 2017

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Homing imprinting and immunomodulation in the gut: role of dendritic cells and retinoids

6 September 2017

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All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation

6 September 2017

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A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism

6 September 2017

1 reference

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OX40 costimulation turns off Foxp3+ Tregs.

6 September 2017

1 reference

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Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid

6 September 2017

1 reference

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Foxp3 in control of the regulatory T cell lineage

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3812251

The fundamental basis of inflammatory bowel disease

6 September 2017

1 reference

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Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation

6 September 2017

1 reference

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Regulatory T-cell physiology and application to treat autoimmunity

6 September 2017

1 reference

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Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease

6 September 2017

1 reference

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Statistical analysis of real-time PCR data

6 September 2017

1 reference

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Failure of CD25+ T cells from lupus-prone mice to suppress lupus glomerulonephritis and sialoadenitis

6 September 2017

1 reference

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Regulatory T cell lineage specification by the forkhead transcription factor foxp3

6 September 2017

1 reference

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In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes

6 September 2017

1 reference

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

6 September 2017

1 reference

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Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells

6 September 2017

1 reference

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Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide

6 September 2017

1 reference

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Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease

6 September 2017

1 reference

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Ex Vivo Generation of Regulatory T Cells: Characterization and Therapeutic Evaluation in a Model of Chronic Colitis

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3812251

Stability of the regulatory T cell lineage in vivo.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3812251

In vivo sites and cellular mechanisms of T reg cell-mediated suppression

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3812251

Transforming growth factor-beta and all-trans retinoic acid generate ex vivo transgenic regulatory T cells with intestinal homing receptors

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3812251

SHIP regulates the reciprocal development of T regulatory and Th17 cells

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3812251

Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3812251

CD25+CD4+ regulatory T cell migration requires L-selectin expression: L-selectin transcriptional regulation balances constitutive receptor turnover.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3812251

Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3812251

CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3812251

Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis.

3 September 2018

1 reference

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Cutting edge: CD4+CD25+ regulatory T cells impaired for intestinal homing can prevent colitis.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3812251

Apoptosis of T cells mediated by galectin-1.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3812251

CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10

3 September 2018

1 reference

12 December 2020

A Comparative Study between T Regulatory Type 1 and CD4+CD25+ T Cells in the Control of Inflammation

1 reference

12 December 2020

T cell-induced inflammation of the small and large intestine in immunodeficient mice

1 reference

12 December 2020

Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of Colitis

1 reference

12 December 2020

Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta

1 reference

12 December 2020

In vitro generation of CD4+ CD25+ regulatory cells from murine naive T cells

1 reference

12 December 2020

Vitamin A Metabolites Induce Gut-Homing FoxP3+ Regulatory T Cells

1 reference

12 December 2020

Competition for cytokines: T(reg) cells take all

1 reference

12 December 2020

A non-redundant role for OX40 in the competitive fitness of Treg in response to IL-2

1 reference

12 December 2020

CD8+CD122+ regulatory T cells (Tregs) and CD4+ Tregs cooperatively prevent and cure CD4+ cell-induced colitis

1 reference

12 December 2020

The influence of excessive IL-6 production in vivo on the development and function of Foxp3+ regulatory T cells

1 reference

12 December 2020

T cell-associated CD18 but not CD62L, ICAM-1, or PSGL-1 is required for the induction of chronic colitis

1 reference

12 December 2020

Natural but not inducible regulatory T cells require TNF-alpha signaling for in vivo function

1 reference

12 December 2020

10.1097/MIB.0B013E31829C32DD

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23893082%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23893082%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

PubMed publication ID

23893082

1 reference