Antimicrobial strategies: inhibition of viral polymerases by 3'-hydroxyl nucleosides (Q37396435)

20 August 2017

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title

Antimicrobial strategies: inhibition of viral polymerases by 3'-hydroxyl nucleosides (English)

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20 August 2017

Jerome Deval

1

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20 August 2017

1 January 2009

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20 August 2017

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20 August 2017

69

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20 August 2017

2

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20 August 2017

151-166

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https://scigraph.springernature.com/pub.10.2165/00003495-200969020-00002

20 August 2017

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Use of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus

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Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species

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Fixed conformation nucleoside analogs effectively inhibit excision-proficient HIV-1 reverse transcriptases

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Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine

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Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase

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The relationship between incorporation of E-5-(2-Bromovinyl)-2'-deoxyuridine into herpes simplex virus type 1 DNA with virus infectivity and DNA integrity

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Cidofovir and (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine are highly effective inhibitors of vaccinia virus DNA polymerase when incorporated into the template strand

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Twenty-four-week clevudine therapy showed potent and sustained antiviral activity in HBeAg-positive chronic hepatitis B.

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12 December 2020

Inhibition of Epstein-Barr virus replication by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil

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12 December 2020

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication

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12 December 2020

Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus

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The nucleoside analogs 4'C-methyl thymidine and 4'C-ethyl thymidine block DNA synthesis by wild-type HIV-1 RT and excision proficient NRTI resistant RT variants

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12 December 2020

Lethal mutagenesis of HIV with mutagenic nucleoside analogs

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12 December 2020

Discovery and development of BVDU (brivudin) as a therapeutic for the treatment of herpes zoster

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12 December 2020

The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro

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12 December 2020

10.2165/00003495-200969020-00002

Identifiers

DOI

1 reference

PubMed ID

19228073

Dimensions Publication ID

20 August 2017

0 references

1 reference

PubMed ID

19228073