Complement and microglia mediate early synapse loss in Alzheimer mouse models. (Q37391481)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27033548%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

title

Complement and microglia mediate early synapse loss in Alzheimer mouse models (English)

1 reference

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31 March 2020

0 references

0 references

Complement component 1, q subcomponent, alpha polypeptide

1 reference

Complement component 1, q subcomponent, beta polypeptide

GOA release 2020-03-11

1 reference

Complement component 1, q subcomponent, C chain

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Saranya Ramakrishnan

6

1 reference

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31 March 2020

12

Dennis J Selkoe

1 reference

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31 March 2020

10

Ben A Barres

1 reference

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31 March 2020

author name string

Soyon Hong

1

1 reference

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31 March 2020

Victoria F Beja-Glasser

2

1 reference

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31 March 2020

Bianca M Nfonoyim

3

1 reference

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31 March 2020

Arnaud Frouin

4

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31 March 2020

Shaomin Li

5

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31 March 2020

Katherine M Merry

7

1 reference

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31 March 2020

Qiaoqiao Shi

8

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31 March 2020

Arnon Rosenthal

9

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31 March 2020

Cynthia A Lemere

11

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31 March 2020

Beth Stevens

13

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31 March 2020

language of work or name

English

0 references

publication date

31 March 2016

1 reference

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31 March 2020

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31 March 2020

volume

352

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31 March 2020

issue

6286

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31 March 2020

page(s)

712-716

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New insights on the role of microglia in synaptic pruning in health and disease

31 March 2020

cites work

1 reference

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Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes

6 September 2017

1 reference

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Identification of a unique TGF-β-dependent molecular and functional signature in microglia

6 September 2017

1 reference

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TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement

6 September 2017

1 reference

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Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model

6 September 2017

1 reference

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A dramatic increase of C1q protein in the CNS during normal aging.

6 September 2017

1 reference

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C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity

6 September 2017

1 reference

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Neurotoxicity of amyloid β-protein: synaptic and network dysfunction

6 September 2017

1 reference

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The complement system: an unexpected role in synaptic pruning during development and disease

6 September 2017

1 reference

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Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner

6 September 2017

1 reference

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Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature

6 September 2017

1 reference

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Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation

6 September 2017

1 reference

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Aβ oligomers inhibit synapse remodelling necessary for memory consolidation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094372

Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094372

The classical complement cascade mediates CNS synapse elimination

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094372

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

6 September 2017

1 reference

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Alzheimer's disease is a synaptic failure

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094372

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

6 September 2017

1 reference

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Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5094372

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

6 September 2017

1 reference

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Classical MHCI molecules regulate retinogeniculate refinement and limit ocular dominance plasticity

6 September 2017

1 reference

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A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation

26 June 2018

1 reference

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Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity

26 June 2018

1 reference

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An engulfment assay: a protocol to assess interactions between CNS phagocytes and neurons

26 June 2018

1 reference

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Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment.

2 September 2018

1 reference

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Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment

2 September 2018

1 reference

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Synchronized formation and remodeling of postsynaptic densities: long-term visualization of hippocampal neurons expressing postsynaptic density proteins tagged with green fluorescent protein.

2 September 2018

1 reference

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Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

2 September 2018

1 reference

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Structured Illumination Microscopy for the Investigation of Synaptic Structure and Function.

3 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27033548

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.AAD8373

1 reference

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31 March 2020

1 reference

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31 March 2020

PubMed publication ID

27033548

1 reference