GRK mythology: G-protein receptor kinases in cardiovascular disease (Q37396870)

20 August 2017

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title

GRK mythology: G-protein receptor kinases in cardiovascular disease (English)

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20 August 2017

cardiovascular disease

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Gerald W Dorn

1

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20 August 2017

20 February 2009

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Journal of Molecular Medicine

20 August 2017

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20 August 2017

87

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20 August 2017

5

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20 August 2017

455-463

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https://scigraph.springernature.com/pub.10.1007/s00109-009-0450-7

20 August 2017

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cites work

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00109-009-0450-7

In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00109-009-0450-7

Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases

21 January 2018

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12 December 2020

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1 reference

12 December 2020

The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs.

1 reference

12 December 2020

Expression of a beta-adrenergic receptor kinase inhibitor reverses dysfunction in failing cardiomyocytes

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12 December 2020

Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling.

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12 December 2020

Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2

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12 December 2020

Beta-adrenergic function in heart muscle disease and heart failure

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12 December 2020

Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction

1 reference

12 December 2020

M opsin phosphorylation in intact mammalian retinas

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12 December 2020

Comparison of the beneficial effect of beta-blockers on mortality in patients with ischaemic or non-ischaemic systolic heart failure: a meta-analysis of randomised controlled trials

1 reference

12 December 2020

Physiological induction of a beta-adrenergic receptor kinase inhibitor transgene preserves ss-adrenergic responsiveness in pressure-overload cardiac hypertrophy

1 reference

12 December 2020

Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses

1 reference

12 December 2020

Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice.

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12 December 2020

G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure

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12 December 2020

Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice

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12 December 2020

Expression of the G protein-coupled receptor kinase 2 during early mouse embryogenesis.

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12 December 2020

Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling

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12 December 2020

Regulation of G protein-coupled receptor kinases by calmodulin and localization of the calmodulin binding domain

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12 December 2020

G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization.

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12 December 2020

Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice

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12 December 2020

Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice

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12 December 2020

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor

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12 December 2020

A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase

1 reference

12 December 2020

Regulation of G protein-coupled receptor kinase subtypes by calcium sensor proteins.

1 reference

12 December 2020

The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group

1 reference

12 December 2020

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

1 reference

12 December 2020

Myocardial adeno-associated virus serotype 6-betaARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure

1 reference

12 December 2020

A predicted amphipathic helix mediates plasma membrane localization of GRK5

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12 December 2020

Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma

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12 December 2020

Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart

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12 December 2020

Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients.

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12 December 2020

What cardiovascular defect does my prenatal mouse mutant have, and why?

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12 December 2020

Effects of two Gbetagamma-binding proteins--N-terminally truncated phosducin and beta-adrenergic receptor kinase C terminus (betaARKct)--in heart failure

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12 December 2020

Regulation of G protein-coupled receptor kinases by caveolin

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12 December 2020

Beta-adrenergic receptor kinase: primary structure delineates a multigene family

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12 December 2020

Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2

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12 December 2020

Purification and characterization of the beta-adrenergic receptor kinase

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12 December 2020

G protein-coupled receptor kinases

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12 December 2020

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor

1 reference

12 December 2020

Beta-adrenergic pathways in nonfailing and failing human ventricular myocardium.

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12 December 2020

EGFR signal transactivation in cancer cells

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12 December 2020

Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor

1 reference

12 December 2020

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

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12 December 2020

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

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12 December 2020

Transduction of receptor signals by beta-arrestins

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12 December 2020

Protein kinases that phosphorylate activated G protein-coupled receptors.

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12 December 2020

G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation.

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12 December 2020

A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure

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12 December 2020

Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function

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12 December 2020

Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation

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12 December 2020

Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level

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12 December 2020

Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin.

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12 December 2020

Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)

1 reference

12 December 2020

Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts

1 reference

12 December 2020

Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq.

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12 December 2020

Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation.

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12 December 2020

Lymphocyte levels of GRK2 (betaARK1) mirror changes in the LVAD-supported failing human heart: lower GRK2 associated with improved beta-adrenergic signaling after mechanical unloading.

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12 December 2020

Gene therapy in heart failure

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12 December 2020

Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling

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12 December 2020

A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling

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12 December 2020

Differential interaction of GRK2 with members of the G alpha q family

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12 December 2020

Localization of the sites for Ca2+-binding proteins on G protein-coupled receptor kinases.

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12 December 2020

Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure

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12 December 2020

Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.

1 reference

12 December 2020

Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy

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12 December 2020

Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure

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12 December 2020

Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

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12 December 2020

Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family

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12 December 2020

G-protein-coupled receptor kinase activity is increased in hypertension

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12 December 2020

10.1007/S00109-009-0450-7

Identifiers

DOI

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20 August 2017

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PubMed ID

19229505