Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation. (Q37273279)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19332876%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

title

Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation (English)

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25 January 2020

6

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25 January 2020

author name string

Atsushi Hosui

1

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25 January 2020

Akiko Kimura

2

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25 January 2020

Daisuke Yamaji

3

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25 January 2020

Bing-mei Zhu

4

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25 January 2020

Risu Na

5

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25 January 2020

language of work or name

English

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publication date

30 March 2009

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Journal of Experimental Medicine

25 January 2020

published in

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25 January 2020

volume

206

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25 January 2020

issue

4

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25 January 2020

page(s)

819-831

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Genomic dissection of the cytokine-controlled STAT5 signaling network in liver

25 January 2020

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STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output

6 September 2017

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TLR4 enhances TGF-beta signaling and hepatic fibrosis

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Disruption of the latent transforming growth factor-beta binding protein-1 gene causes alteration in facial structure and influences TGF-beta bioavailability

6 September 2017

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Signalling cross-talk between hepatocyte nuclear factor 4alpha and growth-hormone-activated STAT5b

6 September 2017

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6 September 2017

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Constitutive activation of Stat5b contributes to carcinogenesis in vivo

6 September 2017

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Evidence that fibroblasts derive from epithelium during tissue fibrosis

6 September 2017

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AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

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6 September 2017

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Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction

6 September 2017

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Normal growth and development in the absence of hepatic insulin-like growth factor I

6 September 2017

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Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

6 September 2017

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Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro

6 September 2017

1 reference

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Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

6 September 2017

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STATs and gene regulation

6 September 2017

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Functional interactions between Stat5 and the glucocorticoid receptor

6 September 2017

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Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia

6 September 2017

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Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.

6 September 2017

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Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells

6 September 2017

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Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts

6 September 2017

1 reference

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Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family

6 September 2017

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In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis

6 September 2017

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6 September 2017

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STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression

14 September 2017

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Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro

14 September 2017

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Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition.

14 September 2017

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EGFR is phosphorylated at Ty845 in hepatocellular carcinoma

14 September 2017

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TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

14 September 2017

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Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

14 September 2017

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The coactivator of transcription CREB-binding protein interacts preferentially with the glycosylated form of Stat5.

14 September 2017

1 reference

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Hepatitis C virus core protein differently regulates the JAK-STAT signaling pathway under interleukin-6 and interferon-gamma stimuli

14 September 2017

1 reference

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Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

14 September 2017

1 reference

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A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715112

Mediation of growth hormone-dependent transcriptional activation by mammary gland factor/Stat 5.

28 September 2017

1 reference

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Stat5a serine phosphorylation. Serine 779 is constitutively phosphorylated in the mammary gland, and serine 725 phosphorylation influences prolactin-stimulated in vitro DNA binding activity.

28 September 2017

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Cirrhotic liver expresses low levels of the full-length and truncated growth hormone receptors.

26 June 2018

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Growth hormone, insulinlike growth factor-1, and insulinlike growth factor binding proteins 1 and 3 in chronic liver disease.

26 June 2018

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Hypoxia potentiates transforming growth factor-beta expression of hepatocyte during the cirrhotic condition in rat liver

26 June 2018

1 reference

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Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2715112

SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity

3 September 2018

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Short-term effect of recombinant human growth hormone in patients with alcoholic cirrhosis

3 September 2018

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Crossref

https://api.crossref.org/works/10.1084%2FJEM.20080003

Stat5 tetramer formation is associated with leukemogenesis

21 January 2018

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Crossref

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Transforming growth factor beta (TGF-beta) expression in isolated and cultured rat hepatocytes

21 January 2018

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12 December 2020

Compromised lymphocytes infiltrate hepatocellular carcinoma: the role of T-regulatory cells

1 reference

12 December 2020

Characterization of immunodeficiency in a patient with growth hormone insensitivity secondary to a novel STAT5b gene mutation

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12 December 2020

Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration

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12 December 2020

Growth hormone insensitivity associated with a STAT5b mutation

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20080003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19332876%20AND%20SRC:MED&resulttype=core&format=json

release_3fmyi2bdyzauti6dci47f5tqhy

25 January 2020

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/3fmyi2bdyzauti6dci47f5tqhy

24 November 2022

mapped directly with Wikidata item

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19332876%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference