Activated B cells in autoimmune diseases: the case for a regulatory role (Q37335863)

19 August 2017

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title

Activated B cells in autoimmune diseases: the case for a regulatory role (English)

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19 August 2017

2

Simon Fillatreau

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author name string

Stephen M Anderton

series ordinal

1

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19 August 2017

1 December 2008

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Nature Clinical Practice Rheumatology

19 August 2017

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19 August 2017

4

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19 August 2017

12

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19 August 2017

657-666

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Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis

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Exacerbation of ulcerative colitis after rituximab salvage therapy

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Worsening after rituximab treatment in anti-mag neuropathy

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B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice

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Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling

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Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice

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Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice

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B cells regulate autoimmunity by provision of IL-10.

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B cells limit epitope spreading and reduce severity of EAE induced with PLP peptide in BALB/c mice

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Prevention of arthritis by interleukin 10-producing B cells

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Distinct profiles of human B cell effector cytokines: a role in immune regulation?

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Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis.

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Regulatory role of mature B cells in a murine model of inflammatory bowel disease.

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Tolerance induction by gene transfer to lymphocytes

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Not always the bad guys: B cells as regulators of autoimmune pathology

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TLR-activated B cells suppress T cell-mediated autoimmunity

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TLR-mediated stimulation of APC: Distinct cytokine responses of B cells and dendritic cells.

21 January 2018

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Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis

21 January 2018

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The effect of infections on susceptibility to autoimmune and allergic diseases

21 January 2018

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Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice

21 January 2018

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Role of membrane immunoglobulin (Ig) crosslinking in membrane Ig-mediated, major histocompatibility-restricted T cell-B cell cooperation

21 January 2018

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Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens

21 January 2018

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Targeting autoantigen to B cells prevents the induction of a cell-mediated autoimmune disease in rats

21 January 2018

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Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells: evidence that the protective mechanism depends on changes in the cytokine response and migratory properties of the autoantigen-specific T cells

21 January 2018

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B cells turn off virgin but not memory T cells

21 January 2018

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A gene therapy approach for treating T-cell-mediated autoimmune diseases

21 January 2018

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Gene therapeutic approaches to induction and maintenance of tolerance

21 January 2018

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Epitope-specific tolerance induction with an engineered immunoglobulin

21 January 2018

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Haptens bound to self IgG induce immunologic tolerance, while when coupled to syngeneic spleen cells they induce immune suppression

21 January 2018

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Induction of hyporesponsiveness to intact foreign protein via retroviral-mediated gene expression: the IgG scaffold is important for induction and maintenance of immune hyporesponsiveness

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Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

21 January 2018

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Gene transfer of Ig-fusion proteins into B cells prevents and treats autoimmune diseases

21 January 2018

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Complete protection from relapsing experimental autoimmune encephalomyelitis induced by syngeneic B cells expressing the autoantigen.

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Tolerance induction via a B-cell delivered gene therapy-based protocol: optimization and role of the Ig scaffold

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A Theory of Self-Nonself Discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively

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Approaching the asymptote? Evolution and revolution in immunology

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

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Activation of human dendritic cells through CD40 cross-linking.

21 January 2018

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B lymphocytes regulate dendritic cell (DC) function in vivo: increased interleukin 12 production by DCs from B cell-deficient mice results in T helper cell type 1 deviation

21 January 2018

1 reference

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An innate cell-mediated, murine ulcerative colitis-like syndrome in the absence of nuclear factor of activated T cells.

21 January 2018

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Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice

21 January 2018

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Response to B-cell depleting therapy with rituximab reverts the abnormalities of T-cell subsets in patients with idiopathic thrombocytopenic purpura

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Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients

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Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells

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CD8+ T regulatory cells use a novel genetic program that includes CD103 to suppress Th1 immunity in eye-derived tolerance.

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The specific regulation of immune responses by CD8+ T cells restricted by the MHC class Ib molecule, Qa-1.

21 January 2018

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Integration of B cells and CD8+ T in the protective regulation of systemic epithelial inflammation

21 January 2018

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Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets

21 January 2018

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Retroviral delivery of GAD-IgG fusion construct induces tolerance and modulates diabetes: a role for CD4+ regulatory T cells and TGF-beta?

21 January 2018

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Treatment of diabetes in NOD mice by gene transfer of Ig-fusion proteins into B cells: role of T regulatory cells

21 January 2018

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Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis

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Epstein-Barr virus vector-mediated gene transfer into human B cells: potential for antitumor vaccination

21 January 2018

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Efficient nucleofection of primary human B cells and B-CLL cells induces apoptosis, which depends on the microenvironment and on the structure of transfected nucleic acids

21 January 2018

1 reference

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Mechanisms of gene therapy for tolerance: B7 signaling is required for peptide-IgG gene-transferred tolerance induction

21 January 2018

1 reference

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Mechanisms of tolerance induction by a gene-transferred peptide-IgG fusion protein expressed in B lineage cells

21 January 2018

1 reference

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Control of B-cell responses by Toll-like receptors

21 January 2018

1 reference

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Rituximab in the treatment of polyneuropathy associated with anti-MAG antibodies

21 January 2018

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Relapses After Treatment With Rituximab in a Patient With Multiple Sclerosis and Anti–Myelin-Associated Glycoprotein Polyneuropathy

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Ulcerative colitis following B lymphocyte depletion with rituximab in a patient with Graves' disease

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B cell-deficient mice do not develop type II collagen-induced arthritis (CIA)

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B cells are critical to induction of experimental allergic encephalomyelitis by protein but not by a short encephalitogenic peptide

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Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice

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Depletion of B cells in murine lupus: efficacy and resistance

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Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation

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Intravenous transfusion of BCR-activated B cells protects NOD mice from type 1 diabetes in an IL-10-dependent manner

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Regulatory role of B-1 B cells in chronic colitis

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Tolerance, danger, and the extended family

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Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

1 reference

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Activated B cells express functional Fas ligand

1 reference

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B cells activated by lipopolysaccharide, but not by anti-Ig and anti-CD40 antibody, induce anergy in CD8+ T cells: role of TGF-beta 1

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Induction of peripheral T cell tolerance by antigen-presenting B cells. II. Chronic antigen presentation overrules antigen-presenting B cell activation

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Characterization of Dendritic Cells that Induce Tolerance and T Regulatory 1 Cell Differentiation In Vivo

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Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen

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Peripheral tolerance via the anterior chamber of the eye: role of B cells in MHC class I and II antigen presentation

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Ocular immune privilege promoted by the presentation of peptide on tolerogenic B cells in the spleen. II. Evidence for presentation by Qa-1

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Essential role of CD8+CD122+ regulatory T cells in the recovery from experimental autoimmune encephalomyelitis

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B cell regulation of CD4+CD25+ T regulatory cells and IL-10 via B7 is essential for recovery from experimental autoimmune encephalomyelitis

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Experimental autoimmune encephalomyelitis induction in naive mice by dendritic cells presenting a self-peptide

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A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells

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Identifiers

DOI

10.1038/NCPRHEUM0950

1 reference

19 August 2017

1 reference

PubMed ID

19037227