The application of phosphoramidate protide technology to acyclovir confers anti-HIV inhibition. (Q37357285)

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4 February 2020

title

The application of phosphoramidate protide technology to acyclovir confers anti-HIV inhibition (English)

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4 February 2020

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4 February 2020

Andrea Brancale

3

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4 February 2020

Chris McGuigan

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4 February 2020

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Leonid Margolis

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4 February 2020

Christophe Vanpouille

4

object named as

Christophe Vanpouille

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4 February 2020

5

Andrea Lisco

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4 February 2020

author name string

Davide Carta

2

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4 February 2020

Jan Balzarini

7

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4 February 2020

language of work or name

English

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publication date

1 September 2009

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Journal of Medicinal Chemistry

4 February 2020

published in

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4 February 2020

volume

52

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4 February 2020

issue

17

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4 February 2020

page(s)

5520-5530

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Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues

4 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748767

Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency

6 September 2017

1 reference

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Aryloxy phosphoramidate triesters as pro-tides

6 September 2017

1 reference

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Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases

6 September 2017

1 reference

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Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748767

Carboxypeptidase Y: structural basis for protein sorting and catalytic triad

6 September 2017

1 reference

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2.8-A structure of yeast serine carboxypeptidase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748767

Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748767

Application of the phosphoramidate ProTide approach to 4'-azidouridine confers sub-micromolar potency versus hepatitis C virus on an inactive nucleoside.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748767

Naphthyl phosphoramidate derivatives of BVdU as potential anticancer agents: design, synthesis and biological evaluation.

14 September 2017

1 reference

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Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748767

Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748767

Successful kinase bypass with new acyclovir phosphoramidate prodrugs

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748767

Phosphorylation of acyclovir diphosphate by cellular enzymes

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19645484

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

1 reference

https://pubmed.ncbi.nlm.nih.gov/19645484

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM9007856

1 reference

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4 February 2020

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4 February 2020

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