Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoforms of the IG20 gene (Q37383857)

20 August 2017

Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoforms of the IG20 gene (English)

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20 August 2017

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Liang Cheng Li

1

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20 August 2017

Jian Rong Sheng

2

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20 August 2017

Nirupama Mulherkar

3

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20 August 2017

Bellur S Prabhakar

4

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20 August 2017

Matthew N Meriggioli

5

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20 August 2017

language of work or name

English

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publication date

1 September 2008

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20 August 2017

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20 August 2017

68

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20 August 2017

18

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20 August 2017

7352-7361

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describes a project that uses

20 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2760438/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Alternative splicing: new insights from global analyses

6 September 2017

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Purification and properties of Rab3 GEP (DENN/MADD)

6 September 2017

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6 September 2017

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IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC

6 September 2017

1 reference

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Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons

6 September 2017

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IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs

6 September 2017

1 reference

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IG20, a MADD splice variant, increases cell susceptibility to gamma-irradiation and induces soluble mediators that suppress tumor cell growth

6 September 2017

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Inhibition of human immunodeficiency virus type 1 replication in primary macrophages by using Tat- or CCR5-specific small interfering RNAs expressed from a lentivirus vector

6 September 2017

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Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

6 September 2017

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Neuroblastoma: biological insights into a clinical enigma

6 September 2017

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A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses

6 September 2017

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A system for stable expression of short interfering RNAs in mammalian cells

6 September 2017

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Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3

6 September 2017

1 reference

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Aggressive childhood neuroblastomas do not express caspase-8: an important component of programmed cell death

6 September 2017

1 reference

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Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction

6 September 2017

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The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22

6 September 2017

1 reference

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A splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous system

6 September 2017

1 reference

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Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro

6 September 2017

1 reference

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MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase

6 September 2017

1 reference

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DENN, a novel human gene differentially expressed in normal and neoplastic cells

6 September 2017

1 reference

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An interferon-sensitive response element is involved in constitutive caspase-8 gene expression in neuroblastoma cells.

6 September 2017

1 reference

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MADD/DENN splice variant of the IG20 gene is necessary and sufficient for cancer cell survival

14 September 2017

1 reference

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Potentiation of neuroblastoma metastasis by loss of caspase-8.

14 September 2017

1 reference

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Drug-mediated sensitization to TRAIL-induced apoptosis in caspase-8-complemented neuroblastoma cells proceeds via activation of intrinsic and extrinsic pathways and caspase-dependent cleavage of XIAP, Bcl-xL and RIP.

14 September 2017

1 reference

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The death domain of Rab3 guanine nucleotide exchange protein in GDP/GTP exchange activity in living cells

14 September 2017

1 reference

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MADD/DENN splice variant of the IG20 gene is a negative regulator of caspase-8 activation. Knockdown enhances TRAIL-induced apoptosis of cancer cells.

28 September 2017

1 reference

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Induction of caspase 8 by interferon gamma renders some neuroblastoma (NB) cells sensitive to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) but reveals that a lack of membrane TR1/TR2 also contributes to TRAIL resistance in NB.

2 September 2018

1 reference

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IFNgamma sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway.

2 September 2018

1 reference

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Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer

2 September 2018

1 reference

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Role of IG20 splice variants in TRAIL resistance

2 September 2018

1 reference

12 December 2020

Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

1 reference

12 December 2020

Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis

1 reference

12 December 2020

Expression and methylation of CASP8 in neuroblastoma: identification of a promoter region

1 reference

12 December 2020

1 reference

12 December 2020

10.1158/0008-5472.CAN-07-6311

Identifiers

DOI

1 reference

20 August 2017

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20 August 2017

PubMed publication ID

18794122

1 reference