IL-21 comes of age as a regulator of effector T cells in the gut. (Q37349709)

19 August 2017

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title

IL-21 comes of age as a regulator of effector T cells in the gut. (English)

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19 August 2017

M C Fantini

1

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19 August 2017

G Monteleone

series ordinal

2

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19 August 2017

T T MacDonald

series ordinal

3

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19 August 2017

23 January 2008

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19 August 2017

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19 August 2017

1

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19 August 2017

2

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19 August 2017

110-115

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https://scigraph.springernature.com/pub.10.1038/mi.2007.17

19 August 2017

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cites work

Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

Emerging drugs to treat Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Anti-interleukin-12 antibody for active Crohn's disease

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease.

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

CD4+ T-cell population mediates development of inflammatory bowel disease in T-cell receptor alpha chain-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Divergent cell cycle kinetics underlie the distinct functional capacity of mucosal T cells in Crohn's disease and ulcerative colitis.

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

The IL-23/IL-17 axis in inflammation

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Antibodies to interleukin 12 abrogate established experimental colitis in mice

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Interleukin-21 inhibits dendritic cell activation and maturation

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Interleukin-21 inhibits dendritic cell-mediated T cell activation and induction of contact hypersensitivity in vivo

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

A critical role for IL-21 in regulating immunoglobulin production

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

The IL-21 receptor augments Th2 effector function and alternative macrophage activation

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Transforming growth factor-beta induces development of the T(H)17 lineage

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Cutting Edge: Trans-Signaling via the Soluble IL-6R Abrogates the Induction of FoxP3 in Naive CD4+CD25- T Cells

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Monoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in Mice

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Increased expression of interleukin 17 in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells.

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

A Functional Role for Interleukin-21 in Promoting the Synthesis of the T-Cell Chemoattractant, MIP-3α, by Gut Epithelial Cells

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Phenotypic and functional features of human Th17 cells

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21.

1 reference

https://api.crossref.org/works/10.1038%2FMI.2007.17

7 January 2021

Identifiers

DOI

10.1038/MI.2007.17

1 reference

Dimensions Publication ID

19 August 2017

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