Eczema genetics: current state of knowledge and future goals (Q37390367)

20 August 2017

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title

Eczema genetics: current state of knowledge and future goals (English)

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20 August 2017

Sara J Brown

1

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author name string

W H Irwin McLean

series ordinal

2

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PubMed ID

19209157

20 August 2017

language of work or name

English

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publication date

1 March 2009

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Journal of Investigative Dermatology

20 August 2017

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20 August 2017

129

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20 August 2017

3

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20 August 2017

543-552

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https://scigraph.springernature.com/pub.10.1038/jid.2008.413

20 August 2017

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The immunogenetics of asthma and eczema: a new focus on the epithelium

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Caspase-14 reveals its secrets

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Stratum corneum tryptic enzyme in normal epidermis: a missing link in the desquamation process?

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Interactions among stratum corneum defensive functions

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Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population: a family and case-control study

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Single nucleotide polymorphism-based genome-wide linkage analysis in Japanese atopic dermatitis families

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Photoprotection: sunscreens and the immunomodulatory effects of UV irradiation

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Lack of association of SPINK5 polymorphisms with nonsyndromic atopic dermatitis in the population of Northern Germany

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R501X and 2282del4 Filaggrin Mutations Do Not Confer Susceptibility to Psoriasis and Atopic Dermatitis in Italian Patients

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Effect of phototherapy and urocanic acid isomers on natural killer cell function

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Filaggrin repeat number polymorphism is associated with a dry skin phenotype

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De Novo Occurrence of the Filaggrin Mutation p.R501X with Prevalent Mutation c.3321delA in a Japanese Family with Ichthyosis Vulgaris Complicated by Atopic Dermatitis

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Filaggrin mutations and allergic contact sensitization

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7 January 2021

Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children.

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7 January 2021

The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study

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7 January 2021

Atopic dermatitis with increased severity along a line of Blaschko

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7 January 2021

The genetics of atopic dermatitis: recent findings and future options.

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7 January 2021

Cytokine modulation of atopic dermatitis filaggrin skin expression

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Skin barrier function and allergic risk

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Percutaneous penetration of sodium lauryl sulphate is increased in uninvolved skin of patients with atopic dermatitis compared with control subjects

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Altered penetration of polyethylene glycols into uninvolved skin of atopic dermatitis patients

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7 January 2021

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7 January 2021

Association between polymorphisms in caspase recruitment domain containing protein 15 and allergy in two German populations

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7 January 2021

Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population

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7 January 2021

Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families

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7 January 2021

Loss-of-Function Mutations in the Filaggrin Gene Lead to Reduced Level of Natural Moisturizing Factor in the Stratum Corneum

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7 January 2021

Genetic susceptibility to atopic dermatitis

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7 January 2021

Elevated stratum corneum hydrolytic activity in Netherton syndrome suggests an inhibitory regulation of desquamation by SPINK5-derived peptides

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

A major susceptibility locus for atopic dermatitis maps to chromosome 3q21.

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Filaggrin null alleles are not associated with hand eczema or contact allergy

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

An IL13 coding region variant is associated with a high total serum IgE level and atopic dermatitis in the German multicenter atopy study (MAS-90)

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Interaction of filaggrin with keratin filaments during advanced stages of normal human epidermal differentiation and in ichthyosis vulgaris

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Association between genetic variants of mast-cell chymase and eczema

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march.

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Profilaggrin is a major epidermal calcium-binding protein

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

The role of toll-like receptors in the pathogenesis and treatment of dermatological disease

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

An action spectrum for the production of cis-urocanic acid in human skin in vivo

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Characterization and investigation of single nucleotide polymorphisms and a novel TLR2 mutation in the human TLR2 gene

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Genes encoding structural proteins of epidermal cornification and S100 calcium-binding proteins form a gene complex ("epidermal differentiation complex") on human chromosome 1q21

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Perinatal predictors of atopic dermatitis occurring in the first six months of life

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Investigation of the chromosome 17q25 PSORS2 locus in atopic dermatitis

