Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera. (Q37360013)

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scientific article published on September 1996

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English	Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera.	scientific article published on September 1996

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scholarly article

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19 October 2019

Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera (English)

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19 October 2019

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ChEBI release 2020-05-28

Patrick Dansette

6

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19 October 2019

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M A Robin

1

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19 October 2019

M Maratrat

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19 October 2019

M Le Roy

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19 October 2019

F P Le Breton

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19 October 2019

E Bonierbale

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19 October 2019

F Ballet

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19 October 2019

D Mansuy

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19 October 2019

D Pessayre

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1 September 1996

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19 October 2019

Journal of Clinical Investigation

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19 October 2019

98

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19 October 2019

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19 October 2019

1471-1480

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19 October 2019

Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid

1 reference

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Decrease in hepatic cytochrome P-450 by cobalt. Evidence for a role of cobalt protoporphyrin

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A new anti-liver-kidney microsome antibody (anti-LKM2) in tienilic acid-induced hepatitis

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Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug

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Immune mechanisms in tienilic acid associated hepatotoxicity

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Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis.

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Interactions of colchicine with tubulin

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Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B

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Autoantibodies against cytochromes P450: role in human diseases

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Role of reactive metabolites in drug-induced hepatitis.

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Serum antibodies from halothane hepatitis patients react with the rat endoplasmic reticulum protein ERp72.

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The Cytoplasmic and N-terminal Transmembrane Domains of Cytochrome P450 Contain Independent Signals for Retention in the Endoplasmic Reticulum

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The time courses of intracellular transport of some secretory proteins of rat liver are not affected by an induced acute phase response.

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Effect of caffeine and reduced temperature (20 degrees C) on the organization of the pre-Golgi and the Golgi stack membranes

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Bile acid transport into hepatocyte smooth endoplasmic reticulum vesicles is mediated by microsomal epoxide hydrolase, a membrane protein exhibiting two distinct topological orientations.

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Association of anti-58 kDa endoplasmic reticulum antibodies with halothane hepatitis

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Immunological studies on the mechanism of halothane-induced hepatotoxicity: immunohistochemical evidence of trifluoroacetylated hepatocytes.

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Metabolic basis for a drug hypersensitivity: antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane

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Presence of covalently bound metabolites on rat hepatocyte plasma membrane proteins after administration of isaxonine, a drug leading to immunoallergic hepatitis in man.

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Detection of human hepatitis anti-liver kidney microsomes (LKM2) autoantibodies on rat liver sections is predominantly due to reactivity with rat liver P-450 IIC11

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Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity: comparison with two directly hepatotoxic drugs.

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Importance of the proline-rich region following signal-anchor sequence in the formation of correct conformation of microsomal cytochrome P-450s

1 reference

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based on heuristic

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Membrane topology of liver microsomal cytochrome P450 2B4 determined via monoclonal antibodies directed to the halt-transfer signal

1 reference

https://pubmed.ncbi.nlm.nih.gov/8823314

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of dihydralazine with cytochromes P4501A: a possible explanation for the appearance of anti-cytochrome P4501A2 autoantibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/8823314

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P4502B follows a vesicular route to the plasma membrane in cultured rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8823314

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interleukin-2 receptor down-regulates the expression of cytochrome P450 in cultured rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8823314

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence of functional cytochrome P-450 on isolated rat hepatocyte plasma membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/8823314

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochromes P-450 in human hepatocyte plasma membrane: recognition by several autoantibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/8823314

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-450 2C9 and 2C10

1 reference

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Proteolysis and lipid-facilitated translocation are distinct but competitive processes that regulate secretion of apolipoprotein B in Hep G2 cells

1 reference

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based on heuristic

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Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone

1 reference

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Identifiers

10.1172/JCI118936

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19 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8823314%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

1 reference

Europe PubMed Central

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19 October 2019

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