Hyperproinsulinemia is associated with increased beta cell demand after hemipancreatectomy in humans (Q37350440)

19 August 2017

Hyperproinsulinemia is associated with increased beta cell demand after hemipancreatectomy in humans (English)

1 reference

19 August 2017

E R Seaquist

1

1 reference

19 August 2017

S E Kahn

2

1 reference

19 August 2017

P M Clark

3

1 reference

19 August 2017

C N Hales

4

1 reference

19 August 2017

D Porte

5

1 reference

19 August 2017

R P Robertson

6

1 reference

19 August 2017

language of work or name

English

0 references

publication date

1 January 1996

1 reference

Journal of Clinical Investigation

19 August 2017

1 reference

19 August 2017

97

1 reference

19 August 2017

455-460

1 reference

19 August 2017

2

1 reference

Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus

19 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Hyperproinsulinemia and amyloid in NIDDM. Clues to etiology of islet beta-cell dysfunction?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Banting lecture 1990. Beta-cells in type II diabetes mellitus

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Raised proinsulin concentration as early indicator of beta cell dysfunction

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Effects of hemipancreatectomy on pancreatic alpha and beta cell function in healthy human donors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

The histocompatibility system in juvenile, insulin-dependent diabetic multiplex kindreds

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

What beta-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Disproportionately elevated proinsulin in Pima Indians with noninsulin-dependent diabetes mellitus

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Inhibition of ATP-sensitive K+ channels in pancreatic beta-cells by nonsulfonylurea drug linogliride

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Effect of glucocorticoid and growth hormone treatment on proinsulin levels in humans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Direct measurement of plasma proinsulin in normal and diabetic subjects

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Circulating proinsulin-like component in man: increased proportion in hypoinsulinemic states.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

A sensitive radioimmunoassay for human proinsulin, with sequential use of antisera to C-peptide and insulin.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Reduction of glycemic potentiation. Sensitive indicator of beta-cell loss in partially pancreatectomized dogs

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Increased proinsulin levels as an early indicator of B-cell dysfunction in non-diabetic twins of type 1 (insulin-dependent) diabetic patients.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Increased beta-cell secretory capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Effects of hemipancreatectomy on insulin secretion and glucose tolerance in healthy humans.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Plasma proinsulin in first-degree relatives of type 2 diabetic subjects.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Hyperinsulinaemia in obesity is not accompanied by an increase in serum proinsulin/insulin ratio in groups of human subjects with and without glucose intolerance.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Glucose-induced Insulin Response is Reduced and Proinsulin Response Increased in Healthy Siblings of Type 1 Diabetic Patients

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Elevated proinsulin levels related to islet cell antibodies in first-degree relatives of IDDM patients.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Potentiation of Insulin Secretory Responses by Plasma Glucose Levels in Man: Evidence That Hyperglycemia in Diabetes Compensates for Impaired Glucose Potentiation*

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Proinsulin and specific insulin concentration in high- and low-risk populations for NIDDM.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Proinsulin as a marker for the development of NIDDM in Japanese-American men.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Insulin-mediated and glucose-mediated glucose uptake following hemipancreatectomy in healthy human donors.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Hyperproinsulinemia of type II diabetes is not present before the development of hyperglycemia.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507037

Follow-Up of Women With Previous GDM: Insulin, C-Peptide, and Proinsulin Responses to Oral Glucose Load

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/8567967

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Islet cell and other organ-specific antibodies in U.S. Caucasians and Blacks with insulin-dependent diabetes mellitus

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/8567967

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pancreas transplantation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/8567967

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI118435

1 reference

19 August 2017

1 reference

19 August 2017

1 reference