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Filaggrin mutations in children with severe atopic dermatitis

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

The genetics of atopic dermatitis

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Cytogenetic and molecular evidence for cutaneous mosaicism: the ectodermal origin of Blaschko lines

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Association between polymorphisms in the SPINK5 gene and atopic dermatitis in the Japanese

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Specific Filaggrin Mutations Cause Ichthyosis Vulgaris and Are Significantly Associated with Atopic Dermatitis in Japan

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis

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7 January 2021

Immunosuppression by ultraviolet B radiation: initiation by urocanic acid

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7 January 2021

Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

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7 January 2021

Exploiting the proteome to improve the genome-wide genetic analysis of epistasis in common human diseases

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7 January 2021

Characterization of two distinct calcium-binding sites in the amino-terminus of human profilaggrin.

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Barrier function in transgenic mice overexpressing K16, involucrin, and filaggrin in the suprabasal epidermis

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Evidence for specific proteolytic cleavage of the N-terminal domain of human profilaggrin during epidermal differentiation

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7 January 2021

Moisturization and skin barrier function

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Global variation in copy number in the human genome

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Association of allergic contact dermatitis with a promoter polymorphism in the IL16 gene

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Filaggrin loss-of-function mutations and association with allergic diseases

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Filaggrin loss-of-function variant contributes to atopic dermatitis risk in the population of Northern Germany

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Much atopy about the skin: genome-wide molecular analysis of atopic eczema

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q.

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Prevalent and Rare Mutations in the Gene Encoding Filaggrin Cause Ichthyosis Vulgaris and Predispose Individuals to Atopic Dermatitis

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Sequence analysis of filaggrin gene by novel shotgun method in Japanese atopic dermatitis.

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Polysensitization and increased susceptibility in contact allergy: a review

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Genetics of nickel allergic contact dermatitis.

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Atopic dermatitis: a genetic-epidemiologic study in a population-based twin sample

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris.

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Linkage and association to candidate regions in Swedish atopic dermatitis families

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Two Common Loss-of-Function Mutations within the Filaggrin Gene Predispose for Early Onset of Atopic Dermatitis

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Relative impact of nucleotide and copy number variation on gene expression phenotypes

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Large-scale DNA microarray analysis of atopic skin lesions shows overexpression of an epidermal differentiation gene cluster in the alternative pathway and lack of protective gene expression in the cornified envelope

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Ichthyosis vulgaris: identification of a defect in synthesis of filaggrin correlated with an absence of keratohyaline granules

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Proceedings of the 4th Georg Rajka International Symposium on Atopic Dermatitis, Arcachon, France, September 15-17, 2005

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Importance of genetic factors in the etiology of atopic dermatitis: a twin study.

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Skin barrier disruption by sodium lauryl sulfate-exposure alters the expressions of involucrin, transglutaminase 1, profilaggrin, and kallikreins during the repair phase in human skin in vivo

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Absence of association between asthma and high serum immunoglobulin E associated GPRA haplotypes and adult atopic dermatitis

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Association of parental eczema, hayfever, and asthma with atopic dermatitis in infancy: birth cohort study.

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Gene polymorphism in Netherton and common atopic disease

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Association of CARD15 polymorphisms with atopy-related traits in a population-based cohort of Caucasian adults

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Association of NOD1 polymorphisms with atopic eczema and related phenotypes

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Lack of association between Toll-like receptor 2 and Toll-like receptor 4 polymorphisms and atopic eczema

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Filaggrin mutations, atopic eczema, hay fever, and asthma in children

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

N-acetyltransferase 1 and 2 polymorphisms in para-substituted arylamine-induced contact allergy

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Cytokine gene polymorphisms in allergic contact dermatitis

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

"Objective" measures of atopic dermatitis severity: in search of the holy Grail.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Two types of eczema--or are there?

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https://api.crossref.org/works/10.1038%2FJID.2008.413

7 January 2021

Identifiers

DOI

10.1038/JID.2008.413

1 reference

20 August 2017

1 reference

PubMed ID

19209157