The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients (Q37309561)

19 August 2017

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title

The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients (English)

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19 August 2017

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Alfred Ayala

3

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author name string

Nicholas S Ward

series ordinal

1

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PMCID

2786900

19 August 2017

Brian Casserly

series ordinal

2

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19 August 2017

1 December 2008

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Clinics in Chest Medicine

19 August 2017

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19 August 2017

29

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19 August 2017

617-25, viii

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19 August 2017

4

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Anti-inflammatory response is associated with mortality and severity of infection in sepsis.

19 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Polymicrobial sepsis induces divergent effects on splenic and peritoneal dendritic cell function in mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Sepsis syndromes: understanding the role of innate and acquired immunity.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Anti-inflammatory therapies in sepsis and septic shock

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Prevention of lymphocyte cell death in sepsis improves survival in mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Distinct mechanisms of immunosuppression as a consequence of major surgery

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Interleukin 10 protects mice from lethal endotoxemia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Changes in lymphocyte activity after thermal injury. The role of suppressor cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Post-traumatic immunosuppression is due to activation of suppressor T cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Host Resistance in Sepsis and Trauma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Delayed hypersensitivity: indicator of acquired failure of host defenses in sepsis and trauma

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Monocyte deactivation--rationale for a new therapeutic strategy in sepsis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

The compensatory anti-inflammatory cytokine interleukin 10 response in pediatric sepsis-induced multiple organ failure.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Low HLA-DR expression on monocytes as a prognostic marker for bacterial sepsis after liver transplantation

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Interferon gamma-1b in the treatment of compensatory anti-inflammatory response syndrome. A new approach: proof of principle.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

IL-1 and tumor necrosis factor-alpha each up-regulate both the expression of IFN-gamma receptors and enhance IFN-gamma-induced HLA-DR expression on human monocytes and a human monocytic cell line (THP-1).

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Defective IL-2 production in patients with severe burns and sepsis

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Enhancement of dendritic cell production by fms-like tyrosine kinase-3 ligand increases the resistance of mice to a burn wound infection

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Plasma cytokine levels predict mortality in patients with acute renal failure.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Predictive value of interleukins 6, 8 and 10, and low HLA-DR expression in acute renal failure.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Interaction between the innate and adaptive immune systems is required to survive sepsis and control inflammation after injury.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Predictive value of monocyte histocompatibility leukocyte antigen-DR expression and plasma interleukin-4 and -10 levels in critically ill patients with sepsis.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

HLA-DR as a marker for increased risk for systemic inflammation and septic complications after cardiac surgery.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Immunoparalysis in patients with severe trauma and the effect of inhaled interferon-gamma.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Interleukin-10: A complex role in the pathogenesis of sepsis syndromes and its potential as an anti-inflammatory drug.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Immunological monitoring of the inflammatory process: Which variables? When to assess?

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Dehydroepiandrosterone: an inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhage.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Anti-inflammatory cytokine profile and mortality in febrile patients.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Both T-helper-1- and T-helper-2-type lymphokines are depressed in posttrauma anergy.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Effects of IL-10 on systemic inflammatory responses during sublethal primate endotoxemia.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Negative signaling contributes to T-cell anergy in trauma patients

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786900

Hemorrhage without tissue trauma produces immunosuppression and enhances susceptibility to sepsis

20 October 2018

1 reference

12 December 2020

[Study on monocyte HLA-DR expression in critically ill patients after surgery]

1 reference

12 December 2020

DEHYDROEPIANDROSTERONE RESTORES IMMUNE FUNCTION FOLLOWING TRAUMA-HAEMORRHAGE BY A DIRECT EFFECT ON T LYMPHOCYTES

1 reference

12 December 2020

The effects of hemorrhage on mitogen-induced lymphocyte proliferation

1 reference

12 December 2020

Prediction of sepsis in the multitraumatic patient by assays of lymphocyte responsiveness

1 reference

12 December 2020

Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans

1 reference

12 December 2020

Interferon-gamma treatment increases HLA-DR expression on monocytes in severely injured patients

1 reference

12 December 2020

What is the role of interleukin 10 in polymicrobial sepsis: anti-inflammatory agent or immunosuppressant?

