Orexigenic hormone ghrelin ameliorates gut barrier dysfunction in sepsis in rats (Q37344288)

19 August 2017

Orexigenic hormone ghrelin ameliorates gut barrier dysfunction in sepsis in rats (English)

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19 August 2017

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Rongqian Wu

1

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Haichao Wang

object named as

Haichao Wang

4

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author name string

Weifeng Dong

2

1 reference

19 August 2017

Xiaoling Qiang

3

1 reference

19 August 2017

Steven A Blau

5

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19 August 2017

Thanjavur S Ravikumar

6

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19 August 2017

Ping Wang

7

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19 August 2017

language of work or name

English

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publication date

1 August 2009

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19 August 2017

Critical Care Medicine

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19 August 2017

37

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19 August 2017

8

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19 August 2017

2421-2426

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Orexigenic hormone ghrelin attenuates local and remote organ injury after intestinal ischemia-reperfusion

19 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Sepsis: time to reconsider the concept

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Novel connections between the neuroendocrine and immune systems: the ghrelin immunoregulatory network

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Ghrelin inhibits sympathetic nervous activity in sepsis.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Ghrelin attenuates sepsis-induced acute lung injury and mortality in rats

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

The fundamental basis of inflammatory bowel disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Ghrelin controls hippocampal spine synapse density and memory performance

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Burns, bacterial translocation, gut barrier function, and failure

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Ghrelin: structure and function

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Role of the gastrointestinal tract in burn sepsis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Reversing established sepsis with antagonists of endogenous high-mobility group box 1.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Structural basis for the proinflammatory cytokine activity of high mobility group box 1

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

6 September 2017

The inflammatory reflex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Pharmacological stimulation of the cholinergic antiinflammatory pathway

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Ghrelin--not just another stomach hormone

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

HMG-1 as a late mediator of endotoxin lethality in mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Inhibition of endotoxin-induced bacterial translocation in mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Central ghrelin gastroprotection involves nitric oxide/prostaglandin cross-talk

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Effect of critical illness on microbial translocation and gastrointestinal mucosa permeability.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Role of the gut in multiple organ failure: bacterial translocation and permeability changes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Nitric oxide directly impairs intestinal barrier function.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Upwardly mobile proteins. Workshop: the role of HMG proteins in chromatin structure, gene expression and neoplasia

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Glutamine depletion and increased gut permeability in nonanorectic, non-weight-losing tumor-bearing rats.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Specific recognition of cruciform DNA by nuclear protein HMG1.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Pathophysiology of LPS-induced gastrointestinal injury in the rat: role of secretory phospholipase A2.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

In vivo and in vitro antioxidant activity of ghrelin: Attenuation of gastric ischemic injury in the rat.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Ghrelin improves tissue perfusion in severe sepsis via downregulation of endothelin-1.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Ghrelin--satisfying a hunger for the mechanism

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Increased iNOS activity is essential for intestinal epithelial tight junction dysfunction in endotoxemic mice

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Ghrelin clearance is reduced at the late stage of polymicrobial sepsis

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Growth hormone secretagogue receptor expression in the cells of the stomach-projected afferent nerve in the rat nodose ganglion

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Inducible nitric oxide synthase knockout mice are resistant to diet-induced loss of gut barrier function and intestinal injury.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Growth hormone secretagogue binding sites in peripheral human tissues.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742951

Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock*

2 September 2018

1 reference

12 December 2020

HMGB1 is secreted by immunostimulated enterocytes and contributes to cytomix-induced hyperpermeability of Caco-2 monolayers

1 reference

12 December 2020

Ghrelin protects against experimental sepsis by inhibiting high-mobility group box 1 release and by killing bacteria

1 reference

12 December 2020

Ghrelin down-regulates proinflammatory cytokines in sepsis through activation of the vagus nerve

1 reference

12 December 2020

Cytokine-induced intestinal epithelial hyperpermeability: role of nitric oxide

1 reference

12 December 2020

Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation

1 reference

12 December 2020

Generation of polyclonal antiserum against the growth hormone secretagogue receptor (GHS-R): evidence that the GHS-R exists in the hypothalamus, pituitary and stomach of rats

1 reference

12 December 2020

Inhibition of inducible nitric oxide synthase ameliorates endotoxin-induced gut mucosal barrier dysfunction in rats

1 reference

12 December 2020

Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients

1 reference

12 December 2020

10.1097/CCM.0B013E3181A557A2

Identifiers

DOI

1 reference

19 August 2017

1 reference

19 August 2017

PubMed publication ID

19531942

1 reference