Triptolide-mediated inhibition of interferon signaling enhances vesicular stomatitis virus-based oncolysis (Q37316872)

19 August 2017

Triptolide-mediated inhibition of interferon signaling enhances vesicular stomatitis virus-based oncolysis (English)

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19 August 2017

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7

John Hiscott

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19 August 2017

8

Rongtuan Lin

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19 August 2017

6

David F Stojdl

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19 August 2017

Fethia Ben Yebdri

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19 August 2017

Julien Van Grevenynghe

2

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19 August 2017

Vera A Tang

3

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19 August 2017

Marie-Line Goulet

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19 August 2017

Jian Hui Wu

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19 August 2017

28 August 2013

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19 August 2017

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19 August 2017

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19 August 2017

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19 August 2017

2043-2053

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describes a project that uses

19 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3831042/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Oncolytic virotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms

9 September 2017

1 reference

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Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II).

9 September 2017

1 reference

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Inhibiting eukaryotic transcription: Which compound to choose? How to evaluate its activity?

9 September 2017

1 reference

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MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML

9 September 2017

1 reference

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Tripterygium wilfordii bioactive compounds as anticancer and anti-inflammatory agents.

9 September 2017

1 reference

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Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK).

9 September 2017

1 reference

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XPB, a subunit of TFIIH, is a target of the natural product triptolide.

9 September 2017

1 reference

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Triptolide and its expanding multiple pharmacological functions

9 September 2017

1 reference

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VSV oncolysis in combination with the BCL-2 inhibitor obatoclax overcomes apoptosis resistance in chronic lymphocytic leukemia

9 September 2017

1 reference

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MyD88-dependent and independent pathways of Toll-Like Receptors are engaged in biological activity of Triptolide in ligand-stimulated macrophages

9 September 2017

1 reference

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Synergistic interaction between oncolytic viruses augments tumor killing

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

RNA polymerase - an important molecular target of triptolide in cancer cells

9 September 2017

1 reference

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"Buy one get one free": armed viruses for the treatment of cancer cells and their microenvironment

9 September 2017

1 reference

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The case of oncolytic viruses versus the immune system: waiting on the judgment of Solomon

9 September 2017

1 reference

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Effects of triptolide from Radix Tripterygium wilfordii (Leigongteng) on cartilage cytokines and transcription factor NF-kappaB: a study on induced arthritis in rats

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Early steps of the virus replication cycle are inhibited in prostate cancer cells resistant to oncolytic vesicular stomatitis virus

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis.

9 September 2017

1 reference

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Targeting the apoptotic pathway with BCL-2 inhibitors sensitizes primary chronic lymphocytic leukemia cells to vesicular stomatitis virus-induced oncolysis

9 September 2017

1 reference

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Extracellular ATP and cancer: an overview with special reference to P2 purinergic receptors.

9 September 2017

1 reference

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VSV-tumor selective replication and protein translation

9 September 2017

1 reference

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Sensitivity of prostate tumors to wild type and M protein mutant vesicular stomatitis viruses

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Vesicular stomatitis virus: re-inventing the bullet

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Triptolide inhibits the differentiation of Th17 cells and suppresses collagen-induced arthritis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Triptolide inhibits Jak2 transcription and induces apoptosis in human myeloproliferative disorder cells bearing Jak2V617F through caspase-3-mediated cleavage of Mcl-1.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Triptolide induces apoptosis in human anaplastic thyroid carcinoma cells by a p53-independent but NF-kappaB-related mechanism.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

VSV virotherapy improves chemotherapy by triggering apoptosis due to proteasomal degradation of Mcl-1.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

The RAS/Raf1/MEK/ERK signaling pathway facilitates VSV-mediated oncolysis: implication for the defective interferon response in cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Extracellular ATP induces apoptotic signaling in human monocyte leukemic cells, HL-60 and F-36P.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Triptolide inhibits the growth and metastasis of solid tumors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

A potential new treatment for rheumatoid arthritis: thunder god vine

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Enhancing VSV oncolytic activity with an improved cytosine deaminase suicide gene strategy.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

The suppressive effect of triptolide on chronic colitis and TNF-alpha/TNFR2 signal pathway in interleukin-10 deficient mice

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Triptolide attenuates oxidative stress, NF-kappaB activation and multiple cytokine gene expression in murine peritoneal macrophage.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Triptolide inhibits transcription factor NF-kappaB and induces apoptosis of multiple myeloma cells

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

The suppressive effect of triptolide on experimental autoimmune uveoretinitis by down-regulating Th1-type response

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3831042

Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23985699

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Phase I dose-escalation study of F60008, a novel apoptosis inducer, in patients with advanced solid tumours

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23985699

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/MT.2013.187

1 reference

19 August 2017

1 reference

19 August 2017

PubMed publication ID

23985699

1 reference