Genetic models of cancer in zebrafish (Q37350419)

19 August 2017

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title

Genetic models of cancer in zebrafish (English)

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19 August 2017

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2

E Elizabeth Patton

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19 August 2017

James F Amatruda

1

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19 August 2017

1 January 2008

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International Review of Cell and Molecular Biology

19 August 2017

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19 August 2017

271

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19 August 2017

1-34

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Exploiting the convergence of embryonic and tumorigenic signaling pathways to develop new therapeutic targets

19 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Zebrafish as a cancer model system

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

A large-scale insertional mutagenesis screen in zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Identification of 315 genes essential for early zebrafish development

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Contributions of the Gordon-Kosswig melanoma system to the present concept of neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

High-frequency developmental abnormalities in p53-deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Dual inactivation of RB and p53 pathways in RAS-induced melanomas

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Making waves in cancer research: new models in the zebrafish.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Efficient gene targeting in Drosophila with zinc-finger nucleases

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

p53 from complexity to simplicity: mutant p53 stabilization, gain-of-function, and dominant-negative effect

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

p53 and its isoforms in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Dissection of angiogenic signaling in zebrafish using a chemical genetic approach

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

NOTCH1-induced T-cell leukemia in transgenic zebrafish.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Liver-specific expression of p53-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Malignant melanoma: genetics and therapeutics in the genomic era.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Size control goes global

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Ptena and ptenb genes play distinct roles in zebrafish embryogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

The 'definitive' (and 'primitive') guide to zebrafish hematopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Mutations of the BRAF gene in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

MAP kinase signalling pathways in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

The multiple roles of PTEN in tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Zebrafish in the wild: a review of natural history and new notes from the field

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Homologous recombination in zebrafish ES cells

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Zebrafish pten genes have overlapping and non-redundant functions in tumorigenesis and embryonic development.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

The APC gene in colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Classic and novel roles of p53: prospects for anticancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Temozolomide-mediated radiosensitization of human glioma cells in a zebrafish embryonic system

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

New waves of discovery: modeling cancer in zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Fishing for cancer models

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Melanoma biology and new targeted therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Headwaters of the zebrafish -- emergence of a new model vertebrate

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Reprogramming metastatic tumour cells with embryonic microenvironments

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

The Wnt/beta-catenin pathway regulates cardiac valve formation

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

p53 biological network: at the crossroads of the cellular-stress response pathway and molecular carcinogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Lessons from the p53 mutant mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Tumor spectrum analysis in p53-mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Transposon tools and methods in zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Localization of a CDKN2 gene in linkage group V of Xiphophorus fishes defines it as a candidate for the DIFF tumor suppressor.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Colorectal polyps and their relationship to cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

The zebrafish mutants dre, uki, and lep encode negative regulators of the hedgehog signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

The Tol2kit: a multisite gateway-based construction kit for Tol2 transposon transgenesis constructs

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Modeling liver cancer using zebrafish: a comparative oncogenomics approach

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Myc-induced T cell leukemia in transgenic zebrafish.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Effects of RAS on the genesis of embryonal rhabdomyosarcoma.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Embryogenesis meets tumorigenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

The fate of human malignant melanoma cells transplanted into zebrafish embryos: assessment of migration and cell division in the absence of tumor formation.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Detection of the p53 response in zebrafish embryos using new monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

CXCR4/CXCL12 axis promotes VEGF-mediated tumor angiogenesis through Akt signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Lessons from p53 in non-mammalian models.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Medulloblastoma: developmental mechanisms out of control

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

From Mendelian to molecular genetics: the Xiphophorus melanoma model

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

The Clinical Diagnosis, Classification and Histogenetic Concepts of the Early Stages of Cutaneous Malignant Melanomas

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Transplantable tumor lines generated in clonal zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Zebrafish genomic instability mutants and cancer susceptibility.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

A chemical genetic screen for cell cycle inhibitors in zebrafish embryos

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

A CDKN2-like polymorphism in Xiphophorus LG V is associated with UV-B-induced melanoma formation in platyfish-swordtail hybrids

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

The zebrafish/tumor xenograft angiogenesis assay.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Mammalian tumor xenografts induce neovascularization in zebrafish embryos

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Modeling human hematopoietic and cardiovascular diseases in zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Hematopoietic perturbation in zebrafish expressing a tel-jak2a fusion.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

The art and design of genetic screens: zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

High frequency of BRAF mutations in nevi

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Chimeric nucleases stimulate gene targeting in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Wnt signaling in the stem cell niche

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Wnt signalling in stem cells and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

p53 activation by knockdown technologies

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Medulloblastoma: a problem of developmental biology

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Does the ribosome translate cancer?

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

MEK inhibitors: a therapeutic approach to targeting the Ras-MAP kinase pathway in tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Animal model for ultraviolet radiation-induced melanoma: platyfish-swordtail hybrid

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

The INK4a/ARF locus and melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

A mutation in separase causes genome instability and increased susceptibility to epithelial cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Neoplasia in zebrafish (Danio rerio) treated with 7,12-dimethylbenz[a]anthracene by two exposure routes at different developmental stages.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Neoplasia in zebrafish (Danio rerio) treated with N-methyl-N'-nitro-N-nitrosoguanidine by three exposure routes at different developmental stages.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

DIETHYLNITROSAMINE-INDUCED HEPATIC DEGENERATION AND NEOPLASIA IN THE AQUARIUM FISH, BRACHYDANIO RERIO

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Cancer genetics and drug discovery in the zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Small molecules that delay S phase suppress a zebrafish bmyb mutant

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

High-resolution imaging of the dynamic tumor cell vascular interface in transparent zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Production of clones of homozygous diploid zebra fish (Brachydanio rerio)

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Clonal origins of cells in the pigmented retina of the zebrafish eye.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

The Mdm2 gene of zebrafish (Danio rerio): preferential expression during development of neural and muscular tissues, and absence of tumor formation after overexpression of its cDNA during early embryogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

VEGF is upregulated by hypoxia-induced mitogenic factor via the PI-3K/Akt-NF-kappaB signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

The use of zebrafish to understand immunity

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

p53 in health and disease

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Pathways to melanoma development: lessons from the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Intestinal growth and differentiation in zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Xiphophorus interspecies hybrids as genetic models of induced neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Transparent adult zebrafish as a tool for in vivo transplantation analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Efficient target-selected mutagenesis in zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

The Xmrk receptor tyrosine kinase is activated in Xiphophorus malignant melanoma.

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Targeted expression of human MYCN selectively causes pancreatic neuroendocrine tumors in transgenic zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

Cancer phenomics: RET and PTEN as illustrative models

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

In vivo drug discovery in the zebrafish

1 reference

https://api.crossref.org/works/10.1016%2FS1937-6448%2808%2901201-X

7 January 2021

10.1016/S1937-6448(08)01201-X

Identifiers

DOI

1 reference

19 August 2017

1 reference

PubMed ID

19081540