1 reference

12 December 2020

Granulocyte-macrophage colony-stimulating factor and IFN-gamma restore the systemic TNF-alpha response to endotoxin in lipopolysaccharide-desensitized mice

1 reference

12 December 2020

Exogenous interleukin-10 fails to decrease the mortality or morbidity of sepsis

1 reference

12 December 2020

Selective defects of T lymphocyte function in patients with lethal intraabdominal infection

1 reference

12 December 2020

Immunosuppressive effects of apoptotic cells

1 reference

12 December 2020

Increased mucosal B-lymphocyte apoptosis during polymicrobial sepsis is a Fas ligand but not an endotoxin-mediated process

1 reference

12 December 2020

Sir Isaac Newton, sepsis, SIRS, and CARS

1 reference

12 December 2020

Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome

1 reference

12 December 2020

Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction

1 reference

12 December 2020

Depletion of dendritic cells, but not macrophages, in patients with sepsis

1 reference

12 December 2020

Is low monocyte HLA-DR expression helpful to predict outcome in severe sepsis?

1 reference

12 December 2020

IL-10, a novel growth cofactor for mature and immature T cells

1 reference

12 December 2020

Monocyte response to bacterial toxins, expression of cell surface receptors, and release of anti-inflammatory cytokines during sepsis

1 reference

12 December 2020

Changes in T lymphocyte subsets following injury. Assessment by flow cytometry and relationship to sepsis

1 reference

12 December 2020

[Clinical value of monitoring CD14+ monocyte human leukocyte antigen (locus) DR levels in the early stage of sepsis]

1 reference

12 December 2020

Decrease in circulating dendritic cells predicts fatal outcome in septic shock

1 reference

12 December 2020

Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway

1 reference

12 December 2020

IL-10 is a major mediator of sepsis-induced impairment in lung antibacterial host defense

1 reference

12 December 2020

Anergy, immunosuppressive serum, and impaired lymphocyte blastogenesis in burn patients

1 reference

12 December 2020

Injury-induced suppression of effector T cell immunity requires CD1d-positive APCs and CD1d-restricted NKT cells

1 reference

12 December 2020

Regulatory dendritic cells act as regulators of acute lethal systemic inflammatory response

1 reference

12 December 2020

Monitoring of immunotherapy by measuring monocyte HLA-DR expression and stimulated TNFalpha production during sepsis after liver transplantation

1 reference

12 December 2020

Monocyte deactivation in septic patients: restoration by IFN-gamma treatment

1 reference

12 December 2020

Very low monocytic HLA-DR expression indicates high risk of infection--immunomonitoring for patients after neurosurgery and patients during high dose steroid therapy

1 reference

12 December 2020

Testosterone receptor blockade after hemorrhage in males. Restoration of the depressed immune functions and improved survival following subsequent sepsis

1 reference

12 December 2020

Dendritic cells during polymicrobial sepsis rapidly mature but fail to initiate a protective Th1-type immune response

1 reference

12 December 2020

Low HLA-DR expression on peripheral blood monocytes predicts bacterial sepsis after liver transplantation: relation with prednisolone intake

1 reference

12 December 2020

Early postoperative monocyte deactivation predicts systemic inflammation and prolonged stay in pediatric cardiac intensive care

1 reference

12 December 2020

Insights into the role of gammadelta T lymphocytes in the immunopathogenic response to thermal injury

1 reference

12 December 2020

Evaluation of lymphocyte reactivity studies in patients with thermal burns

1 reference

12 December 2020

Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10

1 reference

12 December 2020

The potential pattern of circulating lymphocytes TH1/TH2 is not altered after multiple injuries

1 reference

12 December 2020

Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection

1 reference

12 December 2020

Is the measurement of monocytes HLA-DR expression useful in patients with sepsis?

1 reference

12 December 2020

10.1016/J.CCM.2008.06.010

Identifiers

DOI

1 reference

19 August 2017

1 reference

19 August 2017

1 reference

PMCID

2